Design of a novel globular protein fold with atomic-level accuracy.

Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with conventional cryoEM or crystallography. In 2024 Baker shared half of the Nobel Prize in Chemistry with Demis Hassabis and John Jumper for "revealing protein's secrets through computing and artificial intelligence."

Order of authorship in the original publication: Kuhlman, Dantas, Ireton, Varani...Baker. 

(Thanks to Juan Weiss for this reference and its interpretation.)