Facets

1948 CE

#4991.1

Cybernetics: or control and communication in the animal and the machine.

Foundation of "the science of control and communication theory, named ‘cybernetics’ by Wiener, from the Greek word ‘kubernetes’ or steersman. Automation, information feedback, regulators in eng…

1963 CE

#12427

Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells.

McCulloch and Till discovered the blood-forming stem cell, the hematopoietic stem cell (HSC), through their pioneering work in mice. McCulloch and Till began a series of experiments in which bone marrow cells were inj…

1892 CE

#641

Das Gesetz der Transformation der Knochen.

“Wolff’s law” stated that every change in form and function of a bone, or in its function alone, is followed by certain definite changes in its internal architecture and equally definite secondary al…

1962 CE

#8484

Data acquisition and processing in biology and medicine. Proceedings of the 1961 Rochester conference. Edited by Kurt Enslein.

Records of the first conference on "biomedical data processing" held in a medical school in the United States.

1704 CE

#10160

De imperio solis ac lunae in corpora humana, et morbis inde oriundis.

Mead formulated the position that periodic atmospheric tides arising from planetary forces produced alterations of gravity, elasticity, and air pressure; these changes, he argued, affected the human body in health and…

1680 CE–1681 CE

#3669.3

De motu animalium. 2 pts.

Borelli originated the neurogenic theory of the heart’s action and first suggested that the circulation resembled a simple hydraulic system. He was the first to insist that the heart beat was a simple muscular c…

1650 CE

#3729

De rachitide sive morbo puerili, qui vulgo The Rickets dicitur tractatus.

Although anticipated by Whistler and others in the description of infantile rickets, Glisson’s account was the fullest that had till then appeared. He was first (Chap. 22) to describe infantile scurvy. Glisson&r…

1683 CE

#4162

De urinis et pulsibus de missione sanguinis de febribus de morbis capitis, et pectoris.

Bellini began to develop his hydraulic iatromechanics in this work, in which he considered the blood as a physical fluid with simple mechanical and mathematicizable properties. He realized the value of the urine as an…

1667 CE

#9644

De vi percussionis liber.

Building on the theory of mechanics as formulated by Aristotle and Galileo, and countering objections expressed by Stephani degli Angeli among others, Borelli presented a completely mechanical account of the action of…

1895 CE–1904 CE

#645

Der Gang des Menschen. 1-6 Abt. (All published.)

Classic study of the human gait. The authors calculated the external and internal forces involved in walking and described the kinematics and kinetics of the movement. Because of Braune's death in 1892 he could only c…

1909 CE

#12426

Der Lymphozyt als gemeinsame Stammzelle der verschiedenen Blutelemente in der embryonalen Entwicklung und im postfetalen Leben der Säugetiere.

Maximow developed and introduced a unitarian theory of hematopoiesis, a theory upon which the modern concept of blood cells' origin and differentiation is based. He introduced the term "stem cell." Translated into Eng…

1935 CE

#4400.5

Der Schenkelhalsbruch, Ein mechanische Problem.

Pioneering study of the biomechanics of the hip joint.

1998 CE

#13977

Derivation of pluripotent stem cells from cultured human primordial germ cells.

Order of authorship in the original publication: Shamblott, Axelman,... Gearheart. Gearheart led the team that successfully developed human embryonic germ cells, pluripotent stem cells derived from primordial germ cel…

2013 CE

#10564

Design for information: An introduction to the histories, theories, and best practices behind effective information visualizations.

Visually splendid; includes frequent comparisons of modern computer representations with historical examples.

1908 CE

#12276

Design in nature illustrated by spiral and other arrangements in the inorganic and organic kingdoms as exemplified in matter, force, life, growth, rhythms, &c., especially in crystals, plants, and animals. 3 vols.

"Illustrated by nearly two thousand figures, mostly original and from nature." Digital facsimile from the Internet Archive at this link.

2003 CE

#14300

Design of a novel globular protein fold with atomic-level accuracy.

Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with convention…

2009 CE

#13728

Detecting influenza epidemics using search engine query data.

