Facets

1921 CE–1922 CE

#1205

The internal secretion of the pancreas.

This paper reports the isolation of insulin. An extract from the pancreas of a dog, removed after ligation of the excretory duct, was found to exercise a reducing influence on the percentage of sugar in the blood. Dig…

1922 CE

#3966

The internal secretion of the pancreas. (Abstract).

A preliminary one-page communication regarding the isolation of insulin, made to a meeting of the American Physiological Society in December 1921. Digital facsimile from insulin.library.utoronto.ca at this link. In 19…

1903 CE–1907 CE

#3793

The internal secretions and the principles of medicine. 2 vols.

Sajous, pioneer American endocrinologist, wrote the first treatise on the subject. In this work he regarded the adrenal, pituitary, and thyroid glands as controlling the immunizing mechanism of the body.

1915 CE

#1133

The isolation in crystalline form of the compound containing iodine, which occurs in the thyroid; its chemical nature and physiologic activity.

Kendall isolated in crystalline form the thyroid hormone “thyroxine” on Christmas Day, 1914.

1936 CE

#1202

The isolation of the principal estrogenic substance of liquor folliculi.

Isolation of oestradiol. With S. A. Thayer and E. A. Doisy.

1929 CE

#1189

The male hormone.

Funk and Harrow obtained crude active male hormone extracts from male urine.

1963 CE

#6495.8

The medical writings of Moses Maimonides. Treatise on asthma.

1925 CE

#2649

The melanomata, their morphology and histogenesis. A study of cell origins and transformations, with a critical discussion on aspects of tumour growth, and a clinical review.

The first exhaustive monograph on the pathology of melanoma. Also issued as a separate monograph (Edinburgh: Oliver & Boyd, 1925).

1927 CE

#1185

The menstrual cycle of the monkey, Macacus rhesus. Observations on normal animals, the effects of removal of the ovaries and the effects of injection of ovarian and placental extracts into the spayed animals.

This paper marks the beginning of modern knowledge of the menstrual cycle. Allen showed that uterine bleeding occurs as a withdrawal effect when estrogen ceases to act on the endometrium.

1925 CE

#2648

The microscopical examination of filterable viruses associated with malignant new growths.

Barnard supported, with photomicrographs, Gye’s theory concerning the origin of cancer.

1877 CE–1878 CE

#4073

The minute anatomy of dysidrosis.

1915 CE

#2641

The mortality from cancer throughout the world.

1931 CE

#7880

The mystery and lore of monsters. With account of some giants, dwarfs and prodigies.

Digital facsimile of the New York 1931 issue from the Hathi Trust at this link.

1846 CE

#2612.1

The nature and treatment of cancer.

The earliest account of the recognition of fragments of malignant tissue. Digital facsimile from Google Books at this link.

1926 CE

#3201

The nature of the “oat-celled sarcoma” of the mediastinum.

An important study of the histology of “oat-celled sarcoma” which Barnard showed to be primary carcinoma of the lung.

1999 CE

#10229

The Nazi war on cancer.

1938 CE

#3799

The oestrogenic activity of certain synthetic compounds.

Introduction of stilboestrol, the first synthetic estrogen. With L. Gol[d]berg, W. Lawson,

1923 CE

#3969

The original method as used for the isolation of insulin in semipure form for the treatment of the first clinical cases.

Collip improved insulin.

1930 CE

#1192

The ovary-stimulating hormone of the placenta.

Collip’s anterior-pituitary-like (A-L-P) factor.

1914 CE

#3847

The pathogenesis of experimentally produced goitre.

2014 CE

#10629

The Pelvis: Structure, gender and society.

"This book offers a critical review of the pelvic sciences—past, present and future—from an anatomical and physiological perspective....The book starts with a “construction plan” of the pelvis …

1931 CE

#5087.1

The phases of Haemophilus pertussis.

Leslie and Gardner classified H. pertussis cultures into four types and established an experimental basis for the development of an effective vaccine.

1895 CE

#1143

The physiological effects of extracts of the suprarenal capsules.

These workers demonstrated the existence of a pressor substance (adrenaline) in the adrenal medulla. Preliminary communications regarding the above appeared in the proceedings of the Physiological Society, J. Physiol.…

1936 CE–1939 CE

#1172

The physiology and pharmacology of the pituitary body. 2 vols.

Includes an extensive bibliography.

1910 CE

#2600

The physiology of the immediate reaction of anaphylaxis in the guinea-pig.

First adequate account of the physiological reactions leading to fatal anaphylactic shock.

1912 CE

#3896

The pituitary body and its disorders.

The first clinical monograph on the hypophysis. Cushing, outstanding neurological surgeon of the early 20th century, added much to our knowledge of the pituitary body and its disorders. The above work includes a descr…

1909 CE

#6215

The pituitary body and the therapeutic value of the infundibular extract in shock, uterine atony, and intestinal paresis.

1929 CE

#1149

The preparation of an active extract of the supra-renal cortex.

First practical method of preparing an extract of the active agent of the adrenal cortical hormone. It was named cortin until it was recognized that there are several active agents in the secretion.

