Entry Nos. 3800–3899

1915 CE

#3848

Experimental hyperthyroidism.

First successful experimental production of exophthalmic goitre. With C. A. L. Binger and R. Fitz.

1918 CE

#3849

Das Myxödemherz

First systematic study of the characteristic changes of the heart in myxedema.

1919 CE–1920 CE

#3850

Epinephrin hypersensitiveness test in the diagnosis of hyperthyroidism.

Goetsch devised a skin reaction test for use in the diagnosis of hyperthyroidism

1924 CE

#3851

The value of iodine in exophthalmic goitre.

Plummer and Boothby recommended the pre-operative administration of iodine in exophthalmic goitre.

1932 CE

#3852

Diseases of the thyroid gland, with special reference to thyrotoxicosis.

Second edition, 1951. Joll was a pioneer in the treatment of thyrotoxicosis by means of subtotal thyroidectomy.

1942 CE

#3853

Application of radioactive iodine in therapy of Graves’s disease.

1943 CE

#3854

Treatment of hyperthyroidism with thiourea and thiouracil.

Astwood was the first to treat human cases of hyperthyroidism with thiourea and thiouracil.

1945 CE

#3855

Some observations on the use of thiobarbital as an antithyroid agent in the treatment of Graves’s disease.

Clinical introduction of thiobarbital.

1892 CE

#3856

Lieber erfolgreiche Einheilung der Katzenschilddrüse in die Bauchdecke und Auftreten von Tetanie nach deren Exstirpation.

Experimental production of tetany by excision of the thyroid of a cat, previously successfully transplanted into the abdomen.

1896 CE

#3857

Sugli effeti dell’ estirpazione delle ghiandole paratiroidee.

Demonstration that tetany follows removal of the parathyroids. A French translation of the paper is in Arch. ital. Biol., 1896, 25, 459-64.

1904 CE

#3858

Ueber Ostitis deformans ohne osteoides Gewebe.

Askanazy was the first to associate osteitis fibrosa cystica with parathyroid tumors.

1909 CE

#3859

On the relation of tetany to the parathyroid glands and to calcium metabolism.

Proof that the parathyroids control calcium metabolism. MacCallum and Voegtlin were able to demonstrate the removal of post-parathyroidectomy tetany by administration of calcium.

1909 CE

#3860

Auto- and isotransplantation, in dogs, of the parathyroid glandules.

1925 CE

#3862

A case of tetany treated with parathyrin.

First use of parathyroid hormone in the treatment of tetany.

1925 CE

#3863

Therapeutischer Versuch bei Ostitis fibrosa generalisata mittels Exstirpation eines Epithelkörperchentumors.

Mandl was the first successfully to treat generalized osteitis fibrosa by extirpation of a parathyroid tumor.

1855 CE

#3864

On the constitutional and local effects of disease of the supra-renal capsules.

Addison was the first to draw attention to the importance of the adrenals in clinical medicine. The above work first appeared in the Lond. med. Gaz., 1849, 43, 517-18, and was later expanded into book form. It describ…

1886 CE

#3865

Ein Fall von doppelseitigem, völlig latent verlaufenen Nebennieren-tumor und gleichzeitiger Nephritis mit Veränderungen am Circulationsapparat und Retinitis.

Pheochromocytoma first described. Republished in book form.

1901 CE

#3866

A study of congenital sarcoma of the liver and suprarenal. With report of a case.

Pepper’s type of adrenal medullary tumor.

1905 CE

#3867

On the relation of the suprarenal capsules to the sex organs.

First recognition of the “adrenogenital syndrome”. This paper showed a relationship to exist between the adrenals and the sex organs.

1907 CE

#3868

On suprarenal sarcoma in children with metastases in the skull.

Hutchison’s tumors.

1945 CE

#3869

A tentative test for pheochromocytoma.

The Roth–Kvale histamine test for the diagnosis of pheochromocytoma.

1921 CE

#3870

La virilisme pilaire et son association à l’insuffisance glycolytique (Diabète des femmes à barbe).

“Achard–Thiers syndrome”. These writers established as a definite syndrome the combination of hirsutism with diabetes.

1922 CE

#3871

Crises solaires et hypertension paroxystique en rapport avec une tumeur surrénale.

First full description of chromaffin cell tumors of the adrenal medulla. With J. Tinel and E. Doumer.

1925 CE

#3872

A case of virilism associated with a suprarenal tumour: recovery after its removal.

Records the first removal (by P. Sargent) of an adrenal cortical tumor. This was followed by disappearance of the heterosexual symptoms, thus establishing the relationship of sexual abnormality and adrenal tumors.

1929 CE

#3873

Suprarenal cortical extracts in suprarenal insufficiency (Addison’s disease).

Rogoff and Stewart were the first to use adrenal cortical extract (“inter-renalin”) in the treatment of adrenal insufficiency. See also No. 1148.

1932 CE

#3874

The adrenal cortical hormone.

The cortical hormone prepared by Swingle and Pfiffner (“eschatin”) was found to be very effective in the treatment of Addison’s disease. Their first paper on the subject appeared in Science, 1930, 71…

1933 CE

#3875

The adrenal cortex; a surgical and pathological study.

