Facets

1952 CE

#12032

A nonhereditary, host-induced variation of bacterial viruses.

Order of authorship in the original publication: Luria, Human. Luria and Human discovered the restriction modification system found in bacteria and other prokaryotic organisms. This system provides a defense against f…

1915 CE

#2571

An investigation on the nature of ultra-microscopic viruses.

Twort discovered discovered bacteriophages, a type of virus that attacks bacteria (the term bacteriophage was coined by Félix d’Herelle, who in 1917 independently confirmed Twort’s discovery). The d…

2003 CE

#10244

ArtandMedicine.com.

http://www.artandmedicine.com/Index.html A highly personal but in all aspects extraordinary website/blog on the history of medical photography in the form of what Rowley calls his Cabinet Journal.

1892 CE–1896 CE

#10621

Atlas of clinical medicine. 3 vols.

Published at the end of the 19th century, and employing the wide variety of illustration technologies then available, including color lithography, lithography, and photography, this work testifies to the breadth and d…

1865 CE

#6938

Catalogue de la superbe bibliothèque d'ethnographie, de zoologie, d'anatomie comparée, etc....

The auction catalogue of Vrolik's library, sold two years after his death, organized by subject. Prefaced by an essay about Vrolik's life and work by J. van der Hoeven, and a chronological list of Vrolik's publication…

1979 CE

#14007

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells.

Levine discovered the tumor suppressor protein p53, also known as Tumor protein P53. Because it prevents cancer formation TP 53 is classified as a tumor suppressor gene. The discovery was completed in 1989 and recorde…

2007 CE

#11843

CRISPR provides acquired resistance against viruses in prokaryotes.

Horvath and his team provided key details of the extremely complex mechanisms involved in CRISPR's function as an immune system for bacteria against bacteriophages. Analogous to Pasteur's heroic role in saving the Fre…

2020 CE

#13483

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

Posted online on February 17, 2020. 2019-nCoV was an interim name for the Novel Coronavirus. These studies, which included the 3D structure of the RBD (receptor binding domain) within the S protein, provided informati…

1924 CE

#562

Das reticulo-endotheliale System.

In an earlier paper on this subject (Münch, med. Wschr., 1922, 69, 1352-56) Aschoff introduced the term “reticulo-endothelial system”; as early as 1914 he grouped certain phagocytic cells into his sys…

1970 CE

#13730

Dermatologie in der Kunst.

2009 CE

#13029

Dermatology for skin of color.

"... the first comprehensive reference for this subspecialty, ranging from the historic and cultural to the clinical and basic science components....More than 600 full-color photographs of preoperative and postoperati…

1976 CE

#2660.28

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Discovery of the first “oncogene. In 1989 Varmus and Bishop shared the Nobel Prize for in Physiology or Medicine "for their discovery of the cellular origin of retroviral oncogenes."

1979 CE

#13980

Expression in Escherichia coli of chemically synthesized genes for human insulin (plasmid construction / lac operon / fused proteins / radioimmunoassay / peptide purification).

Working at Genentech, Kleid and Goeddel and colleagues were the first scientists to apply genetic engineering techniques, incorporating chemically synthesized DNA encoding human insulin into E. coli, that expressed, a…

1975 CE

#2660.27

From the molecular biology of oncogenic DNA viruses to cancer. Les Prix Nobel en 1975, pp. 172-80.

In 1975 Dulbecco shared the Nobel Prize in Physiology or Medicine with David Baltimore and Howard Martin Temin "for their discoveries concerning the interaction between tumour viruses and the genetic material of the c…

2015 CE

#11848

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.

Order of authorship in the original publication: Whitworth, Rowland, Ewen, ... Prather. Using the CRISPR Cas molecular gene-editing tool, Prather and colleagues edited the gene that codes for the CD163 protein in adul…

1968 CE

#12028

Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage FD replicative form.

Order of authorship in the original publication: Linn, Arber. Arber announced the discovery, with proof, of the first restriction endonuclease (restriction enzyme or restrictase)."These enzymes are found in bacteria a…

1962 CE

#12033

Host specificity of DNA produced by escherichia coli. II. Control over acceptance of DNA from infecting phage lambda.

Order of authorship in the original publication: Dussoix, Arber. The authors discovered that restriction of DNA from infecting bacteriophage was due to the attack and breakdown of the modified bacteriophage's DNA by s…

1973 CE

#11074

Identification of a novel cell type in peripheral lymphoid organs in mice. I. Morphology, quantitation, tissue distribution.

Order of authorship in the original publication: Steinman, Cohn. In this paper Steinman announced his discovery of the dendritic cell. Digital facsimile from PubMedCentral at this link. In 2011 Steinman received half …

1956 CE

#2578.17

Infectivity of ribonucleic acid from tobacco mosaic virus.

