Entry Nos. 14200–14299

2023 CE

#14200

Ultra-fast deep-learned CNS tumour classification during surgery.

Published "open access" 11 October 2023. https://www.nature.com/articles/s41586-023-06615-2 "Abstract: "Central nervous system tumours represent one of the most lethal cancer types, particularly among children1. Prima…

2017 CE

#14201

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.

Prior to their development of the mRNA vaccine for Covid-19, Karikó and Weissman (Nobel Prize 2023) and colleagues used a novel mRNA vaccine, with base modifications created in their laboratory, to generate a p…

1966 CE

#14202

Mendelian inheritance in man; catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes.

Last expanded printed edition: 12th edition, 3 vols., 1998. "Dr Victor A. McKusick wrote an article in 1962 for the Quarterly Review of Biology titled ‘On the X Chromosome of Man’ (1). At that time, X-link…

1934 CE

#14203

The anemias.

1860 CE

#14204

A medico-legal treatise on malpractice and medical evidence, comprising the elements of medical jurisprudence.

The first treatise on malpractice published in the United States and the first book to provide observations on the physician as an expert witness in malpractice cases. Digital facsimile from wellcomecollection.org at …

2004 CE

#14205

Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.

The authors in Korea, led by Woo-suk Hwang, reported the cloning of a human blastocyst using somatic cell nuclear transfer, and deriving pluripotent embryonic stem cells from that cloned blastocyst. In doing so they c…

1979 CE

#14206

Experimental evidence in support of an extra-terrestrial trigger for the Cretaceous-Tertiary extinctions. (Abstract).

Iridium is a very rare element in the Earth's crust, but is found in anomalously high concentrations (around 1000 times greater than normal) in a thin worldwide layer of clay marking the boundary between the Cretaceou…

1980 CE

#14207

Extraterrestrial cause for the Cretaceous-Tertiary extinction.

Following up on No. 14206, the authors stated that the same excess iridium areas were found in two different areas of W. Europe and in New Zealand, and posited that “the anomalous iridium concentrations at the C…

1991 CE

#14208

Chicxulub Crater: A possible Cretaceous/Tertiary boundary impact crater on the Yucatán Peninsula, Mexico.

Eleven years after publication of No. 14207, Alan Hildebrand, working with Luis and Walter Alvarez, proposed that the Chicxulub Crater, discovered by Antonio-Camargo-Zanoguera and Glen T. Penfield during the 1970s, wa…

1931 CE

#14209

U. S. Plant patent 1. Climbing or trailing rose. Filed Aug. 6, 1930. Issued Aug. 18, 1931.

This was the first patent granted for a life form. In response to complaints from the nursery industry that the future of the plant breeding industry was jeopardized by the “pirating” of new plant varietie…

1784 CE

#14210

Die Deutsche [sic] Giftpflanzen, zur Verhütung der tragischen Vorfälle in den Haushaltungen, nach ihren botanischen Kennzeichen, nebst den Heilungsmitteln.

On poisonous plants in Germany, for prevention of tragic household accidents, and remedies for the poisons. Illustrated with 16 plates. Digital facsimile from Google Books at this link.

1883 CE

#14211

De l'Atténuation des virus, avec la collaboration de MM. Chamberland, Roux et Thuillier. Quatrième Congrès international d'hygiène et de démographie. Séance du 5 Septembre 1882.

In his seminal 1880 paper, Sur les maladies virulentes, et en particulier sur la maladie appelée vulgairement choléra des poules, GM-2537, Pasteur developed the idea of a protective inoculation by attenu…

1983 CE

#14212

Evidence for plasmid mediated toxin production in Bacillus anthracis.

The authors illustrated and proved that “heating V770-NPI-R containing anthrax strains, to exactly 42.5 degrees centigrade, as Pasteur and colleagues reported in GM 14211, essentially ‘cured’ these s…

1843 CE

#14213

Ueber die Textur und Function der Medulla oblongata. 2 vols. (Text and atlas).

“In this book, there are many transverse section figures from the origin of the 2nd cervical nerve pair up to the pons. Stilling aimed to reveal the difference between the spinal cord and medulla oblongata by pr…

1859 CE

#14214

Neue Untersuchungen über den Bau des Rückenmarks. 2 vols. (Text and atlas.)

Stilling carried out some of the 19th century’s most detailed and precise examinations of the spinal cord, which “laid the foundation for the modern anatomical study of the spinal cord, medulla oblongata, …

1825 CE

#14215

Elements of operative midwifery.

