Entry Nos. 3000–3099

1556 CE

#3049

Curationum medicinalium centuriae quatuor.

Contains (Cent. iii, curat. 70, p. 286) first recorded case of purpura as a separate entity, not associated with fever. English translation of this section in Major, Classic descriptions of disease, 3rd. ed., 1945, p.…

1652 CE

#3050

Iatrologismorum seu medicinalium observationum pentecostae quinque utilibus praeceptis.

Panaroli described hemolytic jaundice of the newborn.

1735 CE

#3051

Epistolica dissertatio altera pro spicilegio observationum de morbo maculoso haemorrhagico et noxiis nonnulis mytulis perscripta.

Behrens gave the name “morbus maculosus haemorrhagicus” to the disease purpura haemorrhagica. His paper is reprinted in Werlhof’s Opera medica, Hannover, 1775, 2,615-36.

1735 CE

#3052

Disquisitio medica et philologica de variolis et anthracibus.

Werlhof gave a classic description of purpura haemorrhagica (“Werlhof’s disease”).

1803 CE

#3054

An account of an haemorrhagic disposition existing in certain families.

Otto recognized and adequately described hemophilia, noting that females are not affected but may transmit the disease. His paper is one of the first great contributions to medicine in North America. Reproduced in Maj…

1811 CE

#3055

Observations on the surgical anatomy of the head and neck.

Burns was the first to suggest (p. 31) ligature of the innominate artery. His book describes “Burns’s space”, the fascial space at the suprasternal notch. The first recorded case of chloroma (myeloid…

1820 CE

#3056

Von einer erblichen Neigung zu tödtlichen Blutungen.

In his description of hemophilia Nasse stressed the immunity of females, despite their ability to transmit the disease. This fact has become known as “Nasse’s law”.

1823 CE

#3057

Observations sur l’état des veines dans les infiltrations des membres.

Description of venous obstruction and edema.

1837 CE

#3058

Peliosis rheumatica. In his Allgemeine und specielle Pathologie und Therapie, 2, 48-49.

“Schönlein’s disease” (purpura) first described. English translation in No. 2241.

1843 CE

#3059

Experimental and practical researches on inflammation and on the origin and nature of tubercles of the lungs.

Addison made important observations on the blood corpuscles. He is by some considered “the world’s first hematologist”. He gave the first description of leucocytosis, so named by Virchow in 1858, and…

1843 CE

#3060

Essai d’hématologie pathologique.

The first monograph on hematology in its "modern" sense. Andral established analysis of the blood on the basis of exact knowledge of the blood components. He analysed the blood fibrin and albumin. He recognized severa…

1845 CE

#3061

Case of hypertrophy of the spleen and liver, in which death took place from suppuration of the blood.

First definite description of leukemia as a blood disorder; a case under the care of Sir R. Christison but reported by Bennett. On p. 400 of the same journal is a report of a case by D. Craigie, referring to a patient…

1845 CE

#3062

Weisses Blut.

Only six weeks after Bennett, Virchow independently published a report on the necropsy of a case of leukemia. He gave the condition its present name. For translation, see Major, Classic descriptions of disease, 3rd. e…

1855 CE

#3063

Die Haemophilie oder die Bluterkrankheit.

First full clinical description of hemophilia.

1856 CE

#3064

Ueber farblose Blutkörperchen und Leukämie. In his Gesammelte Abhandlungen zur wissenschaftlichen Medicin, pp. 147-218.

Includes his paper on “weisses Blut” (see No. 3062) and three later papers on leukemia. See No. 3006.

1868 CE

#3065

Über den Zusammenhang von Purpura und Intestinalstörungen.

“Henoch’s purpura”. Henoch described a form of purpura with abdominal symptoms first mentioned by Heberden (No. 3053). See also the same journal, 1874, 11,622, 641-43. This paper is translated into E…

1870 CE

#3066

Ein Fall von Leukämie mit Erkrankung des Knochenmarkes.

Neumann was the first to note changes in the bone marrow in leukemia, and he proposed the term “myelogenous leukemia”.

1875 CE

#3067

Ueber das Vorkommen von Bilirubinkrystallen bei neugebornen Kindern.

Kernicterus first described.

1887 CE

#3068

Ueber Purpura fulminans.

First description.

1890 CE

#3069

Die Gelenkerkrankungen bei Blutern mit Berücksichtigung der Diagnose.

König gave a detailed description of joint involvement in hemophilia.

1892 CE

#3070

Sur une forme spéciale de cyanose s’accompagnant d’hyperglobulie excessive et persistante.

Vaquez first described polycythemia vera (erythremia). Osler’s paper on the subject (No. 3073) made it generally known in the English-speaking world, and the condition has since been named “Vaquez–Os…

1899 CE

#3071

A new preparation for rapidly fixing and staining blood.

Jenner’s methylene blue-eosin stain for blood.

1901 CE

#3072

A fatal case of acute primary infectious pharyngitis.

First recorded case of extreme leucopenia.

1903 CE

#3073

Chronic cyanosis, with polycythaemia and enlarged spleen: a new clinical entity.