1938 CE

#5045.1

The preparation of anti-typhoid serum in the horse for therapeutic use in man.

Typhoid antiserum.

1930 CE

#1193

The preparation of the crystalline ovarian hormone from the urine of pregnant women.

First isolation of a pure crystalline hormone (estrone). Preliminary communication in Amer. J. Physiol., 1929, 90, 329-30.

1933 CE

#1171

The preparation, identification and assay of prolactin – a hormone of the anterior pituitary.

With R. W. Bates and S. W. Dykshorn.

1995 CE

#11019

The private science of Louis Pasteur.

"His biography of Pasteur was viewed as an outstanding work of scholarship which penetrated the secrecy that had surrounded much of the legendary scientist's laboratory work. Geison used Pasteur's laboratory notebooks…

1949 CE

#2578.7

The production of antibodies. 2nd ed.

Burnet and Fenner introduced the “self-marker” concept – natural tolerance to one’s own body constituents depended on their presence at a critical stage of embryonic development.

1932 CE

#2654

The production of cancer by pure hydrocarbons.

Discovery of the carcinogenic properties of dibenzanthracene compounds. With I. Hieger, E. L. Kennaway, and W. V. Mayneord.

1932 CE

#5786

The radium treatment of carcinoma of the breast.

Keynes’s successes with radium in breast cancer established this method of conservative treatment. His first paper on the subject, with the same title, was published in St. Barth. Hosp. Rep., 1927, 60, 91-95.

1900 CE–1901 CE

#3956

The relation of diabetes mellitus to lesions of the pancreas. Hyaline degeneration of the islands of Langerhans.

Mering and Minkowski had focused attention upon the pancreas as the seat of diabetes, Opie’s work was another important step forward; he established the association between failure of the islets of Langerhans an…

1908 CE

#3844

The relation of iodin to the structure of the thyroid gland.

Marks the beginning of Marine’s lifelong study of the thyroid.

1920 CE

#3964

The relation of the islets of Langerhans to diabetes with special reference to cases of pancreatic lithiasis.

Barron confirmed the experimental work of Sobolew. It was whilst reading the above paper that Banting first formulated the hypothesis upon which he based his successful experiments.

1894 CE–1895 CE

#5640

The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June, 1889, to January, 1894.

Halsted’s operation invariably excised the pectoralis major muscle in radical mastectomy. His operation, modified by the retention of the pectoral muscles, remains the cornerstone of surgical treatment of carcin…

2017 CE

#14102

The role of the WI-38 cell strain in saving lives and reducing morbidity.

In 1961 "Hayflick developed the first normal human diploid cell strains for studies on human aging and for research use throughout the world. Prior to his seminal research, all cultured cell lines were immortal and an…

1924 CE

#5084

The significance of Streptococcus hemolyticus in scarlet fever and the preparation of a specific anti-scarlatinal serum by immunization of the horse to Streptococcus hemolyticus-scarlatinae.

Dochez and Sherman immunized a horse by repeated injections of scarlet fever toxin. A serum obtained from the horse blanched a scarlet fever rash and, when injected subcutaneously, caused marked amelioration of the ea…

1923 CE–1924 CE

#2573.2

The soluble specific substance of pneumococcus.

Heidelberger, Avery, and their colleagues made a chemical study of the antigenic constituents of the pneumococcus, separating the polysaccharide antigens.

1962 CE

#3978.5

The story of insulin: Forty years of success against diabetes.

With G. Hetenyi and W. R. Feasby.

1962 CE

#1931.4

The structure of prostaglandin E, F1 and F2.

In this and subsequent papers Bergström and Samuelsson elucidated the chemical structure of prostaglandins. In 1982 the Nobel Prize in Physiology or Medicine was awarded jointly to Sune K. Bergström, Bengt I…

1852 CE

#3262

The surgical treatment of polypi of the larynx and oedema of the glottis.

Green was one of the few to remove a laryngeal tumor before the invention of the laryngoscope.

1945 CE

#2659.4

The synchrotron: a proposed high energy particle accelerator.

In 1951 McMillan shared the Nobel Prize in Chemistry with Glenn Theodore Seaborg "for their discoveries in the chemistry of the transuranium elements."

1953 CE

#1175.3

The synthesis of an octapeptide amide with the hormonal activity of oxytocin.

Synthesis of oxytocin. With C. Ressler, J. M. Swan, C. W. Roberts, P. G. Katsoyannis, and S. Gordon. In 1955 Vigneaud was awarded the Nobel Prize in Chemistry "for his work on biochemically important sulphur compounds…

1951 CE

#13595

The technique of free skin grafting in mammals.

This "paper facilitated the later discovery of `actively acquired tolerance' and the definition of the principal laws of transplantation tolerance. Thus, it was in a series of classic experiments (stemming from this J…

1990 CE

#2662.5

The theory and practice on oncology. Historical evolution and present principles.

1952 CE

#1155.2

The total synthesis of steroids.

Synthesis of cortisone by Woodward and colleagues. With F. D. Taub, K. Heusler, and W. M. McLamore.