Facets

1844 CE

#806

Neurologische Erlauterungen.

Remak was first to describe the intrinsic ganglia of the heart.

1660 CE

#914

New experiments physico-mechanical touching the spring of the air.

Boyle showed the effects of the elasticity, compressibility, and weight of air. He investigated the function of air in respiration, combustion, and conveyance of sound. Most significantly Boyle demonstrated that air i…

1987 CE

#1588.24

Nineteenth century origins of neuroscientific concepts.

Detailed analysis, emphasizing first half of 19th century, with detailed bibliographies, and bibliographical notes.

1977 CE

#14248

Nitric oxide activates guanylate cyclase and increases guanosine 3',5'-monophosphate levels in various tissue preparations.

Murad demonstrated that nitroglycerin and related drugs worked by releasing nitric oxide into the body, which relaxed smooth muscle by elevating intracellular cyclic GMP. With W. P. Arnold, C. K. Mittal, S. Katsuki. I…

2015 CE

#14260

NOBEL LECTURE: Discovery of Artemisinin - A gift from traditional Chinese medicine to the world.

In 1972 Tu Youyou discovered Artemisinin, the standard treatment worldwide for P. falciparum malaria as well as malaria due to other species of Plasmodium. Artemisinin is extracted from Artemisia annua (sweet wormwood…

2017 CE

#9712

Normality. A critical genealogy.

Perhaps the first study of the history of the "normal" in medicine. Traces the concept of normal to French anatomical and physiological discourse in the 1820s and 1830s, and its dissemination in modern culture through…

1897 CE–1938 CE

#513

Normentafeln zur Entwicklungsgeschichte der Wirbelthiere. 16 pts.

1885 CE

#1281

Note on the nature of nerve-force.

1854 CE

#1325

Note sur la découverte de quelques-uns des effets de la galvanisation du nerf grand sympathique au cou.

1896 CE

#1569.1

Note sur la variation éléctrique (courant d’action) déterminée dans le nerf acoustique par le son.

Beauregard and Dupuy recorded the action potential in the auditory nerve of the frog.

1854 CE

#11549

Notes of M. Bernard's lectures on the blood; with an appendix by Walter F. Atlee.

This record of Bernard's actual lectures contains the first published description of Bernard's technique of right and left heart cathererization, a technique that Bernard invented. The appendix includes notes of lectu…

1982 CE

#10140

Novel proteinaceous infectious particles cause Scrapie.

In 1997 Prusiner was awarded the Nobel Prize in Physiology or Medicine "for his discovery of Prions - a new biological principle of infection." In his 1982 paper Prusiner proposed a completely novel explanation for th…

1705 CE

#2729

Novum vasorum corporis humani systema.

Vieussens was among the first to describe the morbid changes in mitral stenosis, the throbbing pulse in aortic insufficiency, and the first correctly to describe the structure of the left ventricle, the course of the …

1839 CE

#805

Nowe spostrzezenia i badainia w przedmiocie fizyologii i drobnowidzowéj anatomii.

The “Purkinjĕ fibres”; identification of the conductor system of the heart. Reprinted in his Opera omnia, 1939, 3, 52-63. German version in Arch. Anat. Physiol, wiss. Med., 1845, 281-95; English translatio…

1667 CE–1673 CE

#292.1

Observationes anatomicae selectiores. [Part II: Observationum anatomicarum… pars altera]. 2 vols.

The only publications of one of the earliest scientific societies, active from 1664 to 1672. Founded by Gerard Blaes, and numbering Jan Swammerdam among its members, the college devoted itself to comparative anatomica…

1863 CE

#488

Observationes nonnulae de ovorum ranarum segmentatione, quae “Furchungsprocess” dicitur.

Best contemporary description of the segmentation furrowing of the egg.

1882 CE

#828

Observations on the direct influence of variations of arterial pressure upon the rate of beat of the mammalian heart.

1928 CE

#1059

Observations on the function of peroxidase systems and the chemistry of the adrenal cortex. Description of a new carbohydrate derivative.