When describing polycythemia with cyanosis, Osler thought it a new entity, but later acknowledged the priority of Vaquez’s description (No. 3070). Reprinted in Med. Classics, 1939, 4,254-75.

1903 CE

#3074

Ueber eine Methode zur Untersuchung des lebenden Knochenmarks von Thieren und über das Bewegungsvermögen der Myelocyten.

Wolff-Eisner trephined the tibia and femur of experimental animals and suggested biopsy of bone marrow as a clinical procedure.

1904 CE

#3075

Die neutrophilen weissen Blutkörperchen bei Infektions-Krankheiten.

“Arneth count”. Arneth distinguished five groups of polymorphonuclear leucocytes and advocated the estimation of these groups as a valuable aid in the determination of bone-marrow reaction to infective and…

1905 CE

#3076

Die Bedeutung der Blutdruckmessung für die Praxis.

Includes (p. 396) description of “Geisböck’s disease” – polycythemia hypertonica.

1905 CE

#3077

Pathologie der Primärerkrankungen des lymphatischen und hämatopoetischen Apparates.

Includes (p. 151) Sternberg’s description of lymphogranulomatosis, which was given the eponym “Sternberg’s disease”.

1907 CE–1908 CE

#3078

Blutkrankheiten und Blutdiagnostik.

1907 CE

#3079

Septische Erkrankungen bei Verkümmerung des Granulozytensystems.

First reported case of complete agranulocytosis.

1908 CE

#3080

Per la patogenesi e per la diagnosi delle malattie del sangue e degli organi emopoietici. Puntura esplorativa del midollo osseo.

Introduction of bone marrow biopsy by puncturing the shaft of the tibia.

1911 CE

#3081

Haemophilia.

Bulloch and Fildes, in their detailed account of hemophilia, claimed to have established immunity to the disease in females, and denied the authenticity of published cases of female hemophilia. They confirmed the law …

1911 CE

#3082

Grundriss der hämatologischen Diagnostik.

One of the leaders in modern hematology, Pappenheim improved the methods of staining blood cells.

1915 CE

#3083

Die essentielle Thrombopenie (konstitutionelle Purpura-Pseudo-Hämophilie).

Frank’s essential thrombopenia.

1918 CE

#3084

Zur Therapie der Polyzythämie.

Phenylhydrazine hydrochloride first used in the treatment of polycythemia.

1921 CE

#3085

Studies of the suspension stability of the blood in pulmonary tuberculosis.

Westergren’s method of measuring the erythrocyte sedimentation rate.

1922 CE

#3086

Gangräneszierende Prozesse und Defekt des Granulocytensystems.

“Schultz’s syndrome” – first description of agranulocytic angina. Schultz reported four cases of necrotic ulcerative infection of the throat with complete or almost complete disappearance of po…

1923 CE

#3087

Die Sternumtrepanation, ein einfache Methode zur diagnostischen Entnahme von Knochenmark bei Lebenden.

Bone marrow biopsy by sternal puncture.

1927 CE

#3088

"Methodology of examining bone marrow in live patients, with haemopoietic disease."

Needle puncture of bone marrow biopsy. (In Russian.) German account in Folia haemat. (Lpz.), 1929, 38, 233-40. English translation from the German in Bick, Classics of orthopaedics, 339-44.

1928 CE

#3089

Demonstratie van een paar zeldzaam voorkomende typen van bloedlichaampjes en bespreking der patiënten.

See No. 3092.

1929 CE

#3090

The velocity of blood flow in health and disease as measured by the effect of histamine on the minute vessels.

Measurement of circulation time.

1931 CE

#3091

Eine klinisch brauchbare Bestimmungsmethode der Blutumlaufszeit mittels Decholininjektion.

The decholin method for estimation of circulation time. With J. Deutsch and Z. Brull.

1931 CE

#3092

Over een familiaire anomalie der leucocyten.

Pelger–Huët anomaly of the nuclei of the leucocytes; see also No. 3089. German translation in Klin. Wschr., 1932, 11,1264-66.

1934 CE

#3093

The haemostatic possibilities of snake-venom.

Snake venom used in the treatment of hemophilia.

1934 CE

#3094

Sternal puncture; preliminary note.

Needle for sternal puncture.

1935 CE

#3095

The prothrombin in hemophilia and in obstructive jaundice.

Quick’s method for determination of prothrombin clotting time. See also Amer. J. med. Sci.,1935, 190,501-11.

1935 CE

#3096

A standardized technique for the blood sedimentation test.

Wintrobe’s method for the determination of the erythrocyte sedimentation rate.

1938 CE

#3097

The use of vitamin K and bile in treatment of the haemorrhagic diathesis in cases of jaundice.

Vitamin K used in the treatment of hemorrhagic disease.

1939 CE

#3098

Studies on leukemia with the aid of radioactive phosphorus.

Therapeutic use of radioactive isotopes for the treatment of leukemia. John H. Lawrence was the brother of Ernest Orlando Lawrence, inventor of the cyclotron; John Lawrence also worked at the Lawrence Berkeley Nationa…

1940 CE

#3099

Nuclear physics and therapy: preliminary report on a new method for the treatment of leukemia and polycythemia.

Radio-phosphorus in treatment of leukemia.