PRUSINER, Stanley Benjamin (1942 – )
1942 –
5 entries in the GMN corpus.
Image source Christopher Michel · Own work · CC BY 4.0
1982 CE
#10842
Identification of a protein that purifies with the Scrapie prion.
Research with the biochemist Bolton enabled Prusiner to discover and characterize the specific protein causing prion disease. This paper was dated December 24, 1982. Nearly simultaneously, Prusiner and the same co-aut…
1982 CE
#10140
Novel proteinaceous infectious particles cause Scrapie.
In 1997 Prusiner was awarded the Nobel Prize in Physiology or Medicine "for his discovery of Prions - a new biological principle of infection." In his 1982 paper Prusiner proposed a completely novel explanation for th…
1996 CE
#12835
Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity.
The authors showed that the " 'normal prion protein' in the brains of living mice can be converted into different forms depending on the type of abnormal human prion that initiated the conversion. The result is differ…
2004 CE
#12836
Synthetic mammalian prions.
The authors modified Koch's Postulates within the context of prion disease. To do so the followed these steps: 1) They created recombinant mouse prion proteins in an E. coli and polymerized them. 2) They proved that t…
2014 CE
#7624
Madness and memory: The discovery of prions- a new biological principle of disease.
Prusiner discovered prions, the agent causing scrapie in sheep and goats, mad cow disease, and Creutzfeldt-Jakob disease in humans.