Facets

1891 CE

#1421

Il cervelletto. Nuovi studi di fisiologia normale e patologica.

Luciani succeeded in keeping dogs alive after total extirpation of the cerebellum, and initiated the modern study of cerebellar function. Digital facsimile from Google Books at this link.

1973 CE

#2700.5

Image formation by induced local interactions: Examples employing nuclear magnetic resonance.

Lauterbur proposed a workable method for using nuclear magnetic resonance to produce images of tissues. In 2003 Lauterbur shared the Nobel Prize in Physiology or Medicine with Sir Peter Mansfield “for their disc…

1960 CE

#2578.28

Immunosassay of endogenous plasma insulin in man.

First radioimmunoassay of a hormone, a test capable of estimating nonogram or even picogram quantities. In 1977 Yalow received half of the Nobel Prize in Physiology or Medicine "for the development of radioimmunoassay…

1954 CE

#14243

In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo.

Discovery of nerve growth factor (NGF). Order of authorship in the original publication: Levi-Montalcini, Meyer, Hamburger. In 1986 Levi-Montalcini was awarded half of the Nobel Prize in Physiology or Medicine, and St…

1944 CE

#532.1

In vitro ferilization and cleavage of human ovarian eggs.

First in vitro fertilization of human eggs.

2018 CE

#10696

In-vitro fertilization: The pioneers' history. Edited by Gabor Kovacs, Peter Brinsden and Alan DeCherney.

Thirty-two chapters devoted to all aspects and some key moments in the history of IVF, together with histories of the development of the science around the world.

1952 CE

#256

Independent functions of viral protein and nucleic acid in growth of bacteriophage.

DNA shown to be the carrier of genetic information in virus reproduction. In 1969 Hershey shared the Nobel Prize in Physiology or Medicine with S. E. Luria and M. Delbrück for "for their discoveries concerning th…

1992 CE

#14268

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

Honjo discovered the programmed cell death protein 1 (PD-1). This discovery significantly contributed to the establishment of cancer immunotherapy principle by PD-1 blockade. Order of authorship in the original public…

1946 CE

#2578.5

Induced mutations in bacterial viruses.

Genetic recombination in bacteriophages. In 1969 Delbrück shared the Nobel Prize with A. D. Hershey and S. E. Luria "for their discoveries concerning the replication mechanism and the genetic structure of viruses."

2006 CE

#13287

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…

2017 CE

#10754

Infertility in early modern England.

1875 CE

#943.1

Influence de la pression de l’air sur la vie de l’homme. Climats d'altitude et climats du montagne. 2 vols.

Jourdanet’s observational work in remote areas of Latin America and Asia produced important evidence for Bert’s proof that altitude sickness is due to anoxemia. In La pression barométrique (No. 944)…

1708 CE

#581

Institutiones medicae in usus annuae exercitationis domesticos digestae.

Institutiones medicae, Boerhaave’s first book, represented lectures given by Boerhaave on June 23, 1701; it was soon being used in virtually every medical school in Europe, going though numerous authorized and u…

1629 CE–1631 CE

#11597

Integrum morborum mysterium, sive medicinæ catholicæ tomi primi tractatus secundus. [Pulsus seu nova et arcana pulsuum historia ... Hoc est, portionis tertiae pars tertia, de pulsuum scientia ... medicorum ... sive tomi primi tractatus secundi, sectio secunda, de morborum signis ... hoc est, divinatio per urinam.] In sectiones distributus duas : quorum ...

Fludd's Pulsus seu nova et arcana pulsuum historia contain's Fludd's chief medical writings. Dated 1629, but issued in this form, Fludd's Pulsus was the first published endorsement of Harvey's theory of the circulatio…

1957 CE

#13594

Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy.

Thomas and colleagues reported the first bone marrow transplants. They described the treatment of six patients with cancers and/leukemia and one patient with multiple myeloma. Three of the patients died, two responded…

1966 CE

#534.2

Investigations into generation, 1651-1828.