Isolation of vitamin C, ascorbic acid. In 1937 Szent-Györgyi was awarded the Nobel Prize in Physiology or Medicine "for his discoveries in connexion with the biological combustion process with special reference t…

1907 CE

#521

Observations on the living developing nerve fiber.

Harrison demonstrated the development of nerve fibres by independent growth from cells outside the organism.

1877 CE–1880 CE

#632

Observations on the locomotor system of Medusae. 3 pts.

Charles Sherrington described the significance of Romanes' research on jellyfish in terms of its impact on cardiac physiology: "Romanes's observations carried out with simple means were novel and fundamental. The ques…

1882 CE

#12264

Observations on the mean pressure and the characters of the pulse wave in the coronary arteries of the heart.

1700 CE

#11894

Observations sur la maniere de tailler dans les deux sexes pour l'extraction de la pierre, pratiqué par Frere Jacques. Nouveau system de la circulation du sang pour le trou ovale dans le foetus humain, avec les réponses aux objections qui ont été faites contre cette hypothese.

"Méry became closely associated with the comparative-anatomical work led by Claude Perrault and J.-G. Duverney. As a member of this group, Méry made contributions to their joint publications, in which ea…

1773 CE

#589

Of the electric property of the torpedo.

The first accurate study of the electrical organs of the torpedo fish were made by Walsh, who was given the Copley Medal of the Royal Society for his work on the subject. Walsh proved that the shock of the torpedo was…

1896 CE

#2000

Om anvendelse medicinen af koncentrerede kemiske lysstraaler.

Finsen was the founder of modern phototherapy. He demonstrated the value of invisible light, the actinic or chemical ray, the ultra-violet ray, as therapeutic measures. Digital facsimile from wellcomecollection.org at…

1881 CE

#827

On a method of isolating the mammalian heart.

Martin devised a form of perfusion of the isolated mammalian heart – one of the greatest single contributions ever to come from an American physiological laboratory. This made possible his later work on the hear…

1830 CE

#600

On a peculiar motion excited in fluids by the surfaces of certain animals.

Sharpey was the first occupant of the chair of anatomy and physiology at University College, London, this chair being the first official recognition of physiology in any English medical school. He wrote a memorable pa…

1854 CE

#686

On osmotic force.

Investigation of osmotic force; provided important information for the physiologists.

1849 CE

#13704

On parthenogenesis, or the successive production of procreating individuals from a single ovum. A discourse introductory to the Hunterian Lectures on Generation and Development for the year 1849, delivered at the Royal College of Surgeons of England.

Digital facsimile from Google Books at this link.

1914 CE

#851

On some cardiac reflexes.

Bainbridge found that cardiac reflex action is produced by inhibition of vagus tone and excitation of the accelerator nerves.

1897 CE

#5247

On some peculiar pigmented cells found in two mosquitoes fed on malarial blood.

Ross proved that the mosquito was responsible for the transmission of malaria. On 20 August 1897, he found Laveran’s Plasmodium in the stomach of the Anopheles mosquito after it had fed on the blood of malaria p…

1913 CE

#849

On the action of drugs and the function of the anterior lymph hearts in cardiectomized frogs.

Abel was one of America’s most distinguished pharmacologists. See A. M. Harvey. "Pharmacology’s giant," Johns Hopk. med. J., 1974, 135, 245-58.

1963 CE

#14069

On the aims and methods of ethology.

In this paper Tinbergen defined Tinbergen's Four Questions, or complementary categories of explanations for animal behavior. that form the basis of ethology: Causation, Ontogeny, Survival Value, and Evolution. In 1973…

1866 CE–1868 CE

#336

On the anatomy and physiology of the vertebrates. 3 vols.

Vol. 1. Fishes and reptiles; Vol. 2. Birds; Vol. 3. Mammals. The most important work on the subject after Cuvier, based entirely on personal observations. Owen entitled his 40th and concluding chapter "Derivative hypo…

1929 CE

#1933

On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae.

