Facets

1946 CE

#9338

Radioactive iodine therapy: Effect on functioning metastases of adenocarcinoma of the thyroid.

Seidlin and Marinelli described the first successful treatment of a patient with thyroid cancer metastases using radioiodine (I-131). This paper demonstrated the potential of nuclear medicine as a medical specialty.

1993 CE

#7182

Radiological oncologists: The unfolding of a medical specialty.

1939 CE

#3787.2

Radiotherapy in Hodgkin’s disease (malignant granulomatosis). Anatomic and clinical foundations; governing principles; results.

Gilbert was among the first to achieve durable responses to radiotherapy in Hodgkin’s disease.

1947 CE

#6234

Reacción diagnóstica del embarazo en la que se usa el sapo macho como animal reactivo.

Male toad test. An English account is in J. clin. Endocr., 1947, 7, 653-58.

1896 CE

#2550

Recherches de la réaction agglutinante dans le sang et le sérum desséchés des typhiques et dans la sérosité des vesicatoires.

Developing the work of Gruber and Durham, Widal noted that a patient’s serum could be tested with bacteria of known type and his disease identified by this means. They demonstrated specific agglutinins in the bl…

1856 CE

#1140

Recherches expérimentales sur la physiologie et la pathologie des capsules surrénales.

Brown-Séquard found that excision of both adrenals in animals invariably proved fatal, thus determining their indispensability. He also believed that they had an antitoxic influence upon the blood. His experime…

1824 CE

#10184

Recherches pour server à l'histoire des maladies du système lymphatique.

First description of lymphangitis carcinomatosa. See L. Doyle, "Gabriel Andral (1797-1876) and the first reports of lymphangitis carcinomatosa," Journal of the Royal Society of Medicine, 82 (1989) 491-93.

1853 CE

#7313

Recherches sur la nature et le traitement des teignes.

Bazin proved the fungal origin of favus and tinea; this was the first work to incorporate mycotic skin diseases into dermatological literature. Digital facsimile from BnF Gallica at this link.

1843 CE

#4035

Recherches sur la nature, le siège et le développement du Porrigo decalvans ou phytoalopécie.

First accurate description of Microsporon audouini, the fungus of Willan’s porrigo decalvans, tinea tonsurans, “Gruby’s disease”.

1877 CE

#534.65

Récherches sur la production artificielle des monstruosités, ou essais de teratologénie expérimentale.

Dareste devoted his career to experimental teratology, and in this work established the field as a science. The second edition (1891) was greatly revised and enlarged. Contains a valuable history of experimental terat…

1938 CE

#2576.7

Recherches sur le phénomène de Twort-d’Hérelle (bactériophage ou autolyse hérédo-contagieuse).

The Wollmans made important contributions to the knowledge on bacteriophage and lysogeny.

1921 CE

#3965

Recherches sur le rôle du pancréas dans l’assimilation nutritive.

Paulesco isolated the anti-diabetic hormone of the pancreas before Banting and Best. He named it “pancréine”.

1829 CE

#2610

Recherches sur le traitement du cancer par la compression méthodique. 2 vols.

Récamier was the first to recognize the process of metastasis. He also described for the first time invasion of veins by cancer.

1884 CE

#4082.1

Recherches sur les caractères anatomiques du xanthélasma.

First description of skin changes and necropsy findings in pseudoxanthoma elasticum. See No. 4096.1 and Trans. St. John’s Hosp. Derm. Soc., 1972, 58, 235-50 (F.M. Pope).

1880 CE–1882 CE

#11153

Recherches sur les difformités congénitales chez les monstres, le foetus et l'enfant.

Published as Vol. 1 of Oeuvres de Docteur Jules Guerin, of which this work was all published. Digital facsimile from Google Books at this link.

1775 CE

#1117

Recherches sur les maladies chroniques. Vol. 1. Analyse médicinale du sang.

De Bordeu first conceived the idea of internal secretion by his hypothesis that every organ, tissue, and cell discharges into the blood products which influence other parts of the body. His work was published in a col…

1844 CE

#4036

Recherches surles cryptogames qui constituent la maladie contagieuse du cuir chevelu décrite sous le nom de Teigne tondante (Mahon). Herpes tonsurans (Cazenave).

Gruby discovered a fungus, Trichophyton tonsurans, in ringworm of the scalp.

1473 CE

#6316

Regiment der jungen Kinder.

This work has very little originality, being mainly derived from the Arabic physicians of 500 years before, but is noteworthy as being the first book on pediatrics printed in German. It includes what is probably the f…

1928 CE

#4152

Relapsing febrile nodular nonsuppurative panniculitis.

See No. 4151.

1900 CE

#5039

Remarks on the results which have been obtained by the antityphoid inoculations.

The active inoculation of man against typhoid was first performed by Wright in 1896. For a preliminary note see Lancet, 1896, 2, 807.

1867 CE

#3274

Removal of a fibrous polyp from the inferior anterior surface of the right vocal cord with the aid of the laryngoscope.

First successful operation for cancer of the larynx.

1922 CE

#5630.1

Removal of intrathoracic tumours by the trans-sternal route.

Dunhill’s operation for the removal of intrathoracic tumors.

1910 CE

#3534

Removal of the rectum for cancer: statistical report of 120 cases.

Mayo’s radical operation for carcinoma of the rectum.

1828 CE–1829 CE

#3814

Removal of the right lobe of the thyroid gland.

To Joseph Green, of St. Thomas’s Hospital, London, is accredited the first thyroidectomy, the patient succumbing 15 days later from sepsis.