1874 CE

#1406.1

Investigations into the functions of the human brain.

Bartholow confirmed in man the findings of Fritsch and Hitzig (No. 1405) that electrical stimulus of the cortex on one side stimulated muscles on the other side of the body.

1958 CE

#2578.26

Iso-leuco-anticorps.

Discovery of the first histocompatibility antigen. In 1980 Dausset shared the Nobel Prize in Physiology or Medicine with B. Benacerraf and G. D. Snell "for their discoveries concerning genetically determined structure…

1989 CE

#12653

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

In this paper Houghton and colleagues named “hepatitis C” for the first time. They cloned and isolated the viral RNA genome and demonstrated that a patient who had high antibodies to a ‘native/wild s…

1983 CE

#12632

Ivermectin: A potent new antiparasitic agent.

Abstract "Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nemato…

1934 CE

#6622.1

John Keats’s anatomical and physiological note book …edited by Maurice Buxton Forman.

Keats was a pupil and dresser at Guy’s Hospital from 1815-16, and was licensed to practice upon completion of his studies. While struggling to launch his poetic career he was often tempted to practice medicine, …

2013 CE

#11582

Kenelm Digby's Two Treatises, edited with an introduction by Paul. S. MacDonald.

1890 CE–1930 CE

#4632

Klinische und anatomische Beiträge zur Pathologie des Gehirns. 8 pts. in 10 vols.

An important summary of the knowledge concerning aphasia appears in vols. 5-7.

1924 CE

#661

Körperstellung.

A classic work on muscle tone and posture, a subject upon which Magnus spent many years of study. He demonstrated among other things that the labyrinth is the one sense organ entirely concerned with posture and equili…

1888 CE

#1521

Kort öfversigt af läran om lokalisationen i hjernbarken.

Discovery of the cortical visual center.

1903 CE–1904 CE

#2003.2

L’électrisation cérébrale.

Leduc reported the effects of a galvanic current on the brain. His work led the way to electric convulsion therapy, introduced by Carletti and Bini (No. 4962).

1748 CE

#586

L’homme machine.

La Mettrie attempted among other things to prove the materialism of the soul. Because of his blatant and aggressive atheism, all of La Mettrie’s writings were placed on the Index and systematically burned. Owing…

1901 CE

#2555

L’immunité dans les maladies infectieuses.

A classic study of the mechanisms concerned in specific antibacterial immunity, and one of Metchnikoff’s best works. Russian edition: Nevospriimchivost’ k infekcionnim boleznyam. St. Petersburg: K.L. Rikke…

1881 CE

#783

La circulation du sang à l’état physiologique et dans les maladies.

1930 CE

#1169

La diabetes pancreática de los perros hipofisoprivos.

Houssay’s depancreatized hypophysectomized dog. This work led to Houssay’s demonstration of the importance of the anterior pituitary in sugar metabolism. See also Endocrinology, 1931,15, 511-23. In 1947 Ho…

1878 CE

#7294

La méthode graphique dans les sciences expérimentales et particulièrement en physiologie et en médecine.

Marey pioneered the use of graphical recording in the experimental sciences, using instruments (many of his own invention) to capture and display data impossible to observe with the senses alone, and to record the pro…

1899 CE

#838.1

La mort par les décharges électriques.

The first defibrillation. “Prévost and Battelli produced ventricular fibrillation in dogs by shocking with weak currents. They then shocked the fibrillating heart with a stronger current—the second,…

1884 CE

#10113

La paura.

Mosso conducted experiments with special equipment, which he devised to suit the requirements of the studies. He pursued two main lines of research: the analysis of motor functions and the relationship between physiol…

1878 CE

#944

La pression barométrique. Recherches de physiologie expérimentale.

The most famous work in the history of altitude physiology, in which Bert proved that the principal symptoms of altitude sickness arise from reduced partial pressure of oxygen and not from diminution of total pressure…

1875 CE

#496

Le maturation de l’oeuf, la fécondation et les premières phases du développement embryonnaire des mammifères.

