Facets

1971 CE

#534.4

Les sciences de la vie dans la pensée française du XVIIIe siècle. Genération des animaux de Descartes à l’Encyclopédie. 2e ed.

Translated into English by Robert Ellrich as The life sciences in eighteenth-century French thought, edited by Keith R. Benson, Stanford: Stanford University Press, 1998.

1783 CE

#12037

Lettera dell' Abate Spallanzani al Sig. Marchese Lucchesini.

Records on pp. 80-104 Spallanzani's work on the torpedo. In the 1780's Spallanzani turned to marine biology, making several trips to the Mediterranean region. On his visit to Portovenere in 1783 "he instituted the fir…

1966 CE

#534.1

Marcello Malpighi and the evolution of embryology. 5 vols.

Vol. 1 is an exhaustive biography of Malpighi; the remaining 4 volumes provide an extensive account of the development of embryology, and annotated English translations of Nos. 468 & 469.

1920 CE

#529

Mechanismus und Physiologie der Geschlechtsbestimmung.

Translated into English William J. Dakin as The Mechanism and Physiology of Sex Determination (London: Methuen & Co., 1923). Digital facsimile of the 1920 edition from Google Books at this link. Digital facsimile of t…

1984 CE

#14263

Molecular analysis of the period locus in Drosophila malanogaster and identification of a transcript involved in biological rhythms.

Rosbach and colleagues, including Jeffrey C. Hall, sequenced the Drosophila period gene in 1984. Full text available from cell.com at this link. Order of authorship in the original publication: Reddy, Zehring, Wheeler…

1953 CE

#256.3

Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid.

Watson and Crick shared the Nobel Prize with M. H. F. Wilkins (No. 256.4) "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material." L…

1997 CE

#8749

Moving questions: A history of membrane transport and bioenergetics.

"This book describes half a century of progress in two mainstream areas of biological research: membrane transport, initially a focus of physiologists, and oxidative phosphorylation, initially a focus of biochemists. …

1877 CE–1880 CE

#632

Observations on the locomotor system of Medusae. 3 pts.

Charles Sherrington described the significance of Romanes' research on jellyfish in terms of its impact on cardiac physiology: "Romanes's observations carried out with simple means were novel and fundamental. The ques…

1773 CE

#589

Of the electric property of the torpedo.

The first accurate study of the electrical organs of the torpedo fish were made by Walsh, who was given the Copley Medal of the Royal Society for his work on the subject. Walsh proved that the shock of the torpedo was…

1866 CE–1868 CE

#336

On the anatomy and physiology of the vertebrates. 3 vols.

Vol. 1. Fishes and reptiles; Vol. 2. Birds; Vol. 3. Mammals. The most important work on the subject after Cuvier, based entirely on personal observations. Owen entitled his 40th and concluding chapter "Derivative hypo…

1832 CE

#12197

On the influence of physical agents on life, by W. F. Edwards. Translated from the French by Dr. Hodgkin and Dr. Fisher. To which are added, in the appendix, some observations on electricity by Dr. Edwards, M. Pouillet, and Luke Howard; on absorption, and the uses of the spleen, by Dr. Hodgkin; on the microscopic characters of the animal tissues and fluids, by J. J. Lister and Dr. Hodgkin, and some notes to the work of Dr. Edwards.

Digital facsimile from Google Books at this link.

1896 CE

#13072

On the pigment of the negro's skin and hair.

"In the present state of our knowledge we can only say that it seems highly probable that the pigment of the negro's hair is not different from the dark pigment found in the hair of the white races, and we may infer t…

1993 CE

#14301

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.

The authors cloned and generated the sequence of the lin-14 gene. They discovered that a segment in lin-14 mRNA (messenger RNA), was necessary for its inhibition by lin-4. Ruvkun and Ambros (No. 14010) then compared r…

1998 CE

#13957

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

The authors reported that tiny snippets of double-stranded RNA (dsRNA) effectively shut down specific genes, driving the destruction of messenger RNA (mRNA) with sequences matching the dsRNA. As a result, the mRNA can…

1977 CE

#14143

Resolution of some components of adenylate cyclase necessary for catalytic activity.

Goodman shared the 1994 Nobel Prize in Physiology or Medicine with Martin Rodbell "for their discovery of G-proteins and the role of these proteins in signal transduction in cells." In this paper Goodman and Ross show…

1984 CE

#14265

Restoration of circadian behavioral rhythms by gene transfer in Drosophila.

"At The Rockefeller University in the early 1980s, Young and his two lab members, Ted Bargiello and Rob Jackson, further investigated the circadian period gene in Drosophila. They constructed segments of recombinant D…

1970 CE

#2660.23

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…

1942 CE

#532

Some aspects of early human development.

Report of the youngest normal implanted fertilized human ovum, fertilization age about 7 1/2 days. Hertig and Rock published a more detailed study in Contr. Embryol. Carneg. Instn. 1945, 31, 65-84.

1971 CE

#6890

Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae.

Nathans showed that the restriction enzyme discovered by Hamilton Smith cleaved SV40 DNA into 11 specific pieces. Nathans and his student Kathleen Danna wrote: "The availability of pieces of SV40 DNA from specific sit…

1977 CE

#11044

Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significa…

1965 CE

#257.2

Structure of a ribonucleic acid.

