Entry Nos. 1000–1099

1913 CE

#1050

The relation of growth to the chemical constituents of the diet.

Like McCollum and Davis, Osborne and Mendel showed the necessity in diet of a factor which was later to be known as vitamin A.

1914 CE

#1051

Die Vitamine

A pioneer work in the study of vitamins. Much of the previous literature is reviewed. Funk introduced the term “vitamine”, later changed to “vitamin”. In 1912 (J. State Med., 20, 341) he postul…

1918 CE

#1052

The newer knowledge of nutrition.

1919 CE

#1053

Note on the role of the antiscorbutic factor in nutrition.

In 1920 Drummond suggested the term “vitamin”.

1921 CE

#1054

Fat-soluble vitamine. VII. The fat-soluble vitamine and yellow pigmentation in animal fats with some observations on its stability to saponification.

Separation of vitamin A from vitamin D. With M. Sell and M. Van R. Buell.

1922 CE

#1055

On the existence of a hitherto unrecognized dietary factor essential for reproduction.

Discovery of vitamin E. See also their later paper in J. Amer. med. Ass.,1923, 81, 889-92.

1925 CE

#1056

Fat-soluble vitamin. XXVI. Antirachitic property of milk and its increase by direct irradiation and by irradiation of the animal.

Demonstration that the therapeutic properties of ultra-violet light could be effectively stored in foods and later released after consumption. With E. B. Hart, C. A. Hoppert, and A. Black.

1926 CE

#1057

A further study of butter, fresh beef, and yeast as pellagra preventives, with consideration of the relation of factor P-P of pellagra (and black tongue of dogs) to vitamin B.

Anti-pellagra vitamin (B2, riboflavine). With G. A. Wheeler, R. D. Lillie, and L. M. Rogers.

1926 CE

#1058

Antineuritische Vitamine.

Isolation of vitamin B1 (aneurine, thiamine), lack of which is a cause of beri-beri.

1928 CE

#1059

Observations on the function of peroxidase systems and the chemistry of the adrenal cortex. Description of a new carbohydrate derivative.

Isolation of vitamin C, ascorbic acid. In 1937 Szent-Györgyi was awarded the Nobel Prize in Physiology or Medicine "for his discoveries in connexion with the biological combustion process with special reference t…

1928 CE

#1060

The tripartite nature of vitamin B.

Vitamin B3.

1929 CE

#1061

The absorption spectrum of vitamin D.

See No. 1065. With C. Fischmann, R. G. C. Jenkins, and T. A. Webster.

1929 CE

#1062

Cholesterinstoffwechsel in Hühnereiern und Hühnchen.

In 1943 Dam shared the Nobel Prize with Doisy "for discovery of vitamin K, the blood coagulating factor."

1930 CE

#1063

On the nature and rôle of the fatty acids essential in nutrition.

Demonstration of the need of the body for certain unsaturated fatty acids (vitamin F).

1930 CE

#1064

Maintenance nutrition in the adult pigeon and its relation to torulin (vitamin B1).

Discovery of vitamin B5, probably identical with nicotinic acid. With H. W. Kinnersley and R. A. Peters.

1931 CE

#1065

The quantitative estimation of vitamin D by radiography.

Medical Research Council Special Report No. 158. R. B. Bourdillon, H. M. Bruce, C. Fischmann, R. G. C. Jenkins, and T. A. Webster isolated from irradiated ergosterol a crystalline compound, calciferol, which, weight f…

1931 CE

#1066

The vitamins.

1932 CE

#1067

Crystalline vitamin D.

Written with R. B. Bourdillon, H. M. Bruce, R. K. Callow, J. St. L. Philpot, and T. A. Webster.

1933 CE

#1068

Synthese der d- und l-Ascorbinsäure (C-Vitamin).

T. Reichstein, A. Grüssner, and R. Oppenauer synthesized vitamin C.

1934 CE

#1069

The lyochromes: a new group of animal pigments.

Chemical formula of riboflavine (vitamin B2).

1934 CE

#1070

Vital need of the body for certain unsaturated fatty acids.

Isolation of vitamin F (linolenic acid).

1936 CE

#1071

The isolation from wheat-germ oil of an alcohol, α-tocopherol, having the properties of vitamin E.

Isolation of vitamin E, named by Herbert M. Evans.

1936 CE

#1072

Vitamin P: Flavonols as vitamins.

Discovery of vitamin P (“citrin”).

1936 CE

#1073

Synthesis of vitamin B1.

Synthesis of aneurine.

1937 CE

#1074

A crystalline vitamin A concentration.

1937 CE

#1075

Studies on vitamin E. The isolation of β-tocopherol from wheat germ oil.

With F. Bergel and T. S. Work.

