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Historical Bibliography Updated: July 7, 2024

Enzymatic O-methylation of epinephrine and other catechols.

Publication Details

J. Bio. Chem., 233, 400-401. 1958 CE.

The authors discovered the enzyme "COMT" or cathecol-O-methyltransferase, and determined that it was crucial in the methylation and inactivation of adrenergic and other catecholamine type neurotransmitters.

(Thanks to Juan Weiss for this reference and its interpretation.)

In 1970 Axelrod shared the Nobel Prize in Physiology or Medicine with Bernard Katz and Ulf von Euler "for their discoveries concerning the humoral transmitters in the nerve terminals and the mechanism for their storage, release and inactivation."

Catalog MetadataReference Information
Entry Number#1931.6
Permanent Linkhttps://staging.historyofmedicine.com/entry/2761
Author Bio LinkWikipedia ↗
External URLnoradrenaline-fate-and-control-of-its-biosynthesis