Facets

1971 CE

#13958

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

In 1982 Vane shared the Nobel Prize in Physiology or Medicine with Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances."

1910 CE

#2637

A transmissible avian neoplasm (sarcoma of the common fowl).

Original description of the chicken sarcoma (Rous sarcoma). Rous demonstrated that sarcomatous tumors in hens could be transmitted to normal hens by the injection of cell-free filtrates (virus) of the original tumor. …

1945 CE

#14284

Acetylation of sulfanilamide by liver homogenates and extracts.

Discovery of co-enzyme A and its importance for intermediary metabolism. This discovery illuminated “the process by which cells make available the energy to drive their manufacturing processes” (Judson, p.…

1937 CE

#1925

Action protectrice des éthers phénoliques au cours de l’intoxication histaminique.

First description of structure and action of an antihistamine. In 1957 Bovet was awarded the Nobel Prize in Physiology or Medicine “for his discoveries relating to synthetic compounds that inhibit the action of …

2014 CE

#13738

Cancer concepts: A guidebook for the non-oncologist.

https://escholarship.umassmed.edu/cancer_concepts/8/ The first interactive Open access (OA) electronic textbook on any medical subject. This eBook was designed for first year medical students. Order of authorship on t…

2017 CE

#10555

Cancer, radiation therapy, and the market.

1970 CE

#14232

Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor.

Working with sheep preparations, the authors determined that the molecular structure of TRF (thyroid releasing hormone), is 2-pyrrolidone-5-carboxylyl-histidyl-L-proline amide. On page 324, they showed the molecular s…

2020 CE

#13039

Clean: The new science of skin.

"A preventative medicine physician and staff writer for The Atlantic explains the surprising and unintended effects of our hygiene practices in this informative and entertaining introduction to the new science of skin…

1826 CE

#10529

Clinique de la maladie syphilitique. Enrichie d’observations communiquées par messieurs Cullerier oncle, Cullerier neveu, Bard, Gama, Desruelles et autre médecins. Text and atlas.

Includes 126 hand-colored engraved plates from drawings by Dupont the elder, assisted by Delestre the younger and Verollot, engraved by Johann Theodor Susemihl, a German engraver working in Paris, known for his zoolog…

1975 CE

#2578.43

Continuous cultures of fused cells secreting antibody of predefined specificity.

Hybridomas. In 1984 Köhler and Milstein shared the Nobel Prize in Physiology or Medicine with Niels K. Jerne, "for theories concerning the specificity in development and control of the immune system and the disco…

1895 CE

#2547

Contribution à l’ étude du sérum chez les animaux vaccinés.

In Bordet’s classic paper on the properties of the sera of immunized animals he showed that two different substances (now known as sensitizing antibody and complement) are involved in the phenomenon of bacteriol…

1949 CE

#4671.1

Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissues.

Enders, Weller, and Robbins grew the poliomyelitis virus in cultures of different tissues. Their method proved of great value in virus research, and removed the final obstacles to vaccine production. In 1974 Enders, W…

1577 CE

#7990

De arte medica infantium libri quatuor. Quorum duo Priores de tuenda eorum sanitate, posteriores de curandis morbis agunt.

An early illustrated work on pediatrics. The three parts of his book deal with the management of the nurse and her milk, the care and feeding of the new-born, and diseases of children, including skin diseases, and cha…

1902 CE

#2590

De l’action anaphylactique de certains venins.

First full description of the phenomenon of “anaphylaxis,” the name of which was coined by Richet. Abbreviated English translation in Bibel, Milestones of immunology (1988). In 1913, Richet was awarded the…

1907 CE

#2599

De l’anaphylaxie en général et de l’anaphylaxie par la mytilocongestine en particulier.

In 1913 Richet was awarded the Nobel Prize in Physiology or Medicine "in recognition of his work on anaphylaxis."

1865 CE

#168

De la chevelure comme caractéristique des races humaines.

Pruner-Bey did the first important work on the classification of races according to texture and shape in section of hair. Digital facsimile from Persee.fr at this link.

1998 CE

#12112

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the Tlr4 gene.

