Facets

1873 CE

#12261

Eine periodische Function des isolirten Froschherzen.

"Using an isolated frog heart preparation with ligatures around the atria, Luigi Luciani, an Italian physiologist working in 1873 in Carl Ludwig’s famous laboratory in Leipzig, was the first to demonstrate cardi…

2001 CE

#14273

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Kaelin and colleagues identified aspects of the molecular machinery in Von Hippel-Landau disease that regulates the activity of genes in response to varying levels of oxygen. In 2019 Kaelin shared the Nobel Prize in P…

1971 CE

#13958

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

In 1982 Vane shared the Nobel Prize in Physiology or Medicine with Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances."

1983 CE

#6996

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

Isolation of the human immunodeficiency virus (HIV-1). In 2008 Barré-Sinoussi and Montagnier shared half of the Nobel Prize in Physiology and Medicine "for their discovery of human immunodeficiency virus." The …

1974 CE

#9942

The DNA of CAENORHABDITIS ELEGANS.

Digital facsimile from PubMedCentral at this link.

1999 CE

#14270

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

The focus of both Peter Ratcliffe’s and William Kaelin’s work, for which they shared the Nobel Prize with Gregg Semenza, was the relationship between pVHL and HIF. This led to an increased understanding of…

1994 CE

#14261

Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization.

Order of authorship in the original publication: Baba, M., Takeshige, Baba, N., Ohsumi. In 2016 Oshuni received the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy."

1882 CE–1883 CE

#11737

"A study of the malformations, variations, and anomalies of the circulatory apparatus in man," with a brief consideration of some of the principles governing their production.

A pioneering study of the embryology of the cardiovascular system and its relationship to congenital heart disease.

1966 CE

#14064

"Fertile" intestine nuclei.

Gurdon and Uehlinger replaced the cell nucleus of frog ova with frog intestinal nuclei to generate tadpoles, some of which became fertile adult male and female frogs. In 2012 the Nobel Prize in Physiology or Medicine …

1957 CE

#14250

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as reserpine rntagonists.

Carlsson demonstrated that dopamine was a neurotransmitter in the brain and not just a precursor for norepinephrine. Digital facsimile from nature.com at this link. In 2000 Arvid Carlsson shared the Nobel Prize in Phy…

1948 CE–1966 CE

#12191

A bibliographical sourcebook of compressed air, diving and submarine medicine. 3 vols.

Vol. 1 by Hoff; Vols. 2 and 3 by Hoff and Greenbaum, Jr. Digital facsimiles of all three volumes from U.S. National Library of Medicine at this link.

1961 CE

#11201

A bibliography of the Honourable Robert Boyle, Fellow of the Royal Society. Second edition

1989 CE

#11198

A bibliography of the writings of Dr. William Harvey 1578-1657. Third edition, revised by Gweneth Whitteridge and Christine English.

This is the definitive edition of a bibliography first published by Sir Geoffrey Keynes in 1928 on the three hundredth anniversary of De motu cordis, and revised by him for a second edition in 1953. It contains a new …

1935 CE

#11516

A bibliography of two Oxford physiologists: Richard Lower 1631-1691, John Mayow 1643-1679

1982 CE

#1588.18

A bio-bibliography for the history of the biochemical sciences since 1800.

An index to bio-bibliographical articles listed alphabetically by scientist. Supplement published, Philadelphia, 1985.

1876 CE

#2707

A case of haemophilia complicated with multiple naevi.

First description of multiple hereditary telangiectasis (“Rendu–Osler–Weber disease”).

1991 CE

#10767

A conceptual history of modern embryology. Edited by Scott F. Gilbert. Developmental biology: A comprehensive synthesis, vol. 7.

1897 CE

#1573

A contribution to the history of the respiration of man.

1831 CE

#768.1

A critical and experimental essay on the circulation of the blood.

Marshall Hall clearly distinguished arterioles and venules from capillaries, and he described arteriovenous shunts.

2017 CE

#12626

A cultural history of medical vitalism in Enlightenment Montpellier.

"One of the key themes of the Enlightenment was the search for universal laws and truths that would help illuminate the workings of the universe. It is in such attitudes that we trace the origins of modern science and…

1662 CE

#666

A defence of the doctrine touching the spring and weight of the air.

Boyle’s law. The above pamphlet was appended to the second edition of Boyle’s The spring and weight of the air, 1662. The relevant passage is reproduced inj. F. Fulton’s Selected readings in the hist…

1968 CE

#10044

A definition of irreversible coma. Report of the Ad Hoc Committee of the Harvard Medical School to examine the definition of brain death.

This report described the following characteristics of a permanently nonfunctioning brain, a condition it referred to as "irreversible coma," now known as brain death: 1. Unreceptivity and unresponsitivity--patient sh…

1887 CE

#833

A demonstration on man of electromotive changes accompanying the heart’s beat.

Waller was first to use electrodes and leads in demonstrating the action currents of the heart, avoiding the necessity of opening the chest of laboratory animals and preparing the way for present-day clinical electroc…

1928 CE

#856.1

A double perfusion-pump.

Mechanical heart.

1978 CE

#7456

A gene complex controlling segmentation in Drosophila.

Discovery of the Drosophila Bithorax complex and elucidation of its function. Lewis founded the field of developmental genetics and laid the groundwork for current understanding of the universal, evolutionarily conser…

1972 CE

#1588.10

A history of biochemistry. 5 vols.

Forms vols. 30-34 of Comprehensive biochemistry, edited by M. Florkin and E. H. Stotz.

