Facets

1980 CE

#7455

Mutations affecting segment number and polarity in Drosophilia.

In 1995 Nüsslein-Volhard and Wieschaus shared the Nobel Prize in Physiology or Medicine with Edward B. Lewis "for their discoveries concerning the genetic control of early embryonic development."

1977 CE

#14248

Nitric oxide activates guanylate cyclase and increases guanosine 3',5'-monophosphate levels in various tissue preparations.

Murad demonstrated that nitroglycerin and related drugs worked by releasing nitric oxide into the body, which relaxed smooth muscle by elevating intracellular cyclic GMP. With W. P. Arnold, C. K. Mittal, S. Katsuki. I…

2015 CE

#14260

NOBEL LECTURE: Discovery of Artemisinin - A gift from traditional Chinese medicine to the world.

In 1972 Tu Youyou discovered Artemisinin, the standard treatment worldwide for P. falciparum malaria as well as malaria due to other species of Plasmodium. Artemisinin is extracted from Artemisia annua (sweet wormwood…

1982 CE

#10140

Novel proteinaceous infectious particles cause Scrapie.

In 1997 Prusiner was awarded the Nobel Prize in Physiology or Medicine "for his discovery of Prions - a new biological principle of infection." In his 1982 paper Prusiner proposed a completely novel explanation for th…

1928 CE

#1059

Observations on the function of peroxidase systems and the chemistry of the adrenal cortex. Description of a new carbohydrate derivative.

Isolation of vitamin C, ascorbic acid. In 1937 Szent-Györgyi was awarded the Nobel Prize in Physiology or Medicine "for his discoveries in connexion with the biological combustion process with special reference t…

1896 CE

#2000

Om anvendelse medicinen af koncentrerede kemiske lysstraaler.

Finsen was the founder of modern phototherapy. He demonstrated the value of invisible light, the actinic or chemical ray, the ultra-violet ray, as therapeutic measures. Digital facsimile from wellcomecollection.org at…

1897 CE

#5247

On some peculiar pigmented cells found in two mosquitoes fed on malarial blood.

Ross proved that the mosquito was responsible for the transmission of malaria. On 20 August 1897, he found Laveran’s Plasmodium in the stomach of the Anopheles mosquito after it had fed on the blood of malaria p…

1963 CE

#14069

On the aims and methods of ethology.

In this paper Tinbergen defined Tinbergen's Four Questions, or complementary categories of explanations for animal behavior. that form the basis of ethology: Causation, Ontogeny, Survival Value, and Evolution. In 1973…

1929 CE

#1933

On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae.

Discovery of the growth-inhibiting action of Penicillium on certain bacteria. In 1945 Fleming shared the Nobel Prize in Physiology or Medicine with Ernst Boris Chain and Sir Howard Walter Florey "for the discovery of …

1942 CE

#14239

On the utilization of acetic acid for cholesterol formation.

See also, Rittenberg & Bloch, "The Utilization of Acetic Acid for the Synthesis of Fatty Acids," J. Biol. Chem. 160, 1945, 417-424. Bloch, "The Biological Conversion of Cholesterol to Pregnanediol," J. Biol. Chem. 157…

1563 CE–1564 CE

#1093

Opuscula anatomica.

Eustachius is credited with several anatomical discoveries, among them the tensor tympani muscle and the Eustachian tube, published in his chapter entitled De auditus organis. In the last respect, however, he was anti…

1940 CE

#1934

Penicillin as a chemotherapeutic agent.

Proof of the therapeutic action in vivo of penicillin against streptococcal and other bacterial infections. Building upon Fleming’s work (No. 1933 and 10784), the consequences of which had originally been widely…

2010 CE

#14275

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.

Patapoutian and colleagues characterized the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. With Mathur, J.; Schmidt, M.; Earley, T. J.; Ranade, S.; Petrus, M. J.; Dubin, A. E. See…

1890 CE

#3741

Polyneuritis bij hoenders.

Eijkman produced beriberi experimentally in fowls; from this he was led to conclude that a diet of over-milled rice was the chief cause, both in fowls and humans. Thus his work was of great importance in determining t…

1993 CE

#14301

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.

