Facets

1946 CE

#14138

Die Tänze der Bienen.

Von Frisch discovered the waggle dance, a particular figure-eight dance of honey bees by which successful foragers can communicate information with other members of their colony about the direction and distance to pat…

1893 CE

#836

Die Thätigkeit des embryonalen Herzens und deren Bedeutung für die Lehre von der Herzbewegung beim Erwachsenen.

His described the atrioventricular bundle which was later named after him. English translation in F. A. Willius and T. E. Keys, Cardiac classics, 1941, p. 695.

1910 CE

#740

Die Theorie des Haftdrucks (Oberflächendrucks) und ihre Bedeutung für die Physiologie.

1928 CE

#798

Die Thermo-Stromuhr. Ein Verfahren zur fortlaufenden Messung der mittleren absoluten Durchfulssmengen in uneröffneten Gefässen in situ.

Introduction of the Thermostromuhr, an instrument for measuring the velocity of the blood flow.

1904 CE

#843

Die unmittelbare Registrierung der Herztöne.

Frank obtained the first perfect pulse curves with special manometers, the so-called “Frank capsules”.

1897 CE

#5064

Die Wertbestimmung des Diphtherieheilserums.

Ehrlich improved Behring’s diphtheria antitoxin through quantitative titration and established an international standard for this and other antitoxins. This was the beginning of the concept of biological standar…

1952 CE

#1354.2

Different forms of signalling employed by the nervous system.

In 1970 Katz shared the Nobel Prize in Physiology or Medicine with Ulf von Euler and J. Axelrod "for their discoveries concerning the humoral transmitters in the nerve terminals and the mechanism for their storage, re…

1916 CE

#1904

Digitaliswirkung am isolierten Vorhof des Frosches.

An important analysis of the action of digitalis on the isolated heart.

1930 CE

#1920

Digoxin, a new digitalis glucoside.

Isolation of digoxin from Digitalis lanata.

1708 CE

#763

Disputatio medica inauguralis de circulo sanguinis in corde.

First description of the coronary valves and the venae thebesii.

1667 CE

#467.2

Disquisitio anatomica de formatu foetu.

Founding work of developmental chemical embryology, the first book to report chemical experiments on the developing mammalian embryo, and the first to give practical instructions on dissection of embryos. Needham was …

1738 CE

#11713

Dissertatio de structura et motu musculari.

This was the text of the first Croonian Lecture at the Royal Society. In it Stuart promoted a strictly hydraulic iatromechanism as a theory of muscular motion. This work was translated into English in 1739. Digital fa…

1673 CE

#469

Dissertatio epistolica de formatione pulli in ovo.

This and the De ovo incubato (No. 468) placed the study of embryology on a sound basis, surpassing in accuracy all other contemporary work on the subject and foreshadowing some of the more important general lines of r…

1817 CE

#474

Dissertatio sistens historiam metamorphoseos, quam ovum incubatum prioribus quinque diebus subit.

Pander’s doctoral thesis (unillustrated) in which he announced his discovery of the trilaminar structure of the chick blastoderm, a term that he coined. Pander's discovery stimulated von Baer’s research. A…

1743 CE

#765.1

Dissertationem inauguralem de vera nervi intercostalis origine.

Taube described the carotid body and named it “ganglion minutum”, See J. Pick, J. Hist. Med., 1959, 14, 61-73.

1512 CE

#571

Divini Gregorii Nyssae episcopi qui fuit frater Basilii Magni libri octo. I. De homine. II. De anima. III. De elementis. IIII. De viribus animae. V. De voltario etinuoltario. VI. De fato. VII. De libero arbitrio. VIII. De prouidentia.

Nemesius’ De natura hominis, a physiological and psychological study of man, was highly esteemed during the Middle Ages. Nemesius, who wrote in the 4th century CE, was one of the first to propose that mental pro…

1976 CE

#2660.28

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Discovery of the first “oncogene. In 1989 Varmus and Bishop shared the Nobel Prize for in Physiology or Medicine "for their discovery of the cellular origin of retroviral oncogenes."

1884 CE

#1572

Doctrines of the circulation.

1969 CE

#532.4

Early stages of fertilization in vitro of human oocytes.

First successful in-vitro fertilization of human oocytes. In 2010 Robert Edwards was awarded the Nobel Prize in Physiology or Medicine "for the development of in vitro fertilization."

1930 CE

#532.9

Early theories of sexual generation.

1870 CE

#492

Eierstock und Ei.

Waldeyer discovered the germinal epithelium.

1935 CE

#1949

Ein Beitrag zur Chemotherapie der bakteriellen Infektionen.

Introduction of Prontosil, the first drug containing sulfanilamide. In 1939 Domagk was awarded the Nobel Prize in Physiology or Medicine "for the discovery of the antibacterial effects of prontosil."

1899 CE

#1428

Einleitung in die vergleichende Gehirnphysiologie und vergleichende Psychologie.

1889 CE

#7996

Electrical stimulation of the heart in man.

MacWilliams described experiments in which application of an electrical impulse to the human heart in asystole caused a ventricular contraction, and that a heart rhythm of 60–70 beats per minute could be evoked …

1984 CE

#2068.21

Electricity and medicine: A history of their interaction.

1895 CE

#644

Elektrophysiologie.

First exhaustive treatise on electrophysiology. English translation, 2 vols., London, 1896-98.

1732 CE

#666.1

Elementa chemiae. 2 vols.