Davis introduced a number of improvements in instruments and techniques: “It outlines rules and precautions for undertaking operations, described the use of various forms of forceps, and provided twenty detailed…

1970 CE

#14216

Hammond's wall atlas of human anatomy.

With pages measuring 731 x 536 mm., this is the largest anatomical atlas ever published with plastic overlays. The covers include metal grommets so that the book could be hung on the wall. The work was undated, but is…

2003 CE

#14217

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.

The authors showed that mutations in lamin A (LMNA) are the cause of Hutchinson-Gilford progeria sundrom (HGPS). At the end of their abstract they stated that "The discovery of the molecular basis of this disease may …

2021 CE

#14218

In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.

Using the base editor enzyme developed by Liu (GM11865), the authors report that they can “correct the pathogenic HGPS mutation in cultured fibroblasts derived from children with progeria and in a mouse model of…

1996 CE

#14219

Jean Fery: A sixteen century case of dissociative identity disorder.

Abstract: "This discussion reinterprets a sixteenth-century case of possession and exorcism ashttps://archive.org/details/lapossessiondeje00bour/page/n7/mode/2up Dissociative Identity Disorder (DID), formerly known as…

2012 CE

#14220

Medicinal plants of Central Asia: Uzbekistan and Kyrgystan.

"... the first English-language book detailing medicinal plant diversity in the region. More than two hundred of the most important medicinal plants of Central Asia are listed and it includes many whose medicinal uses…

2023 CE

#14221

The Kirtsos historical library of homoeopathic medicine: An annotated bibliographical catalogue.

The definitive bibliographical catalogue of the historical literature of homeopathy.

1976 CE

#14222

Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.

The authors studied 5 diabetic patients and first realized that A1c was an ideal index to reveal the overall control of a patient’s blood sugar over the past several months before a doctor’s visit. They we…

1954 CE

#14223

The structure of haemoglobin - IV. Sign determination by the isomorphous replacement method.

The first demonstration of isomorphous replacement in protein crystallography. This was a key step in determination of the structure of large biological molecules. Harittai, "On the origins of isomorphous replacement …

1981 CE

#14224

The crystallization of ribsomal proteins from the 50 S subunit of the Escherichia coli and Bacillus stearothermophilus ribosome.

The authors crystallized fragments of the 50S subunit of a thermophile bacterium’s ribosome to 3 angstroms resolution. Order of authorship in the original publication: Appelt, Dyck, et al., Yonath. Digital facsi…

1991 CE

#14225

Brass plate and brazen impudence: Dental practice in the provinces 1755-1855.

2003 CE

#14226

Dental practice in Europe at the end of the 18th century. Edited by Christine Hilliam.

1959 CE

#14227

Einführung in die stereotaktischen Operationen mit einem Atlas des menschlichen Gehirns. Introduction to stereotaxis with an atlas of the human brain. Large folio text plus 2 large folio binders of plates with captions.

1863 CE

#14228

The principles and practice of surgery, embracing minor and oeprative surgery; with a bibliographical index of American surgical writers from the year 1783 to 1860. Illustrated by 400 wood-cuts and nearly 1000 engravings on steel. 2 vols.

The most extensively illustrated American manual of surgery issued during the U.S. Civil War.

1936 CE

#14229

The comparative anatomy of the nervous system of vertebrates, including man. 2 vols.

This edition and translation was so extensively reworked and expanded by Kappers, Huber and Crosby that it should be considered a new work. See No. 1247 for the original edition in German. Order of authorship as publi…

1959 CE

#14230

Association of specific overt behavior pattern with blood and cardiovascular findings: Blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease.

Abstract: "Three groups of men, selected solely according to the behavior pattern which they habitually manifested in their work, were compared with respect to their serum cholesterol levels, clotting times, presence …

1971 CE

#14231

Structure of the porcine LH-and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses.

Publication in May 1971: Working with pig preparations, the authors reinvestigated the peptide that they had previously isolated, which acted as an LH-FSH releasing hormone. They performed an Edman-dansyl degradation …

1970 CE

#14232

Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor.

Working with sheep preparations, the authors determined that the molecular structure of TRF (thyroid releasing hormone), is 2-pyrrolidone-5-carboxylyl-histidyl-L-proline amide. On page 324, they showed the molecular s…

1999 CE

#14233

Médecins Sans Frontières. Nobel Lecture.