The authors cloned and generated the sequence of the lin-14 gene. They discovered that a segment in lin-14 mRNA (messenger RNA), was necessary for its inhibition by lin-4. Ruvkun and Ambros (No. 14010) then compared r…

1998 CE

#13957

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

The authors reported that tiny snippets of double-stranded RNA (dsRNA) effectively shut down specific genes, driving the destruction of messenger RNA (mRNA) with sequences matching the dsRNA. As a result, the mRNA can…

1995 CE

#14269

Purification and characterization of hypoxia-indicible factor 1.

Semenza and postdoctoral fellow Guang Wang discovered transcription factor HIF-1, a transcription factor that responds to decreases in available oxygen in the cellular environment, or hypoxia. IN 2019 Semenza shared t…

1959 CE

#14242

Receptive fields of single neurones in the cat's striate cortex.

Also: Hubel & Wiesel, Receptive fields, binocular interaction and functional architecture in the cat's visual cortex, J. Physiol., 160, 1962, 106-154. In 1981 Hubel and Wiesel shared half of the Nobel Prize in Physiol…

1910 CE–1911 CE

#5384

Recherches experimentales sur le typhus exanthématique.

Nicolle demonstrated the transmission of typhus by the body louse Pediculus corporis. He also produced the disease in monkeys and guinea-pigs by the injection of infected blood. Preliminary communication in C. R. Acad…

1800 CE

#597

Recherches physiologiques sur la vie et la mort.

When Volta questioned the validity of experiments claiming to show responsiveness of an ex vivo heart, devoid of blood flow and nervous connections, Bichat obtained permission to experiment upon the freshly killed bod…

1973 CE

#14241

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase activity in human fibroblasts by lipoproteins.

Goldstein and Brown discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develo…

1979 CE

#14247

Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

With CA Gruetter, BK Barry, DB McNamara, DY Gruetter, PJ Kadowitz. In 1998 Ignarro shared the Nobel Prize in Physiology or Medicine with Robert F. Furchgott and Ferid Murad "for their discoveries concerning nitric oxi…

1963 CE

#8149

Representation of a Function by its Line Integrals, with Some Radiological Applications.

Cormack showed that changes in tissue density could be computed from x-ray data. Because of limitations in computing power no machine was constructed during the 1960s. Cormack's papers generated little interest until …

1977 CE

#14143

Resolution of some components of adenylate cyclase necessary for catalytic activity.

Goodman shared the 1994 Nobel Prize in Physiology or Medicine with Martin Rodbell "for their discovery of G-proteins and the role of these proteins in signal transduction in cells." In this paper Goodman and Ross show…

1984 CE

#14265

Restoration of circadian behavioral rhythms by gene transfer in Drosophila.

"At The Rockefeller University in the early 1980s, Young and his two lab members, Ted Bargiello and Rob Jackson, further investigated the circadian period gene in Drosophila. They constructed segments of recombinant D…

1974 CE

#7453

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

Doherty and Zinkernagel discovered how a class of white blood cells known as T cells kill virus-infected cells in the body, and so present the spread of viruses. In 1998 Zinkernagel and Doherty were awarded the Nobel …

1970 CE

#2660.23

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…

1952 CE

#13938

Rôle des cations bivalents dans l'induction du développement du prophage par les agents reducteurs.

Lwoff gave the name "prophage" to the form in which the genome of the bacteriophage is perpetuated in lysogenic bacteria. The bacteriophages produced by these bacteria, known as temperate bacteriophages, can therefore…

1947 CE

#1534

Sensory mechanisms of the retina: with an appendix on electroretinography.

An account of twenty years’ work on the electrical responses of the retina, a discussion of visual purple and visual violet, and an exposition of Granit’s hypothesis of colour vision. His researches have d…

1958 CE

#2578.25

Separation and isolation of fractions of rabbit gamma-globulin containing the antibody and antigenic combining sites.

In 1972 Porter shared the Nobel Prize in Physiology or Medicine with G.M. Edelman (No. 2578.39) "for their discoveries concerning the chemical structure of antibodies."

1910 CE

#245.2

Sex-limited inheritance in Drosophila.

Morgan demonstrated sex-limited inheritance. In 1933 Morgan was awarded the Nobel Prize in Physology or Medicine "for discoveries elucidating the role that the chromosome plays in heredity." See also Nos. 245.3, 246, …

1976 CE

#7454

Single-channel currents recorded from membrane of denervated frog muscle fibres.

