Facets

1999 CE–2000 CE

#9573

The works of Robert Boyle. Edited by Michael Hunter and Edward B. Davis. 14 vols.

1644 CE

#11858

Theatro d’Arcani del medico Lodovico Locatelli da Bergamo; nel quale si tratta dell’arte chimica, et suoi arcani, con gli afforismi d’Ippocrate commentati da Paracelso, et l’espositione d’alcune cifre, et caratteri oscuri de filosofi.

‘It is apparent that by the 1640’s Paracelsian medicine had gained momentum in Italy and that iatrochemical theories were being adopted by a number of Italian physicians. […] In 1644 there appeared …

2005 CE

#10270

Theophrast und Galen – Celsus und Paracelsus. Medizin, Naturphilosophie und Kirchenreform im Basler Buchdruck bis zum Dreissigjährigen Krieg. Publikationen der Universitätsbibliothek, Nr. 36. 4 vols. plus index vol.

"The project began as a exhibition in the Basle University Library to commemorate the major anniversaries of the birth and death of Paracelsus (1493–1541). Not only did he work and teach in Basle, but many of hi…

1847 CE

#6922

Thèses de physique et de chimie, Presentées à la Faculté des Sciences de Paris.

Pasteur reported a series of “investigations into the relation between optical activity, crystalline structure, and chemical composition in organic compounds, particularly tartaric and paratartaric acids. This w…

1975 CE

#14182

Three-dimensional model of purple membrane obtained by electron microscopy.

The invention of Cryogenic electron microscopy (cryo-EM). The novel technique was achieved by "by applying the method to tilted specimens, and using the principles put forward by De Rosier and Klug (GM - 13935), for t…

1950 CE

#3788.1

Triethylene melamine in the treatment of Hodgkin’s disease and allied neoplasms

With D. A. Karnofsky, J. H. Burchenal, and L. F. Craver.

1898 CE

#2266

Tropical diseases.

Manson has been called the “father of modern tropical medicine”. He had vast experience of disease in the Tropics and himself made many valuable contributions to the knowledge of this subject. He described…

1993 CE

#14341

Tuning the activity of an enzyme for unusual environments: Sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.

Arnold introduced a biochemical molecule manipulating technique to mimic the process of natural selection in creating new enzymes adapted to a specific catalytic reaction. She directed evolution of subtilisin E to obt…

1919 CE

#8795

Über die Anhalonium-Alkaloide I. Anhalin und Mezcalin

Synthesis of mescaline.

1863 CE

#1109

Ueber das Epithel der Lymphgefässwurzeln und über die von Recklinghausen’schen Saftcanälchen.

1876 CE

#700.1

Ueber das Verhalten verschiedener organisirter und sog. ungeformter Fermente (pp.191-193); Trypsin (Enzym des Pankreas) (pp.194-198).

Kühne was one of the people who introduced the term “enzyme”. He wrote, "Um Missverständnisse vorzubeugen und lästige Umschreibungen zu vermeiden schlägt Vortragender vor, die ungeformt…

1854 CE

#685.1

Ueber das Vorkommen von Leucin und Tyrosin in der menschlichen Leber.

Discovery of leucine and tyrosine in the urine.

1871 CE

#694

Ueber das Vorkommen von Urobilin im Darminhalt.

Discovery of urobilin in the intestines.

1890 CE

#715

Ueber den Einfluss der Alkalien auf den menschlichen Stoffwechsel.

1896 CE

#13046

Ueber den Einfluss des atmosphärischen Kohlensäuregehalts auf die Temperatur der Erdoberfläche.

Arrhenius used basic principles of physical chemistry to estimate the extent to which increases in atmospheric carbon dioxide are responsible for the Earth's increasing surface temperature, the "greenhouse effect."

1886 CE

#708

Ueber den Niederschlag, welchen Pikrinsäure in normalen Harn erzeugt und über eine neue Reaction des Kreatinins.

Jaffe’s creatinine test.

1877 CE

#697

Ueber die Ausscheidung des Indicans unter physiologischen und pathologischen Verhältnissen.

Isolation of indican in the urine.

1931 CE

#1195

Ueber die chemische Untersuchung der Sexualhormone.

The male sex hormone, androsterone, was isolated in crystalline form by Butenandt. In 1939 Butenandt received half of the Nobel Prize in Chemistry "for his work on sex hormones." The other half was awarded to Leopold …

1871 CE

#695

Ueber die chemische Zusammensetzung der Eiterzellen.

In 1869 Miescher discovered a substance which he termed nuclein (nucleoprotein), later shown to be the hereditary genetic material. He demonstrated it in pus cells. The discovery he first published in 1871. He was als…

1872 CE

#627

Ueber die Diffusion des Sauerstoffs, den Ort und die Gesetze der Oxydationsprocesse im thierischen Organismus.

1898 CE

#721

Ueber die Eiweissstoffe.

Kossel forecast the polypeptide nature of the protein molecule.

1849 CE

#682

Ueber die endosmotischen Aequivalent und die endosmotische Theorie.

In this development of his theory of urinary secretion (see No. 1232) Ludwig made important observations on endosmosis.

1928 CE

#750

Ueber die katalytischen Wirkungen der lebendigen Substanz.

1908 CE

#736

Ueber die kleinsten Moleküle, welche die Leber zur Synthese des Glykogenes verwerten kann.