Includes the demonstration, by Vines, of virilism with the aid of a new stain; cortical cells of the adrenals removed at operation stained an abnormal (red) color – the so-called Ponceau fuchsin stain.

1937 CE

#3876

Genital abnormalities, hermaphroditism and related adrenal diseases.

1939 CE

#3877

Treatment of adrenal insufficiency by means of subcutaneous implants of pellets of desoxycorticosterone acetate (a synthetic adrenal cortical hormone).

With L. L. Engel and H. Eisenberg. For treatment of Addison’s disease by the same method, see the same journal, pp. 339-65.

1758 CE–1763 CE

#3878

De cranii ustione in pertinacioribus capitis vitiis. In his: Ratio medendi in nosocomio practico, 6, 239-287. 8 vols.

Haen provided the first description of amenorrhea in connection with a pituitary tumor. He recorded the case history of a young woman suffering from amenorrhea as well as many neurological symptoms assumed to result f…

1794 CE

#3879

De curandis hominum morbis epitome. Liber V.

Frank was the first to define diabetes insipidus (pp. 38-67).

1801 CE

#3880

Accroissement singulier en grosseur des os d’un homme âgé de 39 ans. In: Mélanges de chirurgie, 407-11.

Saucerotte described before the Académie de Chirurgie in 1772 a case of what is now known to have been acromegaly. This is the first known clinical description of the disease, and is one of the five cases inclu…

1823 CE

#3881

Observations sur les maladies de l’appendice sus-sphenoïdal (glande pituitaire) du cerveau.

Includes description of pituitary obesity.

1840 CE

#3882

Hypertrophie der Hypophysis cerebri und dadurch bedingter Druck auf die Hirngrundfläche, insbesondere auf die Sehnerven, das Chiasma derselben und den linkseitigen Hirnschenkel.

The first case of pituitary obesity with infantilism (Fröhlich’s syndrome) was reported by Mohr. Coincidentally, this appears in the same volume of the Wochenschrift as does Basedow’s classic descript…

1871 CE

#3883

Du féminisme et de l’infantilisme chez les tuberculeux.

In a letter prefaced to Faneau de La Cour’s thesis, Paul Joseph Lorain (1827-1875) described the idiopathic arrest of growth now known as “Lorain’s type”. It was subsequently ascribed to hypopi…

1886 CE

#3884

Sur deux cas d’acromégalie. Hypertrophie singulière non congénitale des extrémités supérieures, inférieures et céphalique.

In this, the first complete clinical description of the condition, Marie suggested the name “acromegaly”. The paper excited much interest and was translated into English and published by the New Sydenham S…

1887 CE

#3885

Lieber einen Fall von Akromegalie.

Minkowski called attention to the constancy of pituitary enlargement on acromegaly; he was the first definitely to note this relationship.

1893 CE

#3886

Notes on a case of acromegaly treated by operation.

First attempt (unsuccessful) to treat acromegaly operatively. Decompression was performed to relieve cranial pressure.

1900 CE

#3887

Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux.

Babinski preceded Fröhlich in describing dystrophia adiposo-genitalis.

1900 CE

#3888

Beiträge zur normalen und pathologischen Histologie der menschlichen Hypophysis cerebri.

Benda showed that the pituitary tumor in acromegaly consists of chromophil cells.

1901 CE

#3889

Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie.

Fröhlich’s classic description of dystrophia adiposogenitalis, pituitary tumor, with obesity and sexual infantilism (“Fröhlich’s syndrome”). Reprinted (in German) in Research Publicat…

1906 CE

#3890

Sexual infantilism with optic atrophy in cases of tumor affecting the hypophysis cerebri.

1906 CE

#3891

Zur Frage der Operationen an der Hypophyse.

Schloffer’s Operation for acromegaly. He was the first successfully to operate upon a pituitary tumor in man (See No. 3892).

1907 CE

#3892

Erfolgreiche Operation eines hypophysen Tumors auf nasalem Wege.

Schloffer’s Operation by the nasal route.

1908 CE

#3893

Insuffisance thyro-ovarienne et hyperactivité hypophysaire (troubles acromégaliques).

Rénon–Delille syndrome – dyspituitarism manifested by lowered blood-pressure, tachycardia, oliguria, insomnia, hyperhidrosis, and intolerance to heat.

1909 CE

#3895

Eine neue Methode der endonasalen operation von Hypophysentumoren.

Hirsch first demonstrated the transnasal transseptal exposure of the sphenoid sinus and pituitary gland in a cadaveric specimen in front of the medical society of Vienna.

1912 CE

#3896

The pituitary body and its disorders.

The first clinical monograph on the hypophysis. Cushing, outstanding neurological surgeon of the early 20th century, added much to our knowledge of the pituitary body and its disorders. The above work includes a descr…

1912 CE

#3897

Ueber Beziehungen der Hypophyse zum Diabetes insipidus.

Frank was the first definitely to connect the posterior lobe of the pituitary with diabetes insipidus.

1912 CE

#3898

Acromegaly: a personal experience.

Mark, a medical practitioner, suffered from acromegaly from the age of 24. The condition was obvious to his friends, but Mark was 50 before he realized the cause of the symptoms of which he had kept a record for many …

1913 CE

#3899

Infantilism hypophysaire.

Classic account of pituitary infantilism.