The complete sequence of an alanine transfer RNA determined – the first nucleic acid structure to be determined. With seven co-authors. In 1968 Holley shared the Nobel Prize in Physiology or Medicine with Har Go…

1958 CE

#752.6

Studies on polynucleotides. I. A new and general method for the chemical synthesis of the C5'-C3' intemucleotide linkage. Synthesis of deoxyribo-dinucleotides.

In 1968 Khorana shared the Nobel Prize in Physiology or Medicine with R. W. Holley and M. W. Nirenberg "for their interpretation of the genetic code and its function in protein synthesis." H. G. Khorana, T. M. Jacob, …

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1902 CE

#518

The accessory chromosome; sex determination.

McClung showed that the accessory chromosomes are the determinants of sex.

1993 CE

#14010

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA sil…

1896 CE

#238

The cell in development and inheritance.

Wilson emphasized the function of cytology in the study of embryology, heredity, evolution and general physiology. The above work has been called the single most influential treatise on cytology of the 20th century. T…

2014 CE

#7289

The complete genome sequence of a Neanderthal from the Altai Mountains.

First complete sequence of a Neanderthal genome. With more than 20 co-authors. In 2022 Pääbo was awarded the Nobel Prize in Physiology or Medicine "for his discoveries concerning the genomes of extinct homin…

1835 CE–1859 CE

#603

The cyclopaedia of anatomy and physiology. Edited by Robert Bentley Todd. 5 vols.

Contributors included Richard Owen and Thomas Huxley, and physicians James Paget, James Young Simpson, and William Bowman.The discoveries of Purkynĕ and Valentin, together with additional observations by William Sharp…

1878 CE

#499

The embryology of Clepsine.

The study of cell-lineage was initiated by Whitman’s paper on Clepsine.

1974 CE

#9941

The genetics of CAENORHABDITIS ELEGANS.

In 2002 Brenner shared the Nobel Prize in Physiology or Medicine in Physiology or Medicine with H. Robert Horvitz and John Sulston "for their discoveries concerning genetic regulation of organ development and programm…

1920 CE

#7000

The growth and shedding of the antlers of the deer. The histological phenomena and their relation to the growth of bone.

The first study of the unusual and dramatic physiology of the annual growth and shedding of the antlers of deer. "The amount of bony matter annually secreted to form antlers of the larger deer is enormous, antlers of …

1929 CE

#566.1

The growth, development and phosphatase activity of embryonic avian femora in limb-buds cultivated in vitro.

First modern organ cultures.

1966 CE

#1588.3

The history of cell respiration and cytochrome

See No. 968.

1980 CE

#14256

The identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.

See also: Novick, P., Ferro, S. and Schekman, R. "Order of events in the yeast secretory pathway," Cell, 25, 1981, 461-469. In 1979 Schekman devised a genetic selection for temperature-conditional secretion-defective …

1913 CE

#527.1

The mechanism of fertilization.

2011 CE

#6843

The shocking history of electric fishes: From ancient epochs to the birth of modern neurophysiology.

The first comprehensive history of this subject.

1908 CE–1952 CE

#18

The works of Aristotle translated into English. Edited by J.A. Smith and W.D. Ross. 12 vols.

De motu animalium. De incessu animalium. In his Works, edited by J.A. Smith and W.D. Ross, 5, 698a-714b., Oxford, 1912. De Anima. In his Works… translated into English. Edited by J. A. Smith and W. D. Ross. 3, …

1745 CE

#308

Traité d’insectologie.

This pioneering work on experimental entomology incorporates Bonnet’s most important discovery–parthenogenetic reproduction–based on his study of aphids. Bonnet used the result of this and other disc…

1975 CE

#14249

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. II. Reconstitution of functional rough microsomes from heterologous components.

"In 1975 Günther Blobel showed that in certain cases amino acids in a protein serve as an address label that determines where a protein is to be delivered. Amino acid sequences determine whether a protein is to b…

1980 CE

#14255

Transport of vesicular stomatitis virus glycoprotein in a cell-free extract.

See also: Fries & Rothman, "Transitent activity of Golgi-like membranes as donors of vescular stomatitis viral glycoprotein in vitro," J. Cell. Biol., 90, 1981, 697-704. "Rothman's research[15] details how vesicles&md…

1891 CE

#517.1

Untersuchungen über den ersten Entwicklungsvorgänge in den Eiern der Insekten. II. Ueber Spermatogenese und deren Beziehung zur Eientwicklung bei Pyrrhocoris apterus.

In his study of the testicles of the firebug (Pyrrhocoris) Henking noticed that one chromosome did not take part in meiosis. He named this X element because its strange behavior made him unsure whether it was genuinel…

1997 CE

#7457

Viable offspring derived from fetal and adult mammalian cells.

Cloning of the lamb Dolly, the first mammal to be cloned from an adult cell. Her birth established that the nuclei of at least some adult cells can be used to produce sheep or other animals that are genetically identi…

1970 CE

#2660.22

Viral RNA-dependent DNA polymerase: RNA-dependent DNA polymerase in virions of RNA tumour viruses.

In 1970 Baltimore and Temin discovered that certain viruses that have their genes in the form of RNA can copy the RNA "backward" into DNA in infected cells. The enyzme, reverse transcriptase, enables the manufacture o…

1882 CE–1883 CE

#702

Zur Chemie des Zellkerns.

Among the many important contributions of Kossel was his study of the chemistry of the cell and cell-nucleus. Kossel correctly concluded that the function of nuclein is neither to act as a storage substance nor to fur…