In 1991 Neher and Sakmann were awarded the 1991 Nobel Prize in Physiology or Medicine for "their discoveries concerning the function of single ion channels in cells." They were also awarded the prize for the invention…

1987 CE

#13931

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

In 2007 Capecchi shared the 2007 Nobel Prize in Physiology or Medicine with Martin J. Evans and Oliver Smithies "for their discoveries of principles for introducing specific gene modifications in mice by the use of em…

1971 CE

#6890

Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae.

Nathans showed that the restriction enzyme discovered by Hamilton Smith cleaved SV40 DNA into 11 specific pieces. Nathans and his student Kathleen Danna wrote: "The availability of pieces of SV40 DNA from specific sit…

1977 CE

#11044

Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significa…

1944 CE

#1935

Streptomycin, a substance exhibiting antibiotic activity against Grampositive and Gram-negative bacteria.

Introduction of streptomycin. Order of authorship: Schatz, Gregory, Waksman. In 1952 Waksman was awarded the Nobel Prize in Physiology or Medicine "for ingenious, systematic, and successful studies of the soil microbe…

1965 CE

#257.2

Structure of a ribonucleic acid.

The complete sequence of an alanine transfer RNA determined – the first nucleic acid structure to be determined. With seven co-authors. In 1968 Holley shared the Nobel Prize in Physiology or Medicine with Har Go…

1971 CE

#14231

Structure of the porcine LH-and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses.

Publication in May 1971: Working with pig preparations, the authors reinvestigated the peptide that they had previously isolated, which acted as an LH-FSH releasing hormone. They performed an Edman-dansyl degradation …

1952 CE

#3108.2

Studies on condensed pyrimidine system. IX. The synthesis of some 6-substituted purines.

Synthesis of 6-mercaptopurine. In 1988 Gertrude Elion shared the Nobel Prize in Physiology or Medicine with George Hitchings and Sir James Black “for their discoveries of important principles for drug treatment.…

1958 CE

#752.6

Studies on polynucleotides. I. A new and general method for the chemical synthesis of the C5'-C3' intemucleotide linkage. Synthesis of deoxyribo-dinucleotides.

In 1968 Khorana shared the Nobel Prize in Physiology or Medicine with R. W. Holley and M. W. Nirenberg "for their interpretation of the genetic code and its function in protein synthesis." H. G. Khorana, T. M. Jacob, …

1941 CE

#4276

Studies on prostatic cancer. I. The effect of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate.

In 1966 Huggins was awarded the Nobel Prize for Physiology or Medicine for discovering in 1941 "for his discoveries concerning hormonal treatment of prostatic cancer."

1956 CE

#4257

Successful homotransplantation of the human kidney between identical twins.

This was the first successful kidney transplant. The patient, both of whose own kidneys had been removed, was alive 11 months after the transplant. With Warren R. Guild. See No. 4256.1. In 1990 Joseph Murray shared th…

1886 CE

#1416

Sulla fina anatomia degli organi centrali del sistema nervoso.

Golgi’s histological studies made a clear conception of the nervous system possible for the first time. He demonstrated the existence of multipolar nerve-cells (Golgi cells) by means of his silver nitrate stain,…

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1987 CE

#13940

Targeted correction of a mutant HPRT gene in mouse embryonic stem cells.

Smithies discovered, simultaneously with Mario Capecchi and Martin Evans, the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previ…

1899 CE–1904 CE

#1293.1

Textura del sistema nervioso del hombre y de los vertebrados. 2 vols. in 3.

From publication in fascicules, 1897-1904 (vol. 1 in 3 pts., vol. 2 in 4 pts.) This monumental work set out the cytological and histological foundations of modern neurology. Ramón y Cajal’s research confi…

c. 1914 CE

#1340

The action of certain esters and ethers of choline, and their relation to muscarine.

Demonstration of the inhibitory action of acetylcholine on the heart. In 1936 Dale shared the Nobel Prize in Physiology or Medicine with Otto Loewi (No. 1343) "for their studies in the chemical mediation of nervous im…

1922 CE

#793

The anatomy and physiology of the capillaries.

Silliman Lectures. Krogh was first to describe the adaptation of blood perfusion in muscle and other organs according to demands through opening and closing the arterioles and capillaries. In 1920 Krogh received the N…

1928 CE

#1308

The basis of sensation. The action of the sense organs.

In 1932 Adrian shared the Nobel Prize in Physiology or Medicine with Charles Scott Sherrington "for their discoveries about the function of neurons." See also Nos. 1307, 1528, and 1303.

1993 CE

#14010

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA sil…