RUVKUN, Gary Bruce (1952 – )
1952 –
2 entries in the GMN corpus.
Image source John Sears · Own work · CC BY-SA 4.0
1993 CE
#14301
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.
The authors cloned and generated the sequence of the lin-14 gene. They discovered that a segment in lin-14 mRNA (messenger RNA), was necessary for its inhibition by lin-4. Ruvkun and Ambros (No. 14010) then compared r…
2000 CE
#14302
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.
Working with the let-7 gene, the authors led by Ruvkun showed that microRNA encoded by the let-7 gene was highly conserved, and present throughout the animal kingdom, proving that gene regulation by microRNA is univer…