Facets

1966 CE

#14064

"Fertile" intestine nuclei.

Gurdon and Uehlinger replaced the cell nucleus of frog ova with frog intestinal nuclei to generate tadpoles, some of which became fertile adult male and female frogs. In 2012 the Nobel Prize in Physiology or Medicine …

2001 CE–2011 CE

#13227

A History of Speech - Language Pathology.

https://www.acsu.buffalo.edu/~duchan/new_history/overview.html "Organization of the website "The website is divided into six historical periods: History of the ancients: 3000 BC to 500 AD Middle ages: 400 to 1500 AD E…

1841 CE

#543

Allgemeine Anatomie. Lehre von den Mischungs- und Formbestandtheilen des menschlichen Körpers.

Many of the histological discoveries of Henle are described in the above. He classified tissues histologically. In the section on Gefässnerven (pp. 510, 690) Henle demonstrated the presence of smooth muscle in th…

1895 CE

#8653

An atlas of the fertilization and karyokinesis of the ovum.

The first atlas of photomicrographs showing fertilization and cellular development during mitosis. The photomicrographs were taken by Leaming. Digital facsimile from the Internet Archive at this link.

1801 CE

#403

Anatomie générale, appliquée à la physiologie et à la médecine. 4 vols.

Bichat revolutionized descriptive anatomy. Where Morgagni and others had conceived of whole organs being diseased, Bichat showed how individual tissues could be separately affected. He covered tissue pathology, system…

2018 CE

#14146

Cloning of Macaque monkeys by somatic cell nuclear transfer.

The authors at the Chinese Academy of Sciences in Shanghai reported the first cloning of a non-human primate. Full text available from cell.com at this link. Order of authorship in the original publication: Liu, Cai..…

1973 CE

#2700.4

Computerized transverse axial scanning (tomography).

Hounsfield invented computer-assisted tomography (CAT), or computed tomography (CT). In 1979 Hounsfield shared the Nobel Prize in Physiology or Medicine with Allen M. Cormack "for the development of computer assisted …

1965 CE

#8834

Computers in biomedical research. Edited by Ralph W. Stacy and Bruce Waxman. 2 vols.

Section A, Chapter 2: "New mathematical methods in the life sciences" by George B. Dantzig. Section D, Chapter 12: "The application of computers to electroencephalography" by Mary A. B. Brazier. Section E, Chapter 13:…

1855 CE

#1995

De l’électrisation localisée et de son application à la physiologie, à la pathologie, et à la thérapeutique.

Duchenne classified the electrophysiology of the entire muscular system and summed up his findings in the above work. The application of his results to pathological conditions marks him as the founder of electrotherap…

1998 CE

#13286

Embryonic stem cell lines derived from human blastocysts.

Thomson and collaborators first isolated embryonic stem cells from human blastocysts. Order of authorship in original publication: Thomson, Itskovitz-Eldor, Shapiro et al. Available online from science.sciencemag.org …

1981 CE

#13285

Establishment in culture of pluripotential cells from mouse embryos.

Evans and Kauffman were the first to identify, isolate and successfully culture embryonic stem cells using mouse blastocysts. This discovery opened the doors to the creation of “murine genetic models” -- m…

1953 CE

#256.4

Helical structure of crystalline deoxypentose nucleic acid.

In 1962 Wilkins shared the Nobel Prize in Physiology or Medicine with Crick and Watson "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living…

1996 CE

#11183

Historic Embryology Papers.

https://embryology.med.unsw.edu.au/embryology/index.php/Historic_Embryology_Papers#Introduction "Introduction The linked papers are intended to give some historic background to Embryology. Historically, say pre-20th c…

1973 CE

#2700.5

Image formation by induced local interactions: Examples employing nuclear magnetic resonance.

Lauterbur proposed a workable method for using nuclear magnetic resonance to produce images of tissues. In 2003 Lauterbur shared the Nobel Prize in Physiology or Medicine with Sir Peter Mansfield “for their disc…

2006 CE

#13287

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…

1878 CE

#7294

La méthode graphique dans les sciences expérimentales et particulièrement en physiologie et en médecine.

Marey pioneered the use of graphical recording in the experimental sciences, using instruments (many of his own invention) to capture and display data impossible to observe with the senses alone, and to record the pro…

2008 CE

#10550

Making visible embryos.

http://www.sites.hps.cam.ac.uk/visibleembryos/index.html "IMAGES OF HUMAN EMBRYOS Images of human embryos are everywhere. We see them in newspapers, clinics, classrooms, laboratories, family albums and on the internet…

1862 CE

#4973

Mécanisme de la physionomie humaine, ou analyse électro-physiologique de l’expression des passions applicable à la pratique des arts plastiques. Premier fascicule. [All published]. 1 volume of text plus atlas of photographs by Duchenne.