1934 CE

#533

A history of embryology.

An exhaustive history of the subject. Deals with embryology from the earliest times to the beginning of the 19th century and includes a valuable bibliography and many illustrations. Second edition, with the assistance…

1986 CE

#534.42

A history of embryology. British Society for Developmental Biology Symposia 8. Edited by T. J. Horder, J. A. Wikowski and C. C. Wylie.

A survey of the history of developmental biology from 1880.

1992 CE

#10671

A history of gastric secretion and digestion: Experimental studies to 1975.

1983 CE–1988 CE

#1588.19

A history of neurophysiology in the 17th and 18th centuries. From concept to experiment. A history of neurophysiology in the 19th century. 2 vols.

2013 CE

#13230

A history of psycholinguistics: The Pre-Chomsky Era.

2001 CE–2011 CE

#13227

A History of Speech - Language Pathology.

https://www.acsu.buffalo.edu/~duchan/new_history/overview.html "Organization of the website "The website is divided into six historical periods: History of the ancients: 3000 BC to 500 AD Middle ages: 400 to 1500 AD E…

1968 CE

#5019.7

A history of the treatment of speech disorders.

1810 CE

#4969.2

A letter to Henry Cline, Esq. on imperfect developements (sic) of the faculties mental and moral, as well as constitutional and organic; and on on the treatment of impediments of speech.

The first book on mental deficiency. Thelwall recognized that sensory deprivation could be a cause of apparent mental defect through his work with handicapped children. He established criteria for distinguishing betwe…

2006 CE

#8656

A most amazing scene of wonders: Electricity and enlightenment in early America.

"By examining the lives and visions of natural philosophers, spectacular showmen, religious preachers and medical therapists, he shows how electrical experiences of wonder, terror, and awe were connected to a broad ar…

1964 CE

#1931.5

A new adrenergic beta-receptor antagonist.

Development of Propranolol, the first beta-blocker effectively used in the treatment of coronary heart disease and hypertension. R. G. Shanks, L. H. Smith and A. C. Dornhorst. In 1988 the Nobel Prize in Physiology or …

1844 CE

#11646

A new view of insanity: The duality of the mind proved by the structure, functions and diseases of the brain and by the phenomena of mental derangement and shown to be essential to moral responsibility. With an appendix: 1. On the influence of religion on insanity. 2. Conjectures on the nature of the mental operations. 3. On the management of lunatic asylums.

"From the seventeenth century there were shifts in some of the basic assumptions about how the brain and mind functioned, and there are some useful markers along the way to an era of more systematic studies. Descartes…

1991 CE

#13930

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition.

"In their landmark paper published in 1991, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein coupled receptors. By analyzing rat DNA, they estimated that there were approxi…

1999 CE

#14262

A pdf Neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila.

In 2017 Hall shared the Nobel Prize in Physiology or Medicine with Michael Rosbash and Michael W. Young “for their discoveries of molecular mechanisms controlling the circadian rhythm.” Order of authorship…

1939 CE

#14053

A preliminary atlas of early human fetal activity.

The first published photographic study of fetal physiology using live human fetuses. Includes 20 full-age photographic plates, each with 6-12 images (189 total). The fetuses, all between 8.5 and 14 weeks gestation, we…

1889 CE

#1419

A record of experiments upon the functions of the cerebral cortex.

A detailed analysis, by means of faradic stimulation, of the motor responses of the cerebral cortex, internal capsule, and spinal cord of higher primates.

1970 CE

#6889

A restriction endonuclease from Hemophilus influenzae. II. Base sequence of the recognition site.

Discovery of the first type II restriction enzyme (HindII). Smith shared the 1978 Nobel Prize in Physiology or Medicine with Werner Arber and Daniel Nathans "for the discovery of restriction enzymes and their applicat…

1949 CE

#1583

A short history of physiology. 2nd ed.

1897 CE

#2807

A simple and accurate form of sphygmomanometer or arterial pressure gauge contrived for clinical use.

Hill and Barnard made an important modification to the Riva-Rocci sphygmomanometer when they substituted a pressure gauge in place of the mercury manometer used for pressure readings.

1955 CE

#13685

A small particulate component of the cytoplasm.

Palade first described the association of what were subsequently determined to ribosomes with membranes. He and Keith Porter subsequently named this structure the endoplasmic reticulum. Digital facsimile from PubMedCe…

1946 CE

#1354.1

A specific sympathomimetic ergone in adrenergic nerve fibres (sympathin) and its relations to adrenaline and nor-adrenaline.

Noradrenaline shown to be the predominant transmitter of the effects of sympathetic nerve impulses. In 1970 Euler shared the Nobel Prize in Physiology or Medicine with Katz and Axelrod "for their discoveries concernin…

1932 CE

#2717

A standard stimulus for measuring vasomotor reactions: its application in the study of hypertension.

Cold-pressor test.

1947 CE

#10692

A study of nerve physiology. 2 vols.

See, Jorge A. Larriva-Sahd, "Some predictions of Rafael Lorente de Nó 80 years later," Frontiers in neuoranatomy, 8 (2014) 147.

1948 CE

#1929.4

A study of the adrenotropic receptors.

Described the concept of α and β adrenergic receptors in the sympathetic nervous system, and placed specific receptors into pharmacologic mechanisms.

1927 CE

#12226

A study of the electrical field surrounding active heart muscle.

At Johns Hopkins Hospital Craib evolved his fundamental theory of the doublet hypothesis which revolutionized electrocardiographic thinking. Until then, it was held that electricity in the heart differed from electric…