Facets

1910 CE

#5042

The control of typhoid in the Army by vaccination.

Russell carried out important and long-continued investigations on anti-typhoid vaccination in the U.S. Army, demonstrating beyond question its value in selected groups. The war of 1914-18 confirmed the value of the w…

1969 CE

#2578.39

The covalent structure of an entire ÁG immunoglobulin molecule.

Complete sequence of an immunoglobulin molecule. With five coauthors. In 1972 Edelman shared the Nobel Prize in Physiology or Medicine with R. R. Porter “for their discoveries concerning the chemical structure o…

1900 CE

#14167

The Croonian lecture. -- On immunity with special reference to cell life.

Ehrlich's "lock and key" theory of antibody antigen relationship, or interaction, in which the toxin molecule (i.e the antigen) binds to the cell receptor, and then the antibody binds in a lock and key manner to the t…

1909 CE

#2635

The Croonian Lectures on radioactivity and carcinoma.

1905 CE

#1122

The Croonian Lectures on the chemical correlation of the functions of the body.

Starling constructed a general scheme of the “hormones” as he named the internal secretions. This is the first appearance of the word, which was suggested by W. B. Hardy.

1981 CE

#4158.2

The dermatology and syphilology of the nineteenth century.

A scholarly work written in a particularly entertaining style.

1933 CE

#1377.1

The dermatomes in man.

1946 CE

#2659.5

The design of a proton linear accelerator.

Linear ion accelerator. In 1968 Alvarez received the Nobel Prize in Physics "for his decisive contributions to elementary particle physics, in particular the discovery of a large number of resonance states, made possi…

1950 CE

#12821

The diagnosis and treatment of endocrine disorders in childhood and adolescence.

The first textbook of pediatric endocrinology.

1941 CE

#6135

The diagnostic value of vaginal smears in carcinoma of the uterus.

The first cytopathology test, smear diagnosis of carcinoma of the cervix: the "Pap" test. Papanicolaou first reported in 1928 that he could recognize cancer cells (Proc. Third Race Betterment Conf., p. 528) but the im…

1982 CE

#3979.1

The discovery of insulin.

1955 CE

#1207

The disulphide bonds of insulin.

Sanger sequenced the amino acids of insulin, the first of any protein. His work “revealed that a protein has a definite constant, genetically determined sequence—and yet a sequence with no general rule for…

1996 CE

#12111

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.

Order of authorship in the original publication: Lemaitre, Nicolas,... Hoffmann. This paper represented the foundation of molecular immunology. Hoffmann and colleagues found that flies with mutated Toll genes were una…

1905 CE

#4266.1

The early diagnosis and radical cure of carcinoma of the prostate. Being a study of 40 cases and presentation of a radical operation which was carried out in four cases.

First radical prostatectomy for carcinoma.

1921 CE

#1163

The effect of the anterior lobe administered intraperitoneally upon growth, maturity and oestrus cycles of the rat.

Evans and Long discovered the growth hormone of the anterior pituitary, showing that continued injections of an anterior pituitary extract produced an acceleration in the growth-rate of laboratory animals.

1927 CE

#1187

The effect of the injection of a lipoid fraction of bull testicle in capons.

McGee prepared the first active male hormone extract from the lipoid fraction of bull testes. His paper includes a preliminary account of the capon-comb test. See No. 1191.

1929 CE

#1191

The effects of extracts of testis in correcting the castrated condition in the fowl and in the mammal.

C. R. Moore, T. F. Gallagher, and F. C. Koch were the first to obtain a potent testicular extract containing the male sex hormone, androsterone, later obtained in crystalline form by Butenandt. They also gave a detail…

1957 CE

#2578.21

The effects of the continuous re-infusion of lymph and lymphocytes on the output of lymphocytes from the thoracic duct of unanaesthetized rats.

Gowans’s work, particularly between 1957 and 1962, was mainly responsible for the fusion of studies on the lymphocytes with the mainstream of immunology. The above paper dealt with the recirculation of lymphocyt…

1923 CE

#7407

The elephant man and other reminiscences.

The story of Treves's patient, Joseph Carey Merrick (1862-1890), incorrected identified by Treves in these reminiscences as "John Merrick." The story was retold in The elephant man, Bernard Pomerance's 1977 play about…

2010 CE

#7862

The emperor of all maladies: A biography of cancer.

1939 CE

#3802

The endocrine glands

Goldzieher dealt very fully with the history, theory, and practice of endocrinology.

1936 CE

#3909

The endocrine organs in health and disease. With an historical review.

"As a history of the subject, this work is unsurpassed in detail and accuracy" (L.T. Morton).

2009 CE

#12144

The evolution of obesity.

1917 CE

#1182

The existence of a typical oestrus cycle in the guinea-pig; with a study of its histological and physiological changes.

The vaginal smear test for estrus; it demonstrates the histological changes occurring in the vagina during the menstrual cycle.

