Facets

1948 CE

#3977

Experimental diabetes produced by the administration of glucose.

Experimental diabetes produced by artificially-induced hyperglycemia.

1927 CE

#1167

Experimental evidence regarding the rôle of the anterior pituitary in the development and regulation of the genital system.

Pituitary tissue implanted in the immature mouse was found by these writers to cause precocious sexual maturity. Thus they showed that the activity of the gonads is maintained by the anterior lobe of the pituitary.

1915 CE

#3848

Experimental hyperthyroidism.

First successful experimental production of exophthalmic goitre. With C. A. L. Binger and R. Fitz.

1910 CE

#1160

Experimental hypophysectomy.

First experimental evidence of the relationship between the pituitary and the reproductive system; demonstration that hypophysectomy causes genital atrophy.

1873 CE

#2588

Experimental researches on the causes and nature of catarrhus aestivus.

Blackley showed that pollen can produce hay fever in both the asthmatic and catarrhal forms; he also showed that skin reactions were evoked in sensitive persons.

1958 CE

#4011.1

Experimental ringworm in guinea pigs: oral treatment with griseofulvin.

Use of griseofulvin in the treatment of ringworm.

1889 CE

#5620

Experimental surgery.

Senn made important experimental studies on air embolism, introduced a method of diagnosing intestinal perforation by means of insufflation of hydrogen (see No. 3494), and used X-rays in the treatment of leukemia. He …

1888 CE

#2542

Experimente über die bacterienfeindlichen Einflüsse des thierischen Körpers.

Working with the defibrinated blood of certain animals, Nuttall was the first to describe the bactericidal action of blood. Abridged English translation in Bibel, Milestones in immunology (1988).

1908 CE

#3079.1

Experimentelle Leukämie bei Hühnern.

Cell-free transmission of fowl leukemia. Ellermann and Bang produced leukemia by means of a filterable agent.

1903 CE

#2628

Experimentelle Untersuchungen über Krebs bei Mäusen.

Jensen carried rat sarcoma through as many as 40 generations of rodents without change in microscopic structure. His classic study discredited the theory of the infectivity of cancer, and established its inoculability…

1776 CE

#3928

Experiments and observations on the urine in a diabetes.

Dobson proved that the sweetish taste of diabetic urine was produced by sugar, an observation following on Willis’s discovery of the sweetness of diabetic urine. He also discovered hyperglycemia.

1934 CE

#2605.1

Experiments in silk hypersensitivity and the inhalation of allergen in atopic dermatitis (neurodermatitis disseminatus).

Proof that inhaled allergens can reach the skin in a quantity and quality capable of eliciting urticarial reactions. With W.T. Vaughn. Coca and Sulzberger coined the term, “atopic dermatitis.”

1942 CE

#2578.3

Experiments on transfer of cutaneous sensitivity to simple compounds.

Cellular transfer of delayed hypersensitivity, establishing the criticial role of mononuclear cells in cellular immunity.

1979 CE

#13980

Expression in Escherichia coli of chemically synthesized genes for human insulin (plasmid construction / lac operon / fused proteins / radioimmunoassay / peptide purification).

Working at Genentech, Kleid and Goeddel and colleagues were the first scientists to apply genetic engineering techniques, incorporating chemically synthesized DNA encoding human insulin into E. coli, that expressed, a…

1863 CE

#6052

Exstirpation de l’utérus et des ovaires.

First successful excision of uterus and ovaries for tumor.

1878 CE

#3826

Exstirpation einer Struma retroesophagea.

Kocher, a pupil of Billroth, was a pioneer of thyroidectomy for goitre. Before his time the operation was seldom performed. Garrison says that Kocher performed this difficult operation 2,000 times, with a mortality ra…

1899 CE

#2624

Fall af epiteliom behandladt med Roentgenstraler.

In June 1899 Sjögren was the first successfully to use Roentgen rays in the treatment of cancer.

1863 CE

#4054

Fall einer selten Muskelkrankheit.

First recorded case of dermatomyositis, now regarded as a connective tissue disease.

1907 CE

#4141

Fall zur Diagnose (Poikiloderma vascularis atrophicans).

First description.

1939 CE

#4152.1

Familial benign chronic pemphigus.

“Hailey–Hailey disease”, earlier described by H. Gougerot, Arch. derm. – syph. Clin. St Louis, 1933, 5, 255-57.

1903 CE

#3920

Familiäre Cystindiathese.

Cystinosis described.

1891 CE

#3069.1

Farbenanalytische Untersuchungen zur Histologie und Klinik des Blutes.

Extension of Ehrlich’s work on the differential blood count. By means of his methods of staining blood cells Ehrlich differentiated two types of leukemia, lymphatic and myelogenous.

2009 CE

#9817

Fatal thirst: Diabetes in Britain until insulin.

1970 CE

#2660.26

Field trials with an attentuated cell associated vaccine for Marek's disease.

In 1959 Biggs moved to the Houghton Poultry Research Station (HPRS) to form and head a unit to study lymphoid tumor conditions of the domestic fowl. He gave the name Marek’s disease to one of the tumor condition…

1642 CE

#7879

Figura ductus cuiusdam cum multiplicibus suis ramulis noviter in pancreate in diversis corporibus humanis observati.