Order of authorship in the original paper: Poltorak, Smirnova...Beutler. The authors, led by Beutler, showed that mice that harbor a mutation of the gene which codes for the production of the Toll-like receptor TLR4 q…

1897 CE

#5064

Die Wertbestimmung des Diphtherieheilserums.

Ehrlich improved Behring’s diphtheria antitoxin through quantitative titration and established an international standard for this and other antitoxins. This was the beginning of the concept of biological standar…

1976 CE

#2660.28

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Discovery of the first “oncogene. In 1989 Varmus and Bishop shared the Nobel Prize for in Physiology or Medicine "for their discovery of the cellular origin of retroviral oncogenes."

1996 CE

#14267

Enhancement of antitumor immunity by CTLA-4 blockade.

In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as …

1976 CE

#14245

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

Discovery of V(D)J recombination, the genetic mechanism which produces antibody diversity. In 1987 Tonegawa was awarded the Nobel Prize in Physiology or Medicine "for his discovery of the genetic principle for generat…

1878 CE

#3826

Exstirpation einer Struma retroesophagea.

Kocher, a pupil of Billroth, was a pioneer of thyroidectomy for goitre. Before his time the operation was seldom performed. Garrison says that Kocher performed this difficult operation 2,000 times, with a mortality ra…

1975 CE

#2660.27

From the molecular biology of oncogenic DNA viruses to cancer. Les Prix Nobel en 1975, pp. 172-80.

In 1975 Dulbecco shared the Nobel Prize in Physiology or Medicine with David Baltimore and Howard Martin Temin "for their discoveries concerning the interaction between tumour viruses and the genetic material of the c…

1967 CE

#12662

Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells.

Hausen and colleagues showed for the first time that a cancer virus (Epstein-Barr virus) can transform healthy cells (lymphocytes) into cancer cells. This showed that viruses can cause cancer cell formation. (Order of…

1958 CE

#2578.30

Histocompatibility genes of the mouse.

Snell made fundamental contributions to transplantation genetics. At his suggestion genes governing transplantation were called histocompatibility genes and Gorer’s Antigen II became Histocompatibility-2 (H-2). …

1972 CE

#2578.29

Histocompatibility-linked immune response genes.

Benacerraf and McDevitt discovered that the capacity to mount certain immune responses is genetically determined. In 1980 Benacerraf shared the Nobel Prize in Physiology or Medicine with J. Dausset and G. D. Snell "fo…

1973 CE

#11074

Identification of a novel cell type in peripheral lymphoid organs in mice. I. Morphology, quantitation, tissue distribution.

Order of authorship in the original publication: Steinman, Cohn. In this paper Steinman announced his discovery of the dendritic cell. Digital facsimile from PubMedCentral at this link. In 2011 Steinman received half …

1960 CE

#2578.28

Immunosassay of endogenous plasma insulin in man.

First radioimmunoassay of a hormone, a test capable of estimating nonogram or even picogram quantities. In 1977 Yalow received half of the Nobel Prize in Physiology or Medicine "for the development of radioimmunoassay…

1992 CE

#14268

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

Honjo discovered the programmed cell death protein 1 (PD-1). This discovery significantly contributed to the establishment of cancer immunotherapy principle by PD-1 blockade. Order of authorship in the original public…

1957 CE

#13594

Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy.

Thomas and colleagues reported the first bone marrow transplants. They described the treatment of six patients with cancers and/leukemia and one patient with multiple myeloma. Three of the patients died, two responded…

1958 CE

#2578.26

Iso-leuco-anticorps.

Discovery of the first histocompatibility antigen. In 1980 Dausset shared the Nobel Prize in Physiology or Medicine with B. Benacerraf and G. D. Snell "for their discoveries concerning genetically determined structure…

1901 CE

#2555

L’immunité dans les maladies infectieuses.

A classic study of the mechanisms concerned in specific antibacterial immunity, and one of Metchnikoff’s best works. Russian edition: Nevospriimchivost’ k infekcionnim boleznyam. St. Petersburg: K.L. Rikke…

1930 CE

#1169

La diabetes pancreática de los perros hipofisoprivos.