Boerhaave was the first to separate out urea from urine, and to do so without adding chemical substances such as alcohol or nitric acid. He first published his method for isolating it in the above work. English transl…

1757 CE–1766 CE

#588

Elementa physiologiae corporis humani. 8 vols.

Haller synthesized the whole physiological knowledge of his time. In the above, probably his greatest work, Haller included some anatomical descriptions which were most valuable. He is said to have written more than 1…

1667 CE

#577

Elementorum myologiae specimen.

In this work Stensen, in collaboration with the mathematician Vincenzio Viviani (1622-1703), a pupil of Galileo, developed a geometrical description of muscular contraction, and attempted to show theoretically that mu…

1669 CE

#3349

Elements of speech, an essay of inquiry into the natural production of letters; with an appendix concerning persons deaf and dumb.

Includes a section on the education of deaf-mutes. Paracusis is described in the Appendix, p. 166.

2008 CE

#8308

Embodiments of will: Anatomical and physiological theories of voluntary animal motion from Greek antiquity to the Latin Middle Ages, 400 B.C - A.D.1300.

1916 CE

#6124.1

Embryology, anatomy, and diseases of the umbilicus together with diseases of the urachus

Contains the first reference to what would become known as “Cullen’s sign”, discoloration of the skin about the umbilicus, as a sign of ruptured ectopic gestation. This work contains extraordinary il…

1998 CE

#13286

Embryonic stem cell lines derived from human blastocysts.

Thomson and collaborators first isolated embryonic stem cells from human blastocysts. Order of authorship in original publication: Thomson, Itskovitz-Eldor, Shapiro et al. Available online from science.sciencemag.org …

2002 CE

#7673

Embryos in wax: Models from the Ziegler studio.

1648 CE

#11609

Encheiridium anatomicum, et pathologicum, in quo naturali constitutione partium, recessus a naturali statu demonstatur.

In book III, chapter 8 Riolan discusses the heart and presents his views on the circulation of the blood. "Riolan's opinion of the blood movement seems to have arisen from his attempt to reconcile strict Galenic belie…

1996 CE

#14267

Enhancement of antitumor immunity by CTLA-4 blockade.

In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as …

1842 CE

#484

Entwickelungsgeschichte des Kaninchen-Eies.

Bischoff contributed important original work on the development of the rabbit.

1897 CE

#12198

Entwickelungslehre, Geburtshülfe und Gynäkologie in der hippokratischen Schriften.

Digital facsimile from the Internet Archive at this link.

1839 CE

#483

Entwicklungsgeschichte der Natter (Coluber natrix).

“Rathke’s pouch”, a diverticulum from the embryonic buccal cavity.

1861 CE

#487

Entwicklungsgeschichte des Menschen und der höheren Thiere.

First book on comparative embryology.

1952 CE

#6882

Entwicklungsgeschichte physiologischer Probleme in Tabellenform.

1892 CE

#509

Entwicklungsmechanische Studien. I. Der Werth der beiden ersten Furchungszellen in der Echinodermentwicklung. Experimentelle Erzeugen von Theil-und Doppelbildung. II. Ueber die Beziehungen des Lichtes zur ersten Etappe der thierischen Formbildung.

In the spring of 1891 Driesch succeeded in separating the blastomeres of the cleaving sea urchin egg. English translation in No. 534.3.

1965 CE

#14311

Enzymatic basis for the active transport of sodium and potassium across the cell membrane.

Skou discovered that the active transport of sodium and potassium is carried out in the cell membrane by an enzyme that serves as a sodium and potassium "pump," that catalyzes ATP hydrolysis. He named the enzyme "sodi…

1958 CE

#1931.6

Enzymatic O-methylation of epinephrine and other catechols.

The authors discovered the enzyme "COMT" or cathecol-O-methyltransferase, and determined that it was crucial in the methylation and inactivation of adrenergic and other catecholamine type neurotransmitters. (Thanks to…

1947 CE

#751.4

Enzymatic reactions in carbohydrate metabolism.

In 1947 Carl Cori and his wife Gerty Cori (1896-1957) shared the Nobel Prize (with Houssay) “for their discovery of the course of the catalytic conversion of glycogen.” They are more often remembered for t…

1956 CE

#752.4

Enzymic synthesis of deoxyribonucleic acid.

In 1959 Kornberg shared the Nobel Prize in Physiology or Medicine with Severo Ochoa "for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid." Order of authorshi…

1896 CE

#2710

Epistaxis répété chez un sujet porteur de petits angiomes cutanés et muqueux.

Rendu’s account of multiple hereditary telangiectasis (“Rendu–Osler–Weber disease”).

1671 CE

#294.1

Esperienze intorno a diverse cose naturali…

Includes the first scientific study of an electric fish. While the torpedo’s peculiar properties had provoked scientific speculation since at least the time of Aristotle, Redi was the first to perform an actual …

1936 CE

#4905

Essai d’un traitement chirurgical de certaines psychoses.

Prefrontal leucotomy (lobotomy). Translation in J. Neurosurg., 1964, 21, 1110-14. See also Egas Moniz's book Tentatives opératoires dans le traitement de certaines psychoses, Paris, 1936. His name was originall…

1861 CE

#7608

Essays and observations on natural history, anatomy, physiology, psychology, and geology by John Hunter, F.R.S. Being his posthumous papers on those subjects, arranged and revised, with notes; to which are added the introductory lectures on the Hunterian collection of fossil remains delivered in the theatre of the Royal College of Surgeons of England, March 8th, 10th and 12th, 1855 by Richard Owen .... 2 vols.

Digital facsimiles from the Hathi Trust at this link.