Discovery of the growth-inhibiting action of Penicillium on certain bacteria. In 1945 Fleming shared the Nobel Prize in Physiology or Medicine with Ernst Boris Chain and Sir Howard Walter Florey "for the discovery of …

1846 CE

#11558

On the disorders of the cerebral circulation; and on the connection between affections of the brain and diseases of the heart.

"Burrows was the first to indicate that the effects of cerebral anemia could be produced not only by obvious anemia itself, but also from a fall in blood pressure. He carried out some of the earliest studies of the ph…

1883 CE–1884 CE

#831

On the electrical phemomena of the excitatory process in the heart of the frog and of the tortoise, as investigated photographically.

See No. 824. This paper contains several tracings of the heart's electrical activity recorded with a capillary electrometer, the earliest graphic recorder of bioelectric signals. These were the "first undistorted trac…

1857 CE

#619

On the formation of the skeletons of animals, and other hard structures formed in connexion with living tissues.

Includes description of “Rainey’s tubes” or “corpuscles” in connexion with the process of calcification of tissues.

1832 CE

#12197

On the influence of physical agents on life, by W. F. Edwards. Translated from the French by Dr. Hodgkin and Dr. Fisher. To which are added, in the appendix, some observations on electricity by Dr. Edwards, M. Pouillet, and Luke Howard; on absorption, and the uses of the spleen, by Dr. Hodgkin; on the microscopic characters of the animal tissues and fluids, by J. J. Lister and Dr. Hodgkin, and some notes to the work of Dr. Edwards.

Digital facsimile from Google Books at this link.

1883 CE

#1279

On the influence of the galvanic current on the excitability of the motor nerves of man.

1914 CE

#850

On the influence of the lymph hearts upon the action of convulsant drugs in cardiectomized frogs. II.

1883 CE–1884 CE

#830

On the innervation of the heart, with special reference to the heart of the tortoise.

Gaskell showed that the efferent vasoconstrictor fibers of the heart originated from the lateral horn of the spinal cord.

1889 CE

#1329.1

On the local paralysis of peripheral ganglia, and on the connexion of different classes of nerve fibres with them.

Langley and Dickinson studied the effect of nicotine on nerve fibers, and were able by this means to make a thorough investigation of the distribution of nerve fibers.

1891 CE

#1420.1

On the mammalian nervous system, its functions, and their localisation determined by an electrical method.

Gotch and Horsley showed that electric currents are produced in the mammalian brain, and they recorded them with the string galvanometer of the capillary electrometer. Their work led eventually to the development of t…

1900 CE

#839

On the muscular architecture and growth of the ventricles of the heart.

A classic account of the development and architecture of the muscular wall of the heart.

1911 CE

#12262

On the muscular architecture of the ventricles of the human heart.

1916 CE

#569

On the natural faculties. With an English translation by Arthur John Brock.

Greek-English edition in the Loeb Classical Library. This was one of the first, if not the actual first, modern English translations of Galen. Digital facsimile from the Internet Archive at this link.

1899 CE

#515.1

On the nature of the process of fertilization and the artificial production of normal larvae (plutei) from the unfertilized eggs of the sea urchin.

Loeb first achieved parthenogenesis in 1899.

1871 CE

#626

On the physiological effects of severe and protracted muscular exercise; with special reference to the influence of exercise upon the excretion of nitrogen.

Flint made investigations on the nitrogen output of a long-distance walker, before, during, and after the latter’s attempt to walk 400 miles in five days. The useful data in this paper are often referred to in d…

1896 CE

#13072

On the pigment of the negro's skin and hair.

"In the present state of our knowledge we can only say that it seems highly probable that the pigment of the negro's hair is not different from the dark pigment found in the hair of the white races, and we may infer t…

1893 CE

#786

On the results of ligation of the coronary arteries.

“Following coronary ligation Porter noted that the procedure frequently resulted in fibrillary contractions of the heart and sudden death. However, death did not always occur and this led him to conclude that Co…