1976 CE

#13976

Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m7G(5')ppp(5')GmpCp.

Furuichi, working in Shatkin's laboratory, discovered that the viral mRNAs synthesized in vitro by the virion-associated RNA polymerase of reovirus contain a unique 5′-terminal structure m7GpppNm or cap. The pre…

1862 CE

#3936

Researches on the nature and treatment of diabetes

Pavy devoted many years to the study of diabetes. He concluded that there was a definite relationship between the degree of hyperglycemia and glycosuria.

1937 CE

#3660

Resection of head of pancreas and duodenum for carcinoma – pancreatoduodenectomy.

See also the same journal, 1943, 77, 581-84.

1974 CE

#7453

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

Doherty and Zinkernagel discovered how a class of white blood cells known as T cells kill virus-infected cells in the body, and so present the spread of viruses. In 1998 Zinkernagel and Doherty were awarded the Nobel …

1869 CE

#3938

Retinitis in glycosuria.

First investigation of retinitis accompanying glycosuria.

1875 CE

#4499.1

Rhumatisme articulaire subaigu avec production de tumeurs multiples dans les tissus fibreux périarticulaires et sur le périoste d’un grand nombre d’os.

Meynet was the first to draw special attention to the subcutaneous fibroid nodules in rheumatism.

1970 CE

#2660.23

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…

2020 CE

#13506

Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine.

BNT162b2 is synonomous with the Pfizer BioNTech mRNA Covid-19 vaccine. The Pfizer-BioNTech mRNA vaccine was produced from theoretical design to finished product and distribution in less than one year. This was the fir…

1900 CE–1910 CE

#3919

Sammlung klinischer Abhandlungen über Pathologie und Therapie der Stoffwechsel- und Ernährungsstörungen. 9 pts.

Noorden succeeded Nothnagel at Vienna. He made important studies of metabolism and its disorders. His section on obesity was translated into English as Obesity: the indications for reduction cures. Part 1 of Clinical …

1731 CE

#2275

Samuel Sontag: Dissertatio inauguralis medica de metastasi sive sede morborum mutata oder: Wie sich öffters eine Kranckheit in die andere verwandele. Praeside Hoffmanno.

Recamier (1829) is credited with coining the term metastasis with respect to cancer. It is evident that Hoffmann and his pupil Sontag used the term nearly 100 years earlier in this general thesis on disease. They did …

1879 CE

#4346

Sarcoma of the long bones; based upon a study of one hundred and sixty-five cases.

First comprehensive work on bone sarcoma.

1942 CE

#2578.1

Sensitization to horse serum by means of adjuvants.

Freund’s adjuvant. Freund’s procedure allowed adjuvants to be used for any antigen.

1958 CE

#2578.25

Separation and isolation of fractions of rabbit gamma-globulin containing the antibody and antigenic combining sites.

In 1972 Porter shared the Nobel Prize in Physiology or Medicine with G.M. Edelman (No. 2578.39) "for their discoveries concerning the chemical structure of antibodies."

1932 CE

#5179

Serum treatment of tularemia.

Foshay devised a serum for the treatment of tularemia.

1846 CE–1848 CE

#3912.1

Several specimens of cystine exhibited, with the particulars of two cases in which this deposit occurred in the urine.

Cystinuria described.

1932 CE

#1197

Sex and internal secretions; a survey of recent research.

Second edition, 1939, with C. H. Danforth and E. A. Doisy.

1906 CE

#3890

Sexual infantilism with optic atrophy in cases of tumor affecting the hypophysis cerebri.

1897 CE

#10597

Skin diseases of children. With twelve photogravure and chromographic plates, and sixty illustrations in the text.

Digital facsimile from the Internet Archive at this link.

1950 CE

#3215.2

Smoking and carcinoma of the lung. Preliminary report.

A study of 1,465 cases of lung cancer and 1,465 matched controls, which confirmed and extended the studies of Wynder and Graham, and others. See also later papers by the same authors in Brit. med. J., 1952, 2,1271-86;…

1964 CE

#7385

Smoking and health: report of the Advisory Committee to the Surgeon General of the Public Health Service.

Definitive 386-page throughly documented study of the carcinogenic and pulmonologic effects of smoking, and the addictive aspects of nicotine. It was published under the supervision of Surgeon-General Luther Terry. Di…

1932 CE

#13289

Sobre in caso de galactorrea y amenorrea.

Ahumada-Del Castillo syndrome: galactorrhoea-amenorrhoea not associated with pregnancy; oestrogen deficiency and decreased urinary gonadotropin levels.

1914 CE

#5301

Sobre o tratemento de leishmaniose tegumentar.

Vianna introduced tartar emetic in the treatment of S. American leishmaniasis. His preliminary announcement on this form of treatment was made to the Brazilian Dermatological Society and appears in Arch. brasil. Med.,…

1919 CE

#3849.1

Some considerations on the operation for exophthalmic goitre.

Dunhill’s operation of exophthalmic goitre is described above. He was a pioneer in thyroid surgery.

1945 CE

#3855

Some observations on the use of thiobarbital as an antithyroid agent in the treatment of Graves’s disease.

Clinical introduction of thiobarbital.

1936 CE

#2658

Some possible effects of nursing on the mammary gland tumor incidence in mice.

Bittner’s “milk factor,” the murine mammary tumor involved in the transmission of cancer in mice. See also Amer. J. clin. Path., 1937, 7, 430-35.

1802 CE

#3811

Sopra un tumor freddo nell’anterior parte del collo detto broncocele.

One of the earliest accounts of exophthalmic goitre. The author noted cardiac disturbances in thyroid enlargement.