First detailed description of the segmentation of the mammalian ovum.

1929 CE

#967

Le sinus carotidienet la zone homologue cardio-aortique.

In 1938 Heymans was awarded the Nobel Prize in Physiology or Medicine "for the discovery of the role played by the sinus and aortic mechanisms in the regulation of respiration."

1834 CE

#2748.2

Le sphygmomètre; instrument qui traduit à l’oeil toute l’action des artères.

Hérisson invented an instrument for recording blood pressure. Translated into English as The sphygmometer, an instrument which renders the action of the arteries apparent to the eye. A memoir... with an improve…

1899 CE

#1574.1

Le système nerveux centrale structure et fonctions. Histoire critique des théories et des doctrines. 2 vols.

Massive history of the anatomy and physiology of the nervous system from ancient Greece to the end of the 19th century, limited in its historical analysis. The second volume is a survey of end of 19th century opinions…

1891 CE

#638

Le travail musculaire et l’énergie qu’il représente.

Important studies on thermodynamics of muscular work.

1691 CE

#12692

Le vie de monsieur Descartes. [par Adrien Baillet].

An early separately published biography of a contributor to the history of the life sciences. Digital facsimile from Google Books at this link.

1855 CE–1856 CE

#615

Leçons de physiologie expérimentale appliquée à la médecine. 2 vols.

Claude Bernard made strenuous efforts to introduce experimental methods into physiology. The above includes his classic work on the function of the liver, pancreas, and gastric glands. Vol. 1, p. 126: Catheterization …

1879 CE

#634

Leçons de physiologie opératoire.

In this, his last work, Bernard showed himself “the unapproachable master in the technique of experimental procedure” (Garrison).

1857 CE–1881 CE

#12016

Leçons sur la physiologie et l'anatomie comparée de l'homme et des animaux faites a la Faculté des Sciences de Paris. 14 vols.

Digital facsimile of all the volumes from Google Books; vol. 1 at this link.

1858 CE

#1399

Leçons sur la physiologie et la pathologie du système nerveux. 2 vols.

1857 CE

#1863

Leçons sur les effets des substances toxiques et médicamenteuses.

Bernard included a summary of his experiments with curare in the Leçons to establish his priority in researching its effects. He demonstrated in these experiments the susceptibility of the nerve-muscle preparat…

1836 CE–1838 CE

#2217

Leçons sur les phénomènes physiques de la vie. 4 vols.

Magendie, pioneer experimental physiologist, regarded pathology as only a modification of physiology, “medicine the physiology of the sick man”. By him clinical medicine was reconstructed on physiological …

1575 CE

#284

Lectiones Gabrielis Falloppi de partibus similaribus humani corporis, ex diversis exemplari eus a Volchero Coiter summa cum diligentia collecta. His accessere diversorum animalium sceletorum explicationes iconibus artificiosis, et genuinis illustratae.

Coiter, a pupil of Fallopius and Eustachius, became town physician of Nuremberg. His book on comparative osteology, contained in his edition of the lectures of Fallopius, extended his studies begun in his work of 1572…

1928 CE–1941 CE

#1445

Lectures on conditioned reflexes. 2 vols.

Besides his work on digestion, Pavlov is remembered for his investigations upon conditioned reflexes. An English translation of another work by Pavlov, entitled Conditioned reflexes, appeared in 1927.

1839 CE

#2585

Lectures on the blood, and on the changes which it undergoes during disease: Delivered at the College of France in 1837-8.

Pp. 244-49: Magendie showed that secondary or subsequent injections of egg/albumin caused death in rabbits who had tolerated an initial injection. This was the first experiment in anaphylaxis, though Jenner in 1798 ha…

1901 CE

#1575

Lectures on the history of physiology.

Reprinted 1924 and (Dover Pubs.), 1970.