Facets

1955 CE

#3978.1

Ein neues antidiabetisches Prinzip. Ergebnisse klinischer Untersuchungen.

Introduction of carbutamide (BZ55), the first of the sulphonylureas. It was followed by tolbutamide and chlorpropamide.

1903 CE

#2436.2

Eine Lepraähnliche Erkrankung der Haut und der Lymphdrtüsen bei Wanderratten.

Murine leprosy described.

1909 CE

#3895

Eine neue Methode der endonasalen operation von Hypophysentumoren.

Hirsch first demonstrated the transnasal transseptal exposure of the sphenoid sinus and pituitary gland in a cadaveric specimen in front of the medical society of Vienna.

1878 CE

#6070

Eine neue Methode der Exstirpation des ganzen Uterus.

Freund performed the first successful abdominal hysterectomy for cancer. Although removal of the uterus by the abdominal route had been carried out earlier, to Freund belongs the credit for the invention of the operat…

1893 CE

#3508

Eine neue Methode der Gastrostomie bei Carcinoma oesophagi.

See No. 3512.

1896 CE

#2549

Eine neue Methode zur raschen Erkennung des Choleravibrio und des Typhusbacillus.

The discovery of bacterial agglutination. Gruber and Durham discovered the agglutinating action of the serum of typhoid patients upon the typhoid bacillus. First briefly reported by Durham: On a special action of seru…

1896 CE

#1178.1

Einige Versuche über Ovarientransplantation bei Kaninchen.

Knauer implanted ovaries into immature or castrated animals, producing development of sexual characteristics, thus demonstrating the existence of an ovarian hormone.

1937 CE

#12832

Electrophoresis of serum globulin. II- Electrophoretic analysis of normal and immune sera.

Tiselius showed that an antibody that he produced in a rabbit by immunizing it with albumin (ovalbumin) was clearly located in the gamma globulin fraction. He summarized the paper with this statement: "Investigation o…

1844 CE–1859 CE

#5597

Elémens de pathologie chirurgicale. 5 vols.

Nélaton was a great teacher and operator at the Hôpital St. Louis. He invented several surgical instruments. The description of “Nélaton’s tumor” of bone appears in vol.. 2, p. 46…

2005 CE

#10232

Emblematic monsters: Unnatural conceptions and deformed births in early modern Europe.

1941 CE

#4153

En ny og spesifikk kutan-reaksjon ved Boecks sarcoid. En foreløbig meddelelse.

Kveim’s test for sarcoidosis.

1922 CE–1924 CE

#3798

Endocrinology and metabolism presented in their scientific and practical clinical aspects by ninety-eight contributors. 5 vols.

1988 CE

#3911.2

Endocrinology: people and ideas.

Thematic historical essays written by pioneers in the field, edited by McCann.

1917 CE

#3194

Endothelioma of the right bronchus removed by peroral bronchoscopy.

First reported case.

1996 CE

#14267

Enhancement of antitumor immunity by CTLA-4 blockade.

In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as …

1820 CE

#9072

Ensaio dermosographico ou Succinta e systematica descripção das doenças cutaneas, conforme os principios e observações dos doutores Willan, e Bateman, com indicacão dos respectivos remedios aconselhados por estes celebres authores, e alguns outros.

The first book on dermatology published in Portuguese. Digital facsimile from the Internet Archive at this link.

1931 CE

#5227.1

Entwurf einer Geschichte der ansteckenden Geschlechtskrankheiten.

1967 CE

#14198

Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis.

Jay Seegmiller and his colleagues at NIH discovered that the rare genetic disease, Lesch–Nyhan syndrome, was due to a profound deficiency of an enzyme known as hypoxanthine guanine phosphoribosyltransferase, or …

1971 CE

#12601

Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.

Perlmann (principal investigator) and Engvall conceptualized and developed the very commonly used enzyme-lined immunosorbent assay (ELISA) that uses antibodies to detect proteins and other different immunogens. The as…

1940 CE

#5398.1

Epidemic and endemic typhus. Protective value for guinea pigs of vaccines prepared from infected tissues of the developing chick embryo.

Typhus vaccine.

1919 CE–1920 CE

#3850

Epinephrin hypersensitiveness test in the diagnosis of hyperthyroidism.

Goetsch devised a skin reaction test for use in the diagnosis of hyperthyroidism

1912 CE

#2639

Epithelial proliferation induced by the injection of gasworks tar.

Experimental production of cancer by the injection of tar as a byproduct of the manufacture of coal gas.

1889 CE

#2621

Erfolgreiche experimentelle Uebertragung von Carcinom.

Hanau successfully transplanted cancer in mammals.

1907 CE

#3892

Erfolgreiche Operation eines hypophysen Tumors auf nasalem Wege.

Schloffer’s Operation by the nasal route.

1887 CE

#3296

Erste Heilung eines Larynx-Cancroids vermittelst Ausrottung per vias naturales.

First successful intralaryngeal extirpation of a malignant growth.

1873 CE

#4064

Erythema serpens.

First description of erythema serpens, usually called “erysipeloid of Rosenbach”, following the latter’s paper in Arch. klin. Chir., 1887, 36, 346.

1925 CE

#4150.1

Erythro- et keratodermia variabilis in a mother and daughter.

“Mendes Da Costa’s syndrome” – erythrokeratoderma variabilis.