Proof that nucleic acid produces infectivity. See also Z. Naturf., 1956, 11b, 138-42.

2005 CE

#11842

Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements.

Order of authorship in the original publication: Mojica, Díez-Villaseñor, Jesus García-Martínez. In this paper Mojica and colleagues showed the the CRISPR system is a bacterial immune syste…

1834 CE

#13415

Mémoire comparatif sur l'histoire naturelle de l'insecte de la gale.

Raspail first described and illustrated the Sarcoptes scabei, diffrentiating it from the horse's sarcopt and the cheese moth that Galès and Patrix, followed by Alibert, had confused with the scabies parasite. R…

2006 CE

#9820

Mom's cancer.

This book was born digital in 2004, and later published in print. See www.momscancer.com. "Winner of the 2005 Eisner Award in the category of Best Digital Comic for the original Web version" "Brian Fies is a freelance…

1652 CE

#3737

Observationes medicae.

One of the earliest accounts of beri-beri is on pp. 300-05 of this work. Tulp, notable as the demonstrator in Rembrandt’s “Anatomy Lesson”, was among the first, in the same book, to describe the ileo…

1922 CE–1939 CE

#83

Œuvres de Pasteur, réunies par Pasteur Vallery-Radot. 7 vols.

One of the founders of bacteriology, Pasteur's work on fermentation, the doctrine of spontaneous generation (which he exploded), virus diseases and preventive vaccinations, was fundamental. Digital facsimile of the co…

1896 CE

#13072

On the pigment of the negro's skin and hair.

"In the present state of our knowledge we can only say that it seems highly probable that the pigment of the negro's hair is not different from the dark pigment found in the hair of the white races, and we may infer t…

1876 CE

#2127.1

Paraffin epithelioma of the scrotum.

Shale oil shown to be a cause of skin cancer. A teacher of Sir Arthur Conan Doyle, Bell was the model for the character of Sherlock Holmes.

1976 CE

#13976

Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m7G(5')ppp(5')GmpCp.

Furuichi, working in Shatkin's laboratory, discovered that the viral mRNAs synthesized in vitro by the virion-associated RNA polymerase of reovirus contain a unique 5′-terminal structure m7GpppNm or cap. The pre…

1970 CE

#2660.23

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1955 CE

#1207

The disulphide bonds of insulin.

Sanger sequenced the amino acids of insulin, the first of any protein. His work “revealed that a protein has a definite constant, genetically determined sequence—and yet a sequence with no general rule for…

1929 CE

#7186

The female sex hormone. Part I: Biology, pharmacology and chemistry. Part II: Clinical investigations based on the female sex hormone blood test.

The first handbook on female sex hormones. Digital facsimile from the Hathi Trust at this link.

2013 CE

#14101

The haplotype-resolved genome and epigenome of the aneuploidy HeLa cancer cell line.

Adey and colleagues sequenced the haplotype-resolved whole genome of the HeLa cancer cell line. This showed a highly rearranged region at chromosome 8q24.21, where an integration locus of the HPV (human papillomavirus…

2017 CE

#14102

The role of the WI-38 cell strain in saving lives and reducing morbidity.

In 1961 "Hayflick developed the first normal human diploid cell strains for studies on human aging and for research use throughout the world. Prior to his seminal research, all cultured cell lines were immortal and an…

1952 CE

#14100

Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium.

A cell biologist at Johns Hopkins Hospital, Gey propagated the HeLa cell line from Henrietta Lacks' cervical tumor. This cell line, which maintained a continuous growth phase, was the first immortal human cell line to…

1860 CE

#534.62

Untersuchungen über die Entstehung der Missbildungen Zunächst in den Eiem der Vögel.

The first monograph on experimental teratology.

1970 CE

#2660.22

Viral RNA-dependent DNA polymerase: RNA-dependent DNA polymerase in virions of RNA tumour viruses.

In 1970 Baltimore and Temin discovered that certain viruses that have their genes in the form of RNA can copy the RNA "backward" into DNA in infected cells. The enyzme, reverse transcriptase, enables the manufacture o…

1922 CE

#6609.1

Wunder, Wundgeburt und Wundergestalt in Einblattdrucken des 15-18. Jahrhunderts.

History of teratology in art from 15th to 18th centuries.

1914 CE

#7759

Zur Frage der Entstehung maligner Tumoren.

Boveri argued that malignancy arises as a consequence of chromosomal abnormalities, and that multiplication is an inherent property of cells. He predicted the existence of tumor suppressor mechanisms and was perhaps t…