Facets

1887 CE

#12295

Sphygmographische Untersuchungen an Geisteskranken.

Ziehen, a student of Hermann Munk, wrote his habiltation thesis on sphygmographic studies of psychiatric patients. This was the first monograph on the subject.

1977 CE

#11044

Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significa…

1861 CE

#14188

Stammering and stuttering, their nature and treatment.

1939 CE

#800

STANDARDIZATION of methods of measuring the arterial blood pressure. A joint report of the committees appointed by the Cardiac Society of Great Britain and Ireland and the American Heart Association.

Digital facsimile from PubMedCentral at this link.

1965 CE

#12283

Starling on the heart. Facsimile reprints, including the Linacre lecture on the law of the heart. Analysis and critical comment by Carleton B. Chapman and Jere H. Mitchell.

1944 CE

#1935

Streptomycin, a substance exhibiting antibiotic activity against Grampositive and Gram-negative bacteria.

Introduction of streptomycin. Order of authorship: Schatz, Gregory, Waksman. In 1952 Waksman was awarded the Nobel Prize in Physiology or Medicine "for ingenious, systematic, and successful studies of the soil microbe…

2018 CE

#14352

Structure and distribution of an unrecognized interstitium in human tissues.

The authors described "the anatomy and histology of a previously unrecognized, though widespread, macroscopic, fluid-filled space within and between tissues, a novel expansion and specification of the concept of the h…

1965 CE

#257.2

Structure of a ribonucleic acid.

The complete sequence of an alanine transfer RNA determined – the first nucleic acid structure to be determined. With seven co-authors. In 1968 Holley shared the Nobel Prize in Physiology or Medicine with Har Go…

1971 CE

#14231

Structure of the porcine LH-and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses.

Publication in May 1971: Working with pig preparations, the authors reinvestigated the peptide that they had previously isolated, which acted as an LH-FSH releasing hormone. They performed an Edman-dansyl degradation …

1932 CE

#12278

Studies in the metabolism of sodium r-lactate. 1. Response of normal human subjects to the intravenous injection of sodium r-lactate. 2. Response of human subjects with acidosis to the intravenous injection of sodium r-lactate. 3. Reponse of human subjects with liver damage, disturbed mineral and water balance, and renal insufficiency to the intravenous injection ofsodium r-lactate.

Hartman added sodium lactate to the standard Ringer's solution to form Ringer's lactate solution, also known as Hartmann's solution.

1926 CE–1927 CE

#796

Studies in the velocity of blood flow.

First practical method of measuring circulation time. "In 1925, Hermann Blumgart performed the first diagnostic procedure using radioactive indicators on humans; this first is well recognized. Less well recognized is …

1952 CE

#3108.2

Studies on condensed pyrimidine system. IX. The synthesis of some 6-substituted purines.

Synthesis of 6-mercaptopurine. In 1988 Gertrude Elion shared the Nobel Prize in Physiology or Medicine with George Hitchings and Sir James Black “for their discoveries of important principles for drug treatment.…

1934 CE

#2719

Studies on experimental hypertension. 1. The production of persistent elevation of systolic blood pressure by means of renal ischemia.

Goldblatt discovered the role of the kidneys in the regulation of blood pressure. This was the first of Goldblatt’s papers on experimental hypertension, which established an aetiologic role for renal ischemia in…

1958 CE

#752.6

Studies on polynucleotides. I. A new and general method for the chemical synthesis of the C5'-C3' intemucleotide linkage. Synthesis of deoxyribo-dinucleotides.

In 1968 Khorana shared the Nobel Prize in Physiology or Medicine with R. W. Holley and M. W. Nirenberg "for their interpretation of the genetic code and its function in protein synthesis." H. G. Khorana, T. M. Jacob, …

1941 CE

#4276

Studies on prostatic cancer. I. The effect of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate.

In 1966 Huggins was awarded the Nobel Prize for Physiology or Medicine for discovering in 1941 "for his discoveries concerning hormonal treatment of prostatic cancer."

1927 CE

#9335

Studies on the velocity of blood flow: I. The method utilized.

Reports the first diagnostic procedure, done in 1925, using radioactive indicators on humans. "Less well recognized is the fact that Blumgart and his coworker Otto C. Yens, then a medical student, developed the first …

1956 CE

#4257

Successful homotransplantation of the human kidney between identical twins.

This was the first successful kidney transplant. The patient, both of whose own kidneys had been removed, was alive 11 months after the transplant. With Warren R. Guild. See No. 4256.1. In 1990 Joseph Murray shared th…

1886 CE

#1416

Sulla fina anatomia degli organi centrali del sistema nervoso.

Golgi’s histological studies made a clear conception of the nervous system possible for the first time. He demonstrated the existence of multipolar nerve-cells (Golgi cells) by means of his silver nitrate stain,…

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1879 CE

#782.1

Sur la contractilité capillaires sanguins.

Rouget made an important investigation of the control of capillary circulation. He described cells (“Rouget’s cells”) on the outer surfaces of capillary walls, considered to be contractile. English t…

1758 CE

#469.2

Sur la formation du coeur dans le poulet…2 vols.

Haller devised a numerical method to demonstrate the rate of growth of the fetus, showing that the rate of growth is relatively rapid in the earlier stages but that the tempo gradually decreases. He calculated the rat…

1860 CE

#777

Sur la pression du sang dans le système artériel.