Abstract "Seasonal influenza epidemics are a major public health concern, causing tens of millions of respiratory illnesses and 250,000 to 500,000 deaths worldwide each year1. In addition to seasonal influenza, a new …

2007 CE

#7994

Development of the Medical Literature Analysis and Retrieval System (MEDLARS).

Digital version from PubMedCentral at this link.

1891 CE

#637

Die Bewegungen des Kniegelenkes.

Investigation of the mechanics of motion of the knee joint on mathematical lines. See also No. 645.

1899 CE

#12286

Die Grundform des arteriellen Pulses.

"The First Mathematical Description of the Pressure-Volume Diagram "Not until 60 years after 1899 Otto Frank's mathematical formulation of the volume-pressure diagram and his concept of the mechanism of the cardiac wo…

1983 CE

#12061

Differential equations and mathematical biology.

"This textbook shows how first-order ordinary differential equations (ODEs) are used to model the growth of a population, the administration of drugs, and the mechanism by which living cells divide. The authors presen…

2018 CE

#10121

Digital health: Scaling healthcare to the world. Edited by Homero Rivas and Katarzyna Wac.

Probably the first book published on "digital health." "This book presents a comprehensive state-of the-art approach to digital health technologies and practices within the broad confines of healthcare practices. It p…

2018 CE

#12183

Digital medicine, on its way to being just plain medicine.

"There are already nearly 30,000 peer-reviewed English-language scientific journals, producing an estimated 2.5 million articles a year.1 So why another, and why one focused specifically on digital medicine? "To answe…

1959 CE

#11560

Digital recording of electrocardiographic data for analysis by a digital computer.

This is probably the earliest paper on the use of computers to analyze electrocardiograms. The abstract: "A corrected orthogonal 3-lead system has been used to record electrocardiograms directly from patients at Veter…

1738 CE

#11713

Dissertatio de structura et motu musculari.

This was the text of the first Croonian Lecture at the Royal Society. In it Stuart promoted a strictly hydraulic iatromechanism as a theory of muscular motion. This work was translated into English in 1739. Digital fa…

1694 CE

#10492

Dissertatio inauguralis physico-anatomica de motu musculorum.

Digital facsimile from e-rara.ch at this link. Facsimile edition translated into English, with a related thesis by Bernouilli, by Paul Macquet, assisted by August Zigellar, with an introduction by Troels Kardel as Dis…

2021 CE

#13507

Efficacy and safety of the mRNA-1273 SARSCov-2 vaccine.

mRNA-1273 is synonymous with the Moderna mRNA Covid-19 vaccine. The Moderna mRNA vaccine was produced from theoretical design to finished product and distribution in less than one year. This was the first published pa…

1860 CE

#4972

Elemente der Psychophysik. 2 vols.

The first treatise on the subject. Fechner applied the laws of mathematical physics to the physiology of sensation. He discussed the functional relations of the dependence between mind and body and investigated the cu…

1667 CE

#577

Elementorum myologiae specimen.

In this work Stensen, in collaboration with the mathematician Vincenzio Viviani (1622-1703), a pupil of Galileo, developed a geometrical description of muscular contraction, and attempted to show theoretically that mu…

1998 CE

#13286

Embryonic stem cell lines derived from human blastocysts.

Thomson and collaborators first isolated embryonic stem cells from human blastocysts. Order of authorship in original publication: Thomson, Itskovitz-Eldor, Shapiro et al. Available online from science.sciencemag.org …

1864 CE

#1700.1

English life table. Tables of lifetimes, annuities, and premiums.

First extensive application of a mechanical computer to medical statistics. The appendix details the use of the Scheutz version of Charles Babbage’s calculating machine in the construction of English Life Table …

1924 CE

#907.1

Ergebniss einer biostatischen zusammenfassenden Betrachtung über die erblichen Blutstrukturen des Menschen.

Bernstein, a mathematician, determined the correct blood group inheritance pattern of multiple alleles at one locus through statistical analysis.

1981 CE

#13285

Establishment in culture of pluripotential cells from mouse embryos.