1937 CE

#1076

Further studies on the concentration of the antipellagra factor.

Chicken pellagra factor.

1938 CE

#1077

The isolation and identification of the anti-black tongue factor.

Isolation of nicotinic acid, the pellagra-preventing factor (Vitamin B3). With R. J. Madden, F. N. Strong, and D. W. Woolley.

1938 CE

#1078

Vitamins and vitamin deficiencies. Vol. 1.

1938 CE

#1079

α-Tocopherol.

P. Karrer, H. Fritzsche, B. H. Ringier, and H. Salomon synthesized vitamin E (α-tocopherol).

1939 CE

#1080

Isolierung des Vitamins K in hochgereinigter Form.

Isolation of vitamin K1 from alfalfa. It was isolated independently by R. W. McKee and his co-workers, J. Amer. chem. Soc., 1939, 61, 1295.

1939 CE

#1081

The isolation of vitamin K1.

Order of authorship in the original publication: Binkley, MacCorquodale, Thayer, Doisy. In 1943 Doisy received half of the Nobel Prize in Physiology or Medicine "for his discovery of the chemical nature of vitamin K."…

1940 CE

#1082

The constitution of vitamin K2.

Structural formula of vitamin K2.

1939 CE

#1083

Synthesis of vitamin K1.

1941 CE

#1084

p-Aminobenzoic acid, a vitamin.

Recognition of β-amenobenzoic acid as a member of the vitamin-B complex.

1940 CE

#1085

A further note on the identity of vitamin H with biotin.

Isolation of β-biotin (formerly known as vitamin H). With D. B. Melville, P. György, and C. S. Rose.

1940 CE

#1086

Anemia in chicks caused by a vitamin deficiency.

Isolation of vitamin Bc (folic acid, pteroylglutamic acid). Preliminary communication in J. biol. Chem., 1939, 128, xlvi-xlvii.

1942 CE

#1087

The isolation of a new oxidation-reduction enzyme from lemon peel (vitamin P).

Isolation of vitamin P (hespendin chalcone).

1943 CE

#1088

Synthetic biotin.

Synthesis of biotin. With D. E. Wolf, R. Mozingo, and K. Folkers.

1943 CE

#1089

Zur Kenntnis des β-Biotins. 34. Mitteilung über pflanzliche Wachstumstoffe.

Isolation of α-biotin.

1947 CE

#1090

Unidentified growth factors for Lactobacillus lactis in refined liver extract.

Mary Shorb provided a method of biological assay of liver extracts that made possible the isolation of vitamin B12.

1948 CE

#1091

Crystalline vitamin B12.

With N. G. Brink, F. R. Koniuszy, T. R. Wood, and K. Folkers.

1948 CE

#1092

Presence of cobalt in the anti-pernicious anaemia factor.

Independently of Rickes et al., Lester Smith isolated vitamin B12 in Britain. See also Nature (Lond.), 1948, 161, 638.

1563 CE–1564 CE

#1093

Opuscula anatomica.

Eustachius is credited with several anatomical discoveries, among them the tensor tympani muscle and the Eustachian tube, published in his chapter entitled De auditus organis. In the last respect, however, he was anti…

1627 CE

#1094

De lactibus sive lacteis venis.

Records the discovery of the lacteal vessels. While performing vivisection on a dog that had recently fed, Aselli noticed a network of vessels in the mesentery and along the peritoneal surface of the intestine. The ve…

1651 CE

#1095

Experimenta nova anatomica, quibus incognitum chyli receptaculum, et ab eo per thoracem in ramos usque subclavis vasa lactea deteguntur.

Pecquet discovered the thoracic duct in dogs and its relation to the lacteals. Using a dog that was digesting, he described the thoracic duct, its entry into the subclavian veins, and the receptaculum chyli or chyle r…

1652 CE

#1096

De lacteis thoracicis in homine brutisque.

Contains Bartholin’s discovery of the thoracic duct. English translation, 1653.

1653 CE

#1097

Vasa lymphatica.

Bartholin disputed the claim of Rudbeck as to priority in the discovery of the intestinal lymphatics. Although anticipated in this by Rudbeck, there is no doubt that Bartholinus was the first to appreciate the signifi…

1653 CE

#1098

Nova exercitatio anatomica, exhibens ductus hepaticos aquosos, et vasa glandularum serosa.

Rudbeck claimed to have discovered the intestinal lymphatics and their connexion with the thoracic duct in 1651, a claim disputed as to priority by Bartholin (Nos. 1096-97). This book was reproduced in facsimile in 19…

1665 CE

#1099

Dilucidatio valvularum in vasis lymphaticis et lacteis.

First description of the valves of the lymphatics, discovered by Ruysch. Facsimile reprint, Niewkoop, De Graaf, 1964.