Entry Nos. 1100–1199

1935 CE

#1152

Chemical studies on the adrenal cortex. II. Isolation of several physicologically inactive crystalline compounds from active extracts. III. Isolation of two new physiologically inactive compounds.

Isolation of Compound F, identical with Kendall’s Compund E. See No. 1151.

1936 CE

#1153

Über Bestandteile der Nebennieren-Rinde. VI. Trennungsmethoden sowie Isolierung der Substanzen Fa, H, und j.

Isolation of Compound Fa, identical with Compounds E and F. "In the mid-1930s Edward Kendall and Tadeus Reichstein succeeded in isolating and analyzing the composition of a number of similar hormones derived from the …

1937 CE

#1154

Corticosteron, a crystallized compound with the biological activity of the adrenal-cortical hormone.

Isolation of corticosterone. With E. Laqueur, T. Reichstein, R. W. Spanhoff, and I. E. Uyldert.

1949 CE

#1155

Isolation of nor-adrenaline from the adrenal gland.

With U.S. von Euler and U. Hamberg. See also fuller account in Acta physiol. scand., 1950, 20, 101-8. Noradrenaline was independently isolated by B. F. Tullar, Science, 1950, 109, 536-7.

1838 CE

#1156

Ueber die Entstehung der Glandula pituitaria.

Important description of the pituitary.

1892 CE

#1157

Sulla distruzione della ghiandola pituitaria.

Vassale and Sacchi showed water and mineral metabolism to be affected by hypophysectomy.

1908 CE

#1158

L’hypophyse du cerveau. I. Physiologie.

Paulesco found that the removal of the anterior pituitary had fatal results, while removal of the posterior lobe had negative results.

1909 CE

#1159

The action of extracts of the pituitary body.

Oxytocic action of posterior pituitary injection.

1910 CE

#1160

Experimental hypophysectomy.

First experimental evidence of the relationship between the pituitary and the reproductive system; demonstration that hypophysectomy causes genital atrophy.

1910 CE

#1161

The functions of the pituitary body.

See No. 3896.

1912 CE

#1162

Über die Funktion der Hypophyse.

Aschner was able to keep his hypophysectomized dogs alive indefinitely. He found that they developed genital hypoplasia.

1921 CE

#1163

The effect of the anterior lobe administered intraperitoneally upon growth, maturity and oestrus cycles of the rat.

Evans and Long discovered the growth hormone of the anterior pituitary, showing that continued injections of an anterior pituitary extract produced an acceleration in the growth-rate of laboratory animals.

1922 CE–1923 CE

#1164

Evaluation of the hormone of the infundibulum of the pituitary gland in terms of histamine, with experiments on the action of repeated injections of the hormone on the blood pressure.

1923 CE–1924 CE

#1165

Further investigations on the oxytocic-pressor-diuretic principle of the infundibular portion of the pituitary gland.

1927 CE

#1166

The induction of precocious sexual maturity by pituitary homeotransplants.

Smith was able to induce precocious sexual maturity in mice and rats by the implantation of pituitary tissue.

1927 CE

#1167

Experimental evidence regarding the rôle of the anterior pituitary in the development and regulation of the genital system.

Pituitary tissue implanted in the immature mouse was found by these writers to cause precocious sexual maturity. Thus they showed that the activity of the gonads is maintained by the anterior lobe of the pituitary.

1927 CE

#1168

Das Hormon des Hypophysenvorderlappens.

Isolation of the gonadotrophic hormone of the anterior pituitary (Prolan A & B).

1930 CE

#1169

La diabetes pancreática de los perros hipofisoprivos.

Houssay’s depancreatized hypophysectomized dog. This work led to Houssay’s demonstration of the importance of the anterior pituitary in sugar metabolism. See also Endocrinology, 1931,15, 511-23. In 1947 Ho…

1933 CE

#1170

The adrenotropic hormone of the anterior pituitary lobe.

Isolation of an impure “adrenotropic hormone” containing adrenocorticotropic principle. With E. M. Anderson and D. L. Thomson.

1933 CE

#1171

The preparation, identification and assay of prolactin – a hormone of the anterior pituitary.

With R. W. Bates and S. W. Dykshorn.

1936 CE–1939 CE

#1172

The physiology and pharmacology of the pituitary body. 2 vols.

Includes an extensive bibliography.

1937 CE

#1173

Permanent experimental diabetes produced by pituitary (anterior lobe) injections.

Anterior pituitary diabetogenic hormone.

1943 CE

#1174

Adrenocorticotropic hormone.

Choh Hao Li and colleagues Isolated pure adrenocorticotropic hormone (ACTH) from sheep pituitary glands.

1943 CE

#1175

Preparation and properties of pituitary adrenocorticotropic hormone.