1843 CE

#608

Sur le courant électrique des muscles des animaux vivants ou récemment tués.

Matteucci’s “rheoscopic frog” effect.

1838 CE

#605

Sur le courant électrique ou propre de la grenouille.

Matteucci established the difference of potential between injured nerve and its muscle.

1854 CE

#1326

Sur les résultats de la section et de la galvanisation du nerf grand sympathique au cou.

1825 CE

#476

Symbolae ad ovi ovium historiam ante incubationem.

First description of the germinal vesicle in the embryo, “Purkynĕ’s vesicle” This is located on the spot of the yolk where the embryo develops. Later identified with the cell nucleus, this formed a b…

1907 CE

#1895.1

Synthese des Imidazolyläthylamins.

Synthesis of histamine.

1987 CE

#13940

Targeted correction of a mutant HPRT gene in mouse embryonic stem cells.

Smithies discovered, simultaneously with Mario Capecchi and Martin Evans, the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previ…

1781 CE

#13253

Tentamen resolvendi problema ab Academia Scientiarum Imperial Petropoitana ad annum 1780 public propositum. 1) Qualis fit natura et character sonorum litterarum vocalium a, e, i, o, u tam insigniter inter se diversorum. 2) Annon construi qutans instrumenta ordini tuiborum organicorum, sub termino vocis humane noto, similia, quae literarum vaclium a, e, i, o, u sonos exprimant.

In the first part of this work Kratzenstein described how the vowels could be produced in the vocal tract. In the second part he described the construction of a new kind of organ with pipes for each of the vowels. Eac…

1912 CE

#527

Terminologie der Entwicklungsmechanik.

1898 CE–1900 CE

#649

Text-book of physiology. Edited by Edward Schäfer. 2 vols.

A collective work and a classic textbook of physiology, edited by Schäfer using the original version of his last name. He was a pupil of Sharpey, and when that great man died without any known descendants Sch&aum…

1899 CE–1904 CE

#1293.1

Textura del sistema nervioso del hombre y de los vertebrados. 2 vols. in 3.

From publication in fascicules, 1897-1904 (vol. 1 in 3 pts., vol. 2 in 4 pts.) This monumental work set out the cytological and histological foundations of modern neurology. Ramón y Cajal’s research confi…

1902 CE

#518

The accessory chromosome; sex determination.

McClung showed that the accessory chromosomes are the determinants of sex.

1925 CE

#1912

The action and uses in medicine of digitalis and its allies.

c. 1914 CE

#1340

The action of certain esters and ethers of choline, and their relation to muscarine.

Demonstration of the inhibitory action of acetylcholine on the heart. In 1936 Dale shared the Nobel Prize in Physiology or Medicine with Otto Loewi (No. 1343) "for their studies in the chemical mediation of nervous im…

1927 CE

#1528

The action of light on the eye.

On the electrical discharges from the vertebrate optic nerve.

1922 CE

#793

The anatomy and physiology of the capillaries.

Silliman Lectures. Krogh was first to describe the adaptation of blood perfusion in muscle and other organs according to demands through opening and closing the arterioles and capillaries. In 1920 Krogh received the N…

1928 CE

#1308

The basis of sensation. The action of the sense organs.

In 1932 Adrian shared the Nobel Prize in Physiology or Medicine with Charles Scott Sherrington "for their discoveries about the function of neurons." See also Nos. 1307, 1528, and 1303.

1950 CE

#8779

The biology of human starvation. 2 vols.

"To gain insight into the physiology of starvation, in 1944 [Ancel] Keys carried out a starvation study with 36 conscientious objectors as test subjects in the Minnesota Starvation Experiment. At the time, conscientio…

1936 CE

#2720

The blood cyanates in the treatment of hypertension.

Barker made thiocyanate treatment a practical proposition in hypertension.

1912 CE

#791

The blood pressure fall produced by traction on the carotid artery.

First description of the carotid sinus depressor reflex.

1921 CE

#855

The blood supply to the heart.

Coronary arterial anatomy studied by radiography of the injected arteries by a standard technique.

1911 CE–1912 CE

#790

The blood-vessels in the arterioles, capillaries and small veins of the human skin.

Lombard soaked the skin in cedarwood oil, rendering transparent the superficial epidermal layers, and thus making possible many direct observations on it.

1927 CE

#797

The blood-vessels of the human skin and their responses.

1985 CE

#1588.21

The brain machine: The development of neurophysiological thought.

Translation of Le cerveau-machine: physiologie de la volonté, Paris, 1983.

1993 CE

#14010

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA sil…

1926 CE

#795.1

The capillary pressure in frog mesentery as determined by micro-injection methods.

Direct measurement of the blood pressure within the capillaries.

1997 CE

#14274

The capsaicin receptor: a heat-activated ion channel in the pain pathway.

"Abstract: Capsaicin, the main pungent ingredient in ‘hot’ chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the…

1932 CE

#2861

The cardiac output of man in health and disease.

1896 CE

#238

The cell in development and inheritance.

Wilson emphasized the function of cytology in the study of embryology, heredity, evolution and general physiology. The above work has been called the single most influential treatise on cytology of the 20th century. T…