Evans and Kauffman were the first to identify, isolate and successfully culture embryonic stem cells using mouse blastocysts. This discovery opened the doors to the creation of “murine genetic models” -- m…

1968 CE

#7948

Evaluation of the MEDLARS demand search service.

The first large-scale evaluation of a "major operating information system." A detailed analysis of the performance of the Medical Literature and Analysis System (MEDLARS) in relation to 300 actual "demand search" requ…

1931 CE

#253.1

Evolution in Mendelian populations.

First detailed presentation of Wright’s quantitative theory of the effects of mutation, migration, selection, and population size on changes in gene frequencies in populations. Digital facsimile from Genetics.or…

1969 CE

#7487

Exploring the ocean world: A history of oceanography.

1977 CE

#10964

Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin.

Order of authorship in the original paper: Itakura, Hirose, Crea..., Bolivar, Boyer. Synthesis of the gene for somatostatin (growth hormone-inhibiting hormone (GHIH). This was the first demonstration of a foreign gene…

1979 CE

#13980

Expression in Escherichia coli of chemically synthesized genes for human insulin (plasmid construction / lac operon / fused proteins / radioimmunoassay / peptide purification).

Working at Genentech, Kleid and Goeddel and colleagues were the first scientists to apply genetic engineering techniques, incorporating chemically synthesized DNA encoding human insulin into E. coli, that expressed, a…

1983 CE

#13989

Expression of chimaeric genes transferred into plant cells using a Ti-plasmid-derived vector.

Schell and Montagu discovered the gene transfer mechanism between Agrobacterium and plants, which resulted in the development of methods to alter Agrobacterium into an efficient delivery system for gene engineering in…

2012 CE

#12751

Eyewire: A game to map the brain.

https://eyewire.org/explore Eyewire is a game to map the brain from Sebastian Seung's Lab at Princeton University. This citizen science human-based computation game challenges players to map retinal neurons. Eyewire l…

2005 CE

#9935

Fathoming the ocean: The discovery and exploration of the deep sea.

1986 CE

#13990

Fluorescence detection in automated DNA sequence analysis.

Invention of the first semi-automated DNA sequencing machine by Leroy H. Hood, Lloyd M. Smith and colleagues. Abstract of the paper: "We have developed a method for the partial automation of DNA sequence analysis. Flu…

2005 CE

#8201

From Gutenberg to the internet: A sourcebook on the history of information technology. Edited by Jeremy M. Norman.

Includes some documentation on the early applications of computing to biology and medicine.

2011 CE

#8673

Genentech: The beginnings of biotech.

1974 CE

#10963

Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.

Confirmation of the success of methods outlined in No. 257.5. Abstract: "Genes carried by EcoRI endonuclease-generated fragments of Staphylococcus plasmid DNA have been covalently joined to the E. coli antibiotic-resi…

1970 CE

#8380

George A Sacher, Life table modification and life prolongation. IN: Handbook of the biology of aging, edited by Caleb E. Finch and Leonard Hayflick, pp. 582–638.

"The building of a connection between the Gompertz equation and the biology of ageing owes much to the work of biophysicist George Sacher [10] of the Argonne National Laboratory, whose introduction to ageing stemmed f…

2020 CE

#12182

Harnessing wearable device data to improve state-level real-time surveillance of influenza-like illness in the USA: A population-based study.

Order of authorship in the original publication: Radin, Wineinger, Topol, Steinhubl. "Background "Acute infections can cause an individual to have an elevated resting heart rate (RHR) and change their routine daily ac…

1979 CE

#9769

Health, medicine and mortality in the sixteenth century. Edited by Charles Webster.

Chapter 11 is an analysis of the life and work of librarian and key early pioneer in medical informatics, Sanford V. Larkey by Margaret Pelling. Another chapter, by Paul Slack, “Mirrors of health and treasures o…

2021 CE

#14026

Highly accurate protein structure prediction with AlphaFold.

Abstract: "Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1,2,3,4, the structures of around 100,0…

2017 CE

#13721

History of social media in surgery.

Order of authorship in the original publication: Logghe, McFadden, Tully, Jones. Full text from PubMedCentral at this link.