Duchenne studied the mechanism of facial expression during emotion; his atlas of photographs was the first medical book illustrated with photographs of living subjects. Darwin reproduced a number of his photographs in…

1977 CE

#8150

Medical imaging by NMR.

Mansfield developed a mathematical technique that would allow NMR scans to take seconds rather than hours and produce clearer images than the technique Paul Lauterbur developed in 1973. Mansfield showed how gradients …

1883 CE–1884 CE

#831

On the electrical phemomena of the excitatory process in the heart of the frog and of the tortoise, as investigated photographically.

See No. 824. This paper contains several tracings of the heart's electrical activity recorded with a capillary electrometer, the earliest graphic recorder of bioelectric signals. These were the "first undistorted trac…

1686 CE

#66

Opera omnia. 2 vols.

Malpighi was the founder of histology. In 1660 he was the first to see the capillary anastomosis between the arteries and the veins, thus contributing to the completion of Harvey’s work on the circulation. Malpi…

1963 CE

#8149

Representation of a Function by its Line Integrals, with Some Radiological Applications.

Cormack showed that changes in tissue density could be computed from x-ray data. Because of limitations in computing power no machine was constructed during the 1960s. Cormack's papers generated little interest until …

1918 CE–1973 CE

#82

Sebrané spisy. Opera omnia. Tom. 1-12.

Purkynĕ was Professor of Physiology at Breslau and Prague. Eminent as physiologist and microscopist, he was first to use the microtome. See Kruta, V. J.E. Purkynĕ, Physiologist. A short account of his contributions&he…

1987 CE

#13931

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

In 2007 Capecchi shared the 2007 Nobel Prize in Physiology or Medicine with Martin J. Evans and Oliver Smithies "for their discoveries of principles for introducing specific gene modifications in mice by the use of em…

1926 CE–1927 CE

#796

Studies in the velocity of blood flow.

First practical method of measuring circulation time. "In 1925, Hermann Blumgart performed the first diagnostic procedure using radioactive indicators on humans; this first is well recognized. Less well recognized is …

1927 CE

#9335

Studies on the velocity of blood flow: I. The method utilized.

Reports the first diagnostic procedure, done in 1925, using radioactive indicators on humans. "Less well recognized is the fact that Blumgart and his coworker Otto C. Yens, then a medical student, developed the first …

1886 CE

#1416

Sulla fina anatomia degli organi centrali del sistema nervoso.

Golgi’s histological studies made a clear conception of the nervous system possible for the first time. He demonstrated the existence of multipolar nerve-cells (Golgi cells) by means of his silver nitrate stain,…

1987 CE

#13940

Targeted correction of a mutant HPRT gene in mouse embryonic stem cells.

Smithies discovered, simultaneously with Mario Capecchi and Martin Evans, the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previ…

1917 CE

#7116

The fundus oculi of birds especially as viewed by the ophthalmoscope. A study in comparative anatomy and physiology. Illustrated by 143 drawings... also by sixty-one colored paintings prepared for this work by Arthur W. Head.

Digital facsimile from the Biodiversity Heritage Library, Internet Archive, at this link.

1920 CE

#7000

The growth and shedding of the antlers of the deer. The histological phenomena and their relation to the growth of bone.

The first study of the unusual and dramatic physiology of the annual growth and shedding of the antlers of deer. "The amount of bony matter annually secreted to form antlers of the larger deer is enormous, antlers of …

1651 CE

#467.1

The history of generation…

Highmore’s account of the development of the chick is the first embryological study based on microscopical examination, predating Malpighi (No. 468) by more than twenty years. This is also the first book in Engl…

1916 CE

#1331

The involuntary nervous system. Part 1.

This book sums up the life work of Gaskell, who laid the histological foundation of the modern study of the autonomic nervous system. No more published.

1898 CE

#838

Ueber Herzbewegung und Herzstoss.

First employment of cinematograph to record the cardiac changes during all phases of heart contraction.

1997 CE

#7457

Viable offspring derived from fetal and adult mammalian cells.

Cloning of the lamb Dolly, the first mammal to be cloned from an adult cell. Her birth established that the nuclei of at least some adult cells can be used to produce sheep or other animals that are genetically identi…