Historical Bibliography Updated: June 16, 2026
The structure of haemoglobin - IV. Sign determination by the isomorphous replacement method.
Publication Details
Proc. roy. Soc. Ser. A. Math. & Phys. Sci, 225, 287-307. 1954 CE.
The first demonstration of isomorphous replacement in protein crystallography. This was a key step in determination of the structure of large biological molecules. Harittai, "On the origins of isomorphous replacement in protein crystallography," Structural Chemistry, 33, 2022, 635-639.
Digital facsimile from royalsocietypublishing.org at this link.
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| Catalog Metadata | Reference Information |
|---|---|
| Entry Number | #14223 |
| Permanent Link | https://staging.historyofmedicine.com/entry/16540 |
| Author Bio Link | Wikipedia ↗ |
| External URL | the-structure-of-haemoglobin-iv-sign-determination-by-the-isomorphous-replacement-method |