1925 CE

#1136

The extraction of a parathyroid hormone which will prevent or control parathyroid tetany and which regulates the level of blood calcium.

Isolation of parathormone, the active principle of the parathyroids. Collip’s “parathormone”. He showed that it raises the calcium level in para-thyroidectomized dogs.

1943 CE

#2578.4

The fate of skin homografts in man.

Gibson and Medawar placed the laws of transplantation on a firm scientific basis. A later paper by Medawar (J. Anat. [Lond.], 1944, 78, 176- 99) demonstrated that the mechanism of rejection of transplanted tissues is …

1929 CE

#7186

The female sex hormone. Part I: Biology, pharmacology and chemistry. Part II: Clinical investigations based on the female sex hormone blood test.

The first handbook on female sex hormones. Digital facsimile from the Hathi Trust at this link.

1913 CE

#3540

The first successful case of resection of the thoracic portion of the oesophagus for carcinoma.

See also Arch. Surg. (Chicago), 1925, 10, 353-60, which reported that the patient was still living.

1924 CE

#2646

The formation of a cancer-producing substance from isoprene (2-methyl-butadiene).

Kennaway produced carcinogenic tars by submitting acetylene or isoprene to high temperatures in an atmosphere of hydrogen, thus proving that some carcinogens are pure hydrocarbons.

1955 CE

#2578.16

The fractionation of rabbit -globulin by partition chromatography.

Preliminary note in Biochem. J., 1954, 58, xxxix-xl. Porter received the Nobel Prize in 1972. See No. 2578.25.

1910 CE

#1161

The functions of the pituitary body.

See No. 3896.

1978 CE

#2662.4

The genesis of cancer. A study in the history of ideas.

1937 CE

#2576.5

The genetic and antigenic basis of tumour transplantation.

Gorer made the initial discoveries which formed the basis of transplantation genetics. He studied mouse blood groups and described an antigen in erythrocytes (antigen II). His studies established the laws of transplan…

1924 CE

#2573.1

The genetics of tissue transplantation in mammals.

Little established that the homograft reaction was due to genetic differences between donor and recipient.

1875 CE

#10451

The geographical distribution of heart disease and dropsy, cancer in females & phthisis in females, in England and Wales. Illustrated by six small and three large coloured maps.

Haviland used the national mortality statistics for England and Wales to develop an elaborate geographical explanation based on map analysis for the cause of heart, cancer, and tuberculosis deaths. He found that femal…

1968 CE

#2578.38

The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism.

Antigen II, discovered by Gorer (No. 2576.5), was studied by Snell and became known as the product of the H-2 locus, the fundamental locus in the history of mammalian transplant biology.

2013 CE

#14101

The haplotype-resolved genome and epigenome of the aneuploidy HeLa cancer cell line.

Adey and colleagues sequenced the haplotype-resolved whole genome of the HeLa cancer cell line. This showed a highly rearranged region at chromosome 8q24.21, where an integration locus of the HPV (human papillomavirus…

1905 CE–1906 CE

#5440

The histology of the skin lesions in varicella.

Tyzzer was first to recognize inclusion bodies in varicella.

1989 CE

#8735

The history of cancer: An annotated bibliography.

1933 CE

#4156

The history of dermatology.

Reprinted, New York, 1976.

1964 CE

#3979

The history of diabetes mellitus. 2nd ed.

1990 CE

#9534

The history of endocrine surgery.

With Friesen, Stanley R.; Johnston, Ivan D.A.; and Sellwood, Ronald A.

2009 CE

#7477

The history of oncology.

1937 CE

#8751

The history of the acute exanthemata.

Smallpox, chicken pox, scarlet fever, measles and German measles. Rolleston was the brother of Sir Humphrey Davy Rolleston.

1958 CE

#2578.24

The homograft reaction.

Medawar showed grafting to be unsuccessful when donor and recipient animals came from the same litter, unless the two are genetically identical – another instance of the delayed hypersensitivity reaction.

1924 CE

#1184

The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone.

Test for recognition of the estrus hormone.

1957 CE

#2660.10

The induction of neoplasms with a substance released from mouse tumors by tissue culture.

Isolation of polymavirus (papovavirus). With B. E. Eddy, A. M. Gochenour, N. G. Borgese, and G E. Grubbs.

1927 CE

#1166

The induction of precocious sexual maturity by pituitary homeotransplants.

Smith was able to induce precocious sexual maturity in mice and rats by the implantation of pituitary tissue.

1915 CE

#2569

The influence of the x-ray on the production of antibodies.

Proof that x rays suppress the antibody response.

2019 CE

#11477

The integrative human microbiome project.

Results from this large research consortium show the influence of the microbiome on preterm birth, inflammatory bowel disease, including Crohn's and ulcerative colitis, and prediabetes leading to type II diabetes. (Th…