In 1999 Orbinsky accepted the Nobel Peace Prize for Médecins Sans Frontières “in recognition of the organization's pioneering humanitarian work on several continents." He delivered the organization…

1891 CE

#14234

Anatomie pathologique de la moelle épinière.

1892 CE–1894 CE

#14235

Atlas der pathologischen Histologie des Nervensystems. Herausgegeben von Prof. V. Babes (Bucarest), P. Blocq (Paris, Prof. Ehrlich (Berlin), Prof. Homen (Helsingfors), Prof. P. Marie (Paris, G. Marinesco (Bucarest), Prof. Mendel (Berlin) Prof. Möli (Berlin), Dozen C. v. Monakow (Zürich), Prof. Ramon j Cajal (Barcelon) und Prof. Vanlair (Lüttic). Redigirt von Professor V. Babes und P. Blocq. I. Lieferung: Die krankhaften Veränderungen der Museklnerven und deren Endigungen. II. Lieferung: Régénération des nerves. Degeneration und Entzündung der Nerven.

2003 CE

#14236

Trepanation: History, Discovery, Theory. Edited by Robert Arnott, Stanley Finger, and C.U.M Smith.

1990 CE

#14237

Historical atlas of crystallography.

1931 CE

#14238

Zur Kenntnis des Vitamins-A aus Fischtranen.

In 1930 Karrer established the correct formula for carotene (the chief precursor of vitamin A), the first demonstration of the chemical structure of a vitamin. Shortly thereafter, he was able to determine the formula …

1942 CE

#14239

On the utilization of acetic acid for cholesterol formation.

See also, Rittenberg & Bloch, "The Utilization of Acetic Acid for the Synthesis of Fatty Acids," J. Biol. Chem. 160, 1945, 417-424. Bloch, "The Biological Conversion of Cholesterol to Pregnanediol," J. Biol. Chem. 157…

1960 CE

#14240

β-Hydroxy-β-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.

In 1964 Feodor Lynen shared the Nobel Prize in Physiology or Medicine with Konrad Bloch “for their discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism.” Order o…

1973 CE

#14241

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase activity in human fibroblasts by lipoproteins.

Goldstein and Brown discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develo…

1959 CE

#14242

Receptive fields of single neurones in the cat's striate cortex.

Also: Hubel & Wiesel, Receptive fields, binocular interaction and functional architecture in the cat's visual cortex, J. Physiol., 160, 1962, 106-154. In 1981 Hubel and Wiesel shared half of the Nobel Prize in Physiol…

1954 CE

#14243

In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo.

Discovery of nerve growth factor (NGF). Order of authorship in the original publication: Levi-Montalcini, Meyer, Hamburger. In 1986 Levi-Montalcini was awarded half of the Nobel Prize in Physiology or Medicine, and St…

1965 CE

#14244

The stimulation of epidermal proliferation by a specific protein (EGF).

Discovery of Epidermal Growth Factor (EGF). In 1986 Cohen shared the Nobel Prize in Physiology or Medicine with Rita Levi-Montalcini "for their discoveries of growth factors."

1976 CE

#14245

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

Discovery of V(D)J recombination, the genetic mechanism which produces antibody diversity. In 1987 Tonegawa was awarded the Nobel Prize in Physiology or Medicine "for his discovery of the genetic principle for generat…

1980 CE

#14246

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

In 1978 Furchgott discovered a substance in endothelial cells that relaxes blood vessels, calling it endothelium-derived relaxing factor (EDRF). By 1986, he had worked out EDRF's nature and mechanism of action, and de…

1979 CE

#14247

Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

With CA Gruetter, BK Barry, DB McNamara, DY Gruetter, PJ Kadowitz. In 1998 Ignarro shared the Nobel Prize in Physiology or Medicine with Robert F. Furchgott and Ferid Murad "for their discoveries concerning nitric oxi…

1977 CE

#14248

Nitric oxide activates guanylate cyclase and increases guanosine 3',5'-monophosphate levels in various tissue preparations.

Murad demonstrated that nitroglycerin and related drugs worked by releasing nitric oxide into the body, which relaxed smooth muscle by elevating intracellular cyclic GMP. With W. P. Arnold, C. K. Mittal, S. Katsuki. I…

1975 CE

#14249

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. II. Reconstitution of functional rough microsomes from heterologous components.

"In 1975 Günther Blobel showed that in certain cases amino acids in a protein serve as an address label that determines where a protein is to be delivered. Amino acid sequences determine whether a protein is to b…