1911 CE

#4146

Érythroplasia du gland.

Erythroplasia of Queyrat, a condition similar to the precancerous dermatosis described by Bowen (No. 4148).

1924 CE

#2343

Essai d’immunisation contre l’infection tuberculeuse.

B.C.G. (Bacille Calmette–Guérin) vaccine was first produced in 1906 and subcultured for 13 years. It was first used as a prophylactic against tuberculosis in children in 1921. It remains in use. See also …

1926 CE

#5289

Essai de prophylaxie des trypanosomiases par des dérivés phénylarsiniques administré

First attempt to induce prophylaxis by chemical means in trypanosomiasis. With S. Nicolau and I. Galloway.

1792 CE

#3810

Essai sur le goitre et le crétinage. Où l'on recherche particulièrement quelles son les causes de ces deux maladies des habitans des vallées, et quels sont les moyens physiques et moraux qu'il convient d'employer pour s'en préserver entièrement à l'avenir.

Fodéré considered cretinism to be due to the concentrated air in deep valleys, rather than to water. He also drew attention to the skeletal changes. Digital facsimile from Google Books at this link.

1909 CE

#3530

Essais de traitement de quelques cas d’épithélioma de l’oesophage par les applications locales directes de radium.

Radium therapy by means of the esophagoscope.

1917 CE

#4149

Étude sur le lupus pernio et ses rapports avec les sarcoïdes et la tuberculose.

“Besnier–Boeck–Schaumann disease” (see also Nos. 4095, 4128). Through Schaumann’s paper the systemic nature of sarcoidosis came to be recognized.

1894 CE

#4117

Étude sur le parasite du “pied de Madura”.

Isolation of Streptothrix (Actinomyces) madurae.

1922 CE–1923 CE

#1164

Evaluation of the hormone of the infundibulum of the pituitary gland in terms of histamine, with experiments on the action of repeated injections of the hormone on the blood pressure.

1962 CE

#1138.2

Evidence for calcitonin – a new hormone from the parathyroid that lowers blood calcium.

With E. C. Cameron, B. A. Cheney, A. G. F. Davidson, and K. G. Henze.

1983 CE

#14212

Evidence for plasmid mediated toxin production in Bacillus anthracis.

The authors illustrated and proved that “heating V770-NPI-R containing anthrax strains, to exactly 42.5 degrees centigrade, as Pasteur and colleagues reported in GM 14211, essentially ‘cured’ these s…

1976 CE

#14245

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

Discovery of V(D)J recombination, the genetic mechanism which produces antibody diversity. In 1987 Tonegawa was awarded the Nobel Prize in Physiology or Medicine "for his discovery of the genetic principle for generat…

1963 CE

#2660.14

Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects.

1730 CE

#10109

Exanthematologia ; or, an attempt to give a rational account of eruptive fevers, especially of the measles and small pox, In two parts. Parts I Of the blood, the air, venoms, Infection: fever of all kinds in general with their varieties, descriptions, names & C but more professedly and fully of the measles ... Part II Of the small pox ... To which is added. An appendix concerning inoculation.

Includes the first clear account of chicken pox as a distinct disease, and the first distinction between the spots made by flea bites from those seen in eruptive fevers.

1992 CE

#9928

Excerpts from classics in Allergy. Second edition.

1874 CE

#3824

Excision of the thyroid gland.

Watson was a pioneer of thyroidectomy in the treatment of goitre, although Green (No. 3814) was the first to perform the operation. Also in Brit. med. J., 1875, 2, 386-88.

1850 CE

#3817

Existence de l’iode dans les plantes d’eau douce. Conséquences de ce fait pour la géognosie, la physiologie végétale, la thérapeutique et peut-être pour l’industrie.

Chatin was the first to show that iodine could prevent endemic goitre and cretinism.

1840 CE

#3816

Exophthalmos durch Hypertrophie des Zellgewebes in der Augenhöhle.

In Europe, outside the British Isles, exophthalmic goitre, or Graves’s disease, is known as “Basedow’s disease”. His accurate description of four cases in which he described exophthalmos, goitr…

1889 CE

#1177

Expérience démontrant la puissance dynamogénique chez l’homme d’un liquide extrait de testicules d’animaux.

Brown-Séquard injected into himself a testicular extract in order to bring about rejuvenation. He reported much benefit but his advocacy of this method evoked scepticism and criticism, although it stimulated re…

1953 CE

#3908.1

Experience with hypophysectomy in man.

Demonstration of the beneficial effect of hypophysectomy in cancer of the breast and of the testis.

1931 CE

#11188

Experiences with the cerebellar astrocytomas. A critical review of seventy-six cases.

Cushing's most extensive contribution to pediatric neurosurgery concerned his operative experience with these tumors (often benign) that most frequently occur in childhood.

1683 CE

#3927

Experimenta nova circa pancreas.

Brunner came near to discovering pancreatic diabetes. His experiments on the dog represent pioneer work on internal secretion. Following excision of the pancreas, he recorded extreme thirst and polyuria. Translated in…

1936 CE

#3905

Experimental diabetes insipidus in the monkey.

With C. Fisher and S. W. Ransom.

1939 CE

#3907

Experimental diabetes insipidus.

Production of diabetes insipidus in dogs by injury to the hypothalamus.