Wirsung, assistant to the celebrated German anatomist Johann Vesling, discovered the excretory duct of the pancreas named for him in 1642. To announce his discovery, Wirsung chose the extremely unusual method of publi…

1892 CE

#186

Finger prints.

The use of fingerprints as identification marks was known to the Chinese, but Galton was among the first to explain their possibilities in the identification of criminals. “Galton’s delta” is a trian…

1957 CE

#2660.9

Fluorinated pyrimidines, a new class of tumour-inhibitory compounds.

Synthesis of 5-fluorouracil. With eight co-authors.

1888 CE–1889 CE

#4094

Folliculite épilante décalvante.

Folliculitis decalvans of Quinquaud first described. At about the same time, P. A. Robert described it independently in his thesis, Paris, 1889.

2009 CE

#7655

Forces of form. Laurens de Rooy and Hans van den Bogaard (photographs). Compliled and edited by Simon Knepper, Johan Kortenray, Antoon Moorman.

A visually spectacular panorama of extraordinary color photographs, with significant historical and interpretive text, of the Vrolik Museum at the University of Amsterdam, collected by Gerard Vrolik and his son Willem…

1956 CE

#2353.1

Freeze-dried B.C.G. vaccination of newborn infants with a British vaccine.

Freeze-dried B.C.G. vaccine.

1975 CE

#2660.27

From the molecular biology of oncogenic DNA viruses to cancer. Les Prix Nobel en 1975, pp. 172-80.

In 1975 Dulbecco shared the Nobel Prize in Physiology or Medicine with David Baltimore and Howard Martin Temin "for their discoveries concerning the interaction between tumour viruses and the genetic material of the c…

1886 CE

#1129

Functional nervous disorders due to loss of thyroid gland and pituitary body.

First successful experimental hypophysectomy; two dogs survived five and six months respectively after this operation.

1886 CE

#3835

Functional nervous disorders due to the loss of thyroid gland and pituitary body.

1916 CE

#2570

Further experimental studies on the inheritance of susceptibility to a transplantable tumour, carcinoma (J. W. A.) of the Japanese waltzing mouse.

Marks the beginning of the study of histocompatibility antigens.

1916 CE

#2642

Further investigations on the origin of tumours in mice. III. On the part played by internal secretion in the spontaneous development of tumours.

Demonstration of the influence of an internal secretion on the development of spontaneous cancer. Castration of female mice of a strain in which mammary cancer was frequent reduced its incidence and delayed its growth.

1923 CE–1924 CE

#1165

Further investigations on the oxytocic-pressor-diuretic principle of the infundibular portion of the pituitary gland.

1911 CE

#2600.4

Further observations on the treatment of hay fever by hypodermic inoculations of pollen vaccine.

See No. 2600.3.

1927 CE

#1148

Further studies on adrenal insufficiency in dogs.

Cortical hormone first obtained.

1917 CE

#3921.1

Galaktosurie nach Milchzuckergabe bei angeborenen, familiärem, chronischem Leberleiden.

First clear account of galactosemia (although A. von. Reuss may have been describing a case in Wien. med. Wschr., 1908, 58, 799).

2015 CE

#11848

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.

Order of authorship in the original publication: Whitworth, Rowland, Ewen, ... Prather. Using the CRISPR Cas molecular gene-editing tool, Prather and colleagues edited the gene that codes for the CD163 protein in adul…

1965 CE

#4154.8

Genetic classification of ichthyosis.

Sex-linked recessive ichthyosis shown to be an important but not uncommon entity. See also Kerr & Wells: Sex-linked ichthyosis. Ann. hum. Genet., 1965, 29, 33-50.

1937 CE

#3876

Genital abnormalities, hermaphroditism and related adrenal diseases.

1893 CE–1915 CE

#2545

Gesammelte Abhandlungen zur ätiologischen Therapie von ansteckenden Krankheiten. 2 vols.

Digital facsimile from the Internet Archive at this link.

1904 CE

#2559

Gesammelte Arbeiten über Immunitätsforschung.

Reprints Ehrlich’s writings on immunology to date, as well as three papers by Kyes (Nos. 2111-3). English translation, with two more chapters by Ehrlich and Sachs, and one by Ehrlich, New York, 1906.

1912 CE

#86

Gesammelte Werke von Robert Koch. Unter Mitwirkung von G. Gaffky and E. Pfuhl. Herausgegeben von J. Schwalbe. 2 vols. [in 3).

For his work on tuberculosis Koch received the Nobel Prize in 1905. Digital facsimile from the Internet Archive at this link. See T.D. Brock, Robert Koch: A life in medicine and bacteriology, Madison, WS: Science-Tech…

1979 CE–1983 CE

#2581.10

Geschichte der Allergie. 4 vols.

2013 CE

#12580

Geschichte der Dermatologie in Deutschland.

1928 CE

#4155

Geschichte der Dermatologie, geographische Verteilung der hautkrankheiten Nomenklatur. (Handbuch der Haut- und Geschlechtskrankheiten, Bd. 14, 2. T.)

2001 CE–2013 CE

#8477

Geschichte der Histopathologie. 2 vols.

Traces development of microscopy in disease research and diagnostics, as applied in surgical, gynecological, and dermatologic pathology in the 19th and 20th centuries.

1996 CE

#12838

Geschichte der Hypophysenhormone.