Houssay’s depancreatized hypophysectomized dog. This work led to Houssay’s demonstration of the importance of the anterior pituitary in sugar metabolism. See also Endocrinology, 1931,15, 511-23. In 1947 Ho…

1563 CE–1564 CE

#1093

Opuscula anatomica.

Eustachius is credited with several anatomical discoveries, among them the tensor tympani muscle and the Eustachian tube, published in his chapter entitled De auditus organis. In the last respect, however, he was anti…

1974 CE

#7453

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

Doherty and Zinkernagel discovered how a class of white blood cells known as T cells kill virus-infected cells in the body, and so present the spread of viruses. In 1998 Zinkernagel and Doherty were awarded the Nobel …

1970 CE

#2660.23

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…

1958 CE

#2578.25

Separation and isolation of fractions of rabbit gamma-globulin containing the antibody and antigenic combining sites.

In 1972 Porter shared the Nobel Prize in Physiology or Medicine with G.M. Edelman (No. 2578.39) "for their discoveries concerning the chemical structure of antibodies."

1971 CE

#14231

Structure of the porcine LH-and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses.

Publication in May 1971: Working with pig preparations, the authors reinvestigated the peptide that they had previously isolated, which acted as an LH-FSH releasing hormone. They performed an Edman-dansyl degradation …

1941 CE

#4276

Studies on prostatic cancer. I. The effect of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate.

In 1966 Huggins was awarded the Nobel Prize for Physiology or Medicine for discovering in 1941 "for his discoveries concerning hormonal treatment of prostatic cancer."

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1835 CE

#1698.1

Sur l’homme et le développement des facultés, ou essai de physique sociale. 2 vols.

Quetelet’s statistical researches on the development of the physical and intellectual qualities of man, and an exposition of his concept of the “average man”, which became the by-word of quantitative…

1896 CE

#2001

Sur les radiations émises par phosphorescence.

The discovery of radioactivity – research stimulated by Roentgen’s discovery of x rays. In 1903 Becquerel received half of the Nobel Prize in Physics 1903 "in recognition of the extraordinary services he h…

1898 CE

#2003

Sur une substance nouvelle radio-active, contenue dans la pechblende.

The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…

1959 CE

#2578.31

The clonal selection theory of acquired immunity. The Abraham Flexner Lectures of Vanderbilt University 1958.

Burnet's clonal selection theory extended the idea that each antibody-producing cell makes antibodies of only one specificity, predicting these cells proliferate in response to the detection of antigens, cloning and t…

1969 CE

#2578.39

The covalent structure of an entire ÁG immunoglobulin molecule.

Complete sequence of an immunoglobulin molecule. With five coauthors. In 1972 Edelman shared the Nobel Prize in Physiology or Medicine with R. R. Porter “for their discoveries concerning the chemical structure o…

1946 CE

#2659.5

The design of a proton linear accelerator.

Linear ion accelerator. In 1968 Alvarez received the Nobel Prize in Physics "for his decisive contributions to elementary particle physics, in particular the discovery of a large number of resonance states, made possi…

1955 CE

#1207

The disulphide bonds of insulin.

Sanger sequenced the amino acids of insulin, the first of any protein. His work “revealed that a protein has a definite constant, genetically determined sequence—and yet a sequence with no general rule for…

1922 CE

#3966

The internal secretion of the pancreas. (Abstract).

A preliminary one-page communication regarding the isolation of insulin, made to a meeting of the American Physiological Society in December 1921. Digital facsimile from insulin.library.utoronto.ca at this link. In 19…

1962 CE

#1931.4

The structure of prostaglandin E, F1 and F2.

In this and subsequent papers Bergström and Samuelsson elucidated the chemical structure of prostaglandins. In 1982 the Nobel Prize in Physiology or Medicine was awarded jointly to Sune K. Bergström, Bengt I…

1945 CE

#2659.4

The synchrotron: a proposed high energy particle accelerator.

In 1951 McMillan shared the Nobel Prize in Chemistry with Glenn Theodore Seaborg "for their discoveries in the chemistry of the transuranium elements."