Entry Nos. 14000–14099
100 Garrison-Morton entries in this range.
1954 CE
#14000
Plaque formation and isolation of pure lines with poliomyelitis viruses.
Dulbecco and Vogt were the first to successfully grow the poliovirus in vitro. They were also able to plaque purify it-- an essential step for subsequent vaccine production.
1955 CE
#14001
Structure of tobacco mosaic virus.
The first discovery of the geometry of a protein structure. Franklin, whose X-ray photographs of DNA were crucial to Watson and Crick's discovery of the molecule's double helix structure in 1953, began researching the…
1696 CE
#14002
G[othofredi]. G[uillelmi]. L[eibnitii]. Relatio ad inclytam Societatem Leopoldinam Naturae Curiosorum, de novo antidysenterico Americano magnis successibus comprobato.
This study of the ipecacuanha root and its effects as a emetic, nauseant, expectorant and dispahoretic, Leibniz issued on what he called "the new American antidysentery drug" after reading about the root in Piso and M…
1926 CE
#14003
Le bactériophage et son comportement.
In this book d'Hérelle reported on the results of quantitative work based on the plaque-count, and dilution methods of assay that he invented. He described a three-step process for the life history of the bacte…
1942 CE
#14004
The identification and characterization of bacteriophages with the electron microscope.
First identification, observation under the electron microscope, and reproduction of photomicrographs of bacteriophages taken through the electron microscope. Digital facsimile, but with poor reproductions of the two …
1943 CE
#14005
Electron microscope studies of bacterial viruses.
This work demonstrated the absorption of the phages on the host cell, and the lysis of the host cell and the liberation of a hundred or so daughter paritcles from each cell. It also showed that the particles multiply …
1975 CE
#14006
Application of synchrotron radiation to protein crystallography: Preliminary results.
First report on the application of synchrotron radiation to protein crystallography. Order of authorship in the original publication: Phillips, Wlodwawer..., Hodgson. Digital facsimile from pnas.org at this link. "Syn…
1979 CE
#14007
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells.
Levine discovered the tumor suppressor protein p53, also known as Tumor protein P53. Because it prevents cancer formation TP 53 is classified as a tumor suppressor gene. The discovery was completed in 1989 and recorde…
1993 CE
#14008
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
Identification by the many scientists in The Huntington's Disease Collaborative Research Group, including Gusella, of the single defective gene on chromosome 4 that causes the progressive brain disorder, Huntington's …
1992 CE
#14009
Unusual resistance to peptidyl transferase to protein extraction procedures.
Noller demonstrated that the ribosome is a ribozyme, a critical step in understanding how ribosomes translate the genetic information in DNA into the language of proteins.
1993 CE
#14010
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.
Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA sil…
2008 CE
#14011
A history of neuro-oncology.
2019 CE
#14012
Sir William Osler's Leonardo da Vinci collection: Flight, anatomy and art.
2012 CE
#14013
A physics-based virtual simulator for cranial microneurosurgery training.
"Abstract "BACKGROUND: "A virtual reality neurosurgery simulator with haptic feedback may help in the training and assessment of technical skills requiring the use of tactile and visual cues. "OBJECTIVE: "To develop a…
2019 CE
#14014
Machine learning identification of surgical and operative factors associated with surgical expertise in virtual reality simulation.
"Abstract "Importance Despite advances in the assessment of technical skills in surgery, a clear understanding of the composites of technical expertise is lacking. Surgical simulation allows for the quantitation of ps…
1994 CE
#14015
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
Discovery of the BRCA1 gene using the technique of restriction fragment length polymorphism (RFLP). (Thanks to Juan Weiss for this reference and its interpretation.)
1994 CE
#14016
Location of a breast cancer susceptibility gene, BRACA2, to chromosome 13q12-13.
Stratton and colleagues discovered the BRCA2 gene. Oder of authorship in the original publication: Wooster, Neuhausen, Mangion....Stratton. (Thanks to Juan Weiss for this reference and its interpretation.)
1834 CE
#14017
Graphic illustrations of abortion and the diseases of menstruation. Consisting of twelve plates from drawings engraved on stone, and coloured by Mr. J. Perry, and two copperplates from the Philosophical transactions, coloured by the same artist. The whole representing forty-five specimens of aborted ova and adventitious productions of the uterus, with preliminary observations, explanations of the figures, and remarks anatomical and physiological.
Concerns miscarriage and aberrant gestation rather than removal or expulsion of embryo or fetus. Digital facsimile from wellcomecollection.org at this link.
1982 CE
#14018
Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells.
Chilton was the first (1977) to demonstrate the presence of a fragment of Agrobacterium Ti plasmid DNA in the nuclear DNA of crown gall tissue. Her research on Agrobacterium also showed that the genes responsible for …
1887 CE
#14019
The topographical anatomy of the child.
The first part of this work concerns cross-sectional anatomy; the second part systematically discusses the differences between anatomy in children and adults of different parts of the body.
1971 CE
#14020
The anatomical basis of medical practice.
A notorious anatomy textbook that was pulled from the market by the publisher due to protest over its use of Playboy magazine type models to illustrate female external anatomy, as well as its sexist language. Preface:…
1986 CE
#14021
The anatomy of the infant head.
2022 CE
#14022
The complete sequence of a human genome.