1893 CE

#719

Ueber die Nucleinsaure.

See No. 702.

1832 CE

#1852

Ueber die Verbindungen, welche durch die Einwirkung des Chlors auf Alkohol, Aether, ölbildenes Gas und Essiggeist entstehen.

Discovery, in 1831, of chloroform and chloral. Independently chloroform was discovered by Souberian and by Guthrie.

1932 CE

#970

Ueber ein neues Oxydationsferment und sein Absorptionsspektrum.

1898 CE

#3776

Ueber eine eigenartige, unter dem Bilde der Pseudoleukämie verlaufende Tuberkulose des lymphatischen Apparates.

In his classic description of lymphadenoma, Sternberg separated it from aleukemic leukemia, with which it had hitherto been included.

1900 CE

#3779

Ueber eine hereditäre, unter dem Bilde eines chronischen Icterus mit Urobilinurie Splenomegalie, und Nierensiderosis verlaufende Affection.

“Minkowski–Chauffard disease”, familial hemolytic jaundice. See also No. 3781.

1884 CE

#704

Ueber eine neue linksdrehende Säure (Pseudooxybuttersäure).

Isolation of (ß-oxybutyric acid. (Title of second paper: Beiträge zur Kenntniss der activen ß-Oxybuttersäure).

1904 CE

#726

Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt.

Bohr, Hasselbalch, and Krogh showed, in the experimental animal, that the affinity of blood for oxygen depends upon carbon dioxide pressure. This became known as the Bohr effect, though the discovery may have been mad…

1853 CE

#685

Ueber einige Harnstoffverbindungen und eine neue Methode zur Bestimmung von Kochsalz und Harnstoff im Ham.

Liebig’s method of estimating urea.

1837 CE

#673

Ueber Knorpel und Knochen.

Isolation of chondrin and glutin.

1828 CE

#671

Ueber künstliche Bildung des Harnstoffs.

The synthetic preparation of urea was the first occasion that an organic compound was built up from inorganic materials. Wöhler’s discovery led eventually to the brilliant results that have been achieved in…

1893 CE

#2623

Ueber Lympho-Sarkomatosis.

Kundrat separated lymphosarcoma (“Kundrat’s disease”) from other malignant tumors involving the lymphatic system.

1885 CE–1886 CE

#705

Ueber Ptomaine. 3 vols.

Brieger isolated and determined the composition of a number of the ptomaines.

1878 CE

#633

Ueber Wärme und Oxydation der lebendigen Materie.

1929 CE

#969

Ueberden Absorptionsspektrum des Atmungsferments.

Warburg discovered the nature and function of the respiratory ferment. In 1931 Warburg was awarded the Nobel Prize in Physiology or Medicine "for discovery of the nature and mode of action of the respiratory enzyme."

1842 CE

#678

Umwandlung der Benzoësäure in Hippursäure im lebenden Organismus.

Discovery that benzoic acid taken in with food is excreted in the urine as hippuric acid. (But see the footnote to p. 474 of Garrison’s History of medicine, 1929.)

1776 CE

#668

Undersökning om blasestenen.

Discovery of uric acid. English translation in his Chemical Essays, London, 1786.

1848 CE

#681

Untersuchung der Ochsengalle.

1906 CE–1923 CE

#730

Untersuchungen über Aminosäuren, Polypeptide und Proteine. 2 vols.

In a series of papers, Fischer showed that animal and vegetable proteins are composed of a series of amino-acids united by elimination of water.

1859 CE

#620

Untersuchungen über Bewegungen und Veränderungen der contraktilen Substanz.

Proof of the coagulability of muscle proteins.

1861 CE

#1107

Untersuchungen über den Bau der Lymphdrüsen.

Histology of the lymphatics. His drew the illustrations.

1867 CE–1868 CE

#625

Untersuchungen über den Stoffwechsel der Muskeln, ausgehend vom Gaswechsel derselben. 3 vols.

Hermann’s views on nitrogen metabolism in muscular work correctly anticipated the later conclusions of Fletcher, Hopkins, and others.

1862 CE–1863 CE

#938

Untersuchungen über die Respiration.

The first combined feeding–respiration experiments. Pettenkofer and Voit devised an apparatus for their important experiments on respiration and metabolism. They were first to estimate the amounts of protein, fa…

1877 CE

#699

Untersuchungen über die Wirkung der Säuren auf den thierischen Organismus.

1653 CE

#1097

Vasa lymphatica.

Bartholin disputed the claim of Rudbeck as to priority in the discovery of the intestinal lymphatics. Although anticipated in this by Rudbeck, there is no doubt that Bartholinus was the first to appreciate the signifi…

1787 CE

#1104

Vasorum lymphaticorum corporis humani historia et ichnographia.

Mascagni, Professor of Anatomy at Siena, made several discoveries regarding the lymphatics. His beautiful atlas contained 41 engravings of the lymphatics and gained him lasting fame. He had previously published a Prod…

1837 CE

#674

Vorlaüfige Mittheilung betreffend Versuche über die Weingährung und Fäulniss.

Proof that putrefaction is produced by living bodies. Independently of Cagniard-Latour, Schwann discovered the yeast cell. He is regarded as the founder of the germ theory of putrefaction and fermentation.