Isolation of ACTH from swine pituitaries.

1849 CE

#1176

Transplantation der Hoden.

Berthold showed that transplantation of a cock’s testes to another part of the body prevented atrophy of the comb, the usual sequel to castration. He was thus the first to prove the existence of an internal secr…

1889 CE

#1177

Expérience démontrant la puissance dynamogénique chez l’homme d’un liquide extrait de testicules d’animaux.

Brown-Séquard injected into himself a testicular extract in order to bring about rejuvenation. He reported much benefit but his advocacy of this method evoked scepticism and criticism, although it stimulated re…

1891 CE

#1178

On spermin.

Isolation of spermin from the testis.

1896 CE

#1179

Ueber die Bildung des Corpus luteum bei der Maus.

1905 CE–1906 CE

#1180

An experimental enquiry into the factors which determine the growth and activity of the mammary glands.

In their classic paper on the mammary gland, these workers attributed its changes during pregnancy to the fetus.

1908 CE

#1181

Der Bau der Uterusschleimhaut des geschlechtsreifen Weibes besonderer Berücksichtigung der Menstruation.

First definite description of the cyclical changes in the endometrium, which were shown to be a normal physiological process.

1917 CE

#1182

The existence of a typical oestrus cycle in the guinea-pig; with a study of its histological and physiological changes.

The vaginal smear test for estrus; it demonstrates the histological changes occurring in the vagina during the menstrual cycle.

1923 CE

#1183

An ovarian hormone.

Isolation of the active principle of the ovarian hormone (oestrin). More detailed account in J. biol. Chem., 1924, 61, 711-23.

1924 CE

#1184

The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone.

Test for recognition of the estrus hormone.

1927 CE

#1185

The menstrual cycle of the monkey, Macacus rhesus. Observations on normal animals, the effects of removal of the ovaries and the effects of injection of ovarian and placental extracts into the spayed animals.

This paper marks the beginning of modern knowledge of the menstrual cycle. Allen showed that uterine bleeding occurs as a withdrawal effect when estrogen ceases to act on the endometrium.

1927 CE

#1186

Über das Vorkommen weiblichen Sexualhormons (Menformon) im Harn von Männern.

Discovery of the estrogenic activity of male urine. With E. Dingemanse, P. C. Hart, and S. E. de Jongh.

1927 CE

#1187

The effect of the injection of a lipoid fraction of bull testicle in capons.

McGee prepared the first active male hormone extract from the lipoid fraction of bull testes. His paper includes a preliminary account of the capon-comb test. See No. 1191.

1929 CE

#1188

Physiology of the corpus luteum.

Discovery of the corpus luteum hormone, progesterone.

1929 CE

#1189

The male hormone.

Funk and Harrow obtained crude active male hormone extracts from male urine.

1929 CE

#1190

The chemistry of oestrin. I. Preparation from urine and separation from an unidentified solid alcohol.

Isolation of pregnanediol.

1929 CE

#1191

The effects of extracts of testis in correcting the castrated condition in the fowl and in the mammal.

C. R. Moore, T. F. Gallagher, and F. C. Koch were the first to obtain a potent testicular extract containing the male sex hormone, androsterone, later obtained in crystalline form by Butenandt. They also gave a detail…

1930 CE

#1192

The ovary-stimulating hormone of the placenta.

Collip’s anterior-pituitary-like (A-L-P) factor.

1930 CE

#1193

The preparation of the crystalline ovarian hormone from the urine of pregnant women.

First isolation of a pure crystalline hormone (estrone). Preliminary communication in Amer. J. Physiol., 1929, 90, 329-30.

1930 CE

#1194

The chemistry of oestrin. III. An improved method of preparation and the isolation of active crystalline material.

Crystalline estriol obtained.

1931 CE

#1195

Ueber die chemische Untersuchung der Sexualhormone.

The male sex hormone, androsterone, was isolated in crystalline form by Butenandt. In 1939 Butenandt received half of the Nobel Prize in Chemistry "for his work on sex hormones." The other half was awarded to Leopold …

1931 CE

#1196

Die Hormone des Ovariums und des Hypophysenvorderlappens.

Second edition, 1935.

1932 CE

#1197

Sex and internal secretions; a survey of recent research.

Second edition, 1939, with C. H. Danforth and E. A. Doisy.

1933 CE

#1198

Chemical and physiological properties of crystalline oestrogenic hormones.

Estriol obtained from placental tissue.

1933 CE

#1199

Die Behandlung der Amenorrhoë mit hohen Dosen der Ovarialhormone.

First use of estrogenic hormone for the treatment of amenorrhea in ovariectomized women, with production of the typical cyclical endometrial changes.