The first sequence of the complete human genome, telomere to telomere, including transcriptional and epigenetic state of the repeat elements, adding 8% novel genome information left unresolved since the 2001 draft seq…
2021 CE
#14023
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
The authors showed how a coronavirus specific protease inhibitor designed in the lab, that could be administered by mouth to humans, achieved excellent plasma concentrations and antiviral potency. This drug, marketed …
2014 CE
#14024
A brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruits.
Free access from FEBS Press at this link.
1926 CE
#14025
The isolation and crystallization of the enzyme urease.
Sumner first isolated and crystallized an enzyme (urease) and proved that enzymes are proteins. One month after publication of the above paper Sumner reinforced his discovery by recrystalizing urease, publishing a fol…
2021 CE
#14026
Highly accurate protein structure prediction with AlphaFold.
Abstract: "Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1,2,3,4, the structures of around 100,0…
2022 CE
#14027
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.
Abstract: "The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of …
1882 CE
#14028
Experimental physiology: Its benefits to mankind, with an address on unveiling the statue of William Harvey at Folkestone 6th August 1881.
A little-known historical work on the history of physiology and the history of medicine by Owen, who, even though he was trained in medicine, most often wrote on topics in comparative anatomy, zoology, paleontology an…
2005 CE
#14029
Body counts: Medical quantification in historical and sociological perspective / La quantificattion medicale, perspectives historiques et sociologigues. Edited by Gérard Jorland, Annick Opinel and George Weisz.
2021 CE
#14030
History of hospitals in Iran, 550-1950.
2020 CE
#14031
The beginnings of modern medicine in Iran.
2018 CE
#14032
Studies in the history of medicine in Iran.
2004 CE
#14033
Public health in Qajar Iran.
"Until Now, there have been no books and only a few articles available in English that deal with the actual practice of medicine in nineteenth and early twentieth-century Iran. Willem Floor’s Public Health in Qa…
1903 CE
#14034
Le passage du virus rabique à travers les filtres.
By demonstrating that the rabies organism is filterable Remlinger proved that rabies is a virus. The rabies virus was the second virus causing disease in humans to be identified. Remlinger made his discovery by follow…
1965 CE
#14035
The nature of the Negri Body.
The first visual proof, by publication of electron micrographs at 25,000 magnification, that Negri bodies contain enormous numbers of rabies virus particles. Digital facsimile from rupress.org at this link. (Thanks to…
1955 CE
#14036
Old English silver and its medical interest. Presidential Address, Liverpool Medical Institution, 14th October 1954.
Digital facsimile from wellcomecollection.org at this link.
1865 CE
#14037
Persien. Das Land und seine Bewohner. Ethnographische Schilderungen. 2 vols.
In this wide-ranging ethnographic study Polak provided the most authoritative account of his introduction of western medicine into Iran as well as the state of medicine in Iran generally. "Polak (1865, II, pp. 192-348…
1932 CE
#14038
The process of tendon repair: An experimental study of tendon suture and tendon graft.
1883 CE
#14039
Essai de géographie médicale de l'Ille Nosi-Bé près la cote nord-ouest de Madagascar (avec cartes). Thèse pour le doctorat en médicine.
2019 CE
#14040
Deer Leibarzt des Schah Jacob E. Polak 1818-1891. Eine west-östliche Lebensgeschichte.
2006 CE
#14041
Race and the odd history of human paleontology.
Abstract: "Although the late 17th century witnessed the recognition of fossils as the remains of extinct organisms—because they could be incorporated into the creation story embodied in the Great Chain of Being&…
1864 CE
#14042
The reputed fossil man of the Neanderthal.
King believed that the Feldhofer Neanderthal skull discovered by Fuhrott and Schaafhausen differed significantly from all known ancient and modern human crania. In this paper he proposed the name Homo neanderthalensis…
2020 CE
#14043
Patents on life: Religious, moral, and social justice aspects of biotechnology and intellectual property. Edited by Thomas C. Berg, Roman Cholij, and Simon Ravenscroft.
1910 CE
#14044
The orders of mammals. Part 1.- Typical stages in the history of the ordinal classification of mammals. Part II. - Genetic relations of the mammalian orders; with a discussion of the origin of the mammalia and of the problem of the auditory ossicles.
Gregory's PhD dissertation, of particular significance for its exhaustive analysis of prior taxonomic systems for mammalia. Digital facsimile from Google Books at this link.
1862 CE
#14045
On the extent and aims of a national museum of natural history.
Owen was the prime mover behind the construction of the Natural History Museum, a project that occupied him for over two decades. His On the Extent and Aims of a National Museum of Natural History, containing the text…
1996 CE
#14046
The lac Operon: A short history of a genetic paradigm.
1864 CE
#14047
The origin of human races and the antiquity of man deduced from the theory of “natural selection."
Wallace delivered this paper to the polygenist Anthropological Society of London on 1 March 1864. It represents “the first effort to connect natural selection to the touchy problem of the evolution of human race…
2006 CE
#14048
An inconvenient truth. The planetary emergency of global warming and what we can do about it.
A politician, Gore was one of the first to draw popular attention to climate change. He supplemented the best-selling book with a film and DVD with the same title. Ten years later, recognizing that in spite of its wid…
2022 CE
#14049
Climate change increases cross-species viral transmission risk.
1) Using a phylogeographical model of the mammal-virus network, and projections of geographical range shifts, the authors assert that 3,139 mammal species will aggregate in new combinations at high elevations, seeking…