Facets

1877 CE

#631

A text-book of physiology.

Foster was one of the greatest of the modern teachers of physiology. He became professor at Cambridge in 1883. Many great scientists are numbered among his pupils. See G.L. Geisen, Michael Foster and the Cambridge Sch…

1891 CE

#507

A theory of the structure of the placenta.

1910 CE

#2637

A transmissible avian neoplasm (sarcoma of the common fowl).

Original description of the chicken sarcoma (Rous sarcoma). Rous demonstrated that sarcomatous tumors in hens could be transmitted to normal hens by the injection of cell-free filtrates (virus) of the original tumor. …

1898 CE

#4629

A treatise on aphasia and other speech defects.

Bastian localized the auditory and visual centers, and he described word-blindness and word-deafness. (See also No. 4622.)

1880 CE–1881 CE

#500

A treatise on comparative embryology. 2 vols.

This work sums up all the previous knowledge on the subject, and includes Balfour’s own significant contributions. Balfour, a pupil of Michael Foster, became professor of animal morphology in 1882; in the same y…

1857 CE

#14187

A treatise on the cure of stammering, with a general account of the various systems for the cure of impediments in speech and a notice of the life of the late Thomas Hunt.

1846 CE

#11734

A treatise on the motive powers which produce the circulation of the blood.

The author was an American women's rights activist and educator rather than a physician or physiologist. Digital facsimile from U.S. National Library of Medicine at this link.

1809 CE

#1454

Abbildungen der menschlichen Organe des Geruches.

1806 CE

#1455

Abbildungen der menschlichen Organe des Geschmackes und der Stimme.

1832 CE–1833 CE

#480

Abhandlungen zur Bildungs-und Entwicklungs-Geschichte der Menschen und der Thiere. 2 pts.

Rathke’s most notable discovery was of structures homologous with gill slits in bird and mammalian embryos. He discredited the vertebral theory of the skull.

1945 CE

#14284

Acetylation of sulfanilamide by liver homogenates and extracts.

Discovery of co-enzyme A and its importance for intermediary metabolism. This discovery illuminated “the process by which cells make available the energy to drive their manufacturing processes” (Judson, p.…

1939 CE

#1310.1

Action potentials recorded from inside a nerve fibre.

Hodgkin and Huxley were the first to succeed in inserting electrodes into a living giant nerve fiber and to measure directly the action potential within it. In 1963 Hodgkin and Huxley shared the Nobel Prize in Physiol…

1937 CE

#1925

Action protectrice des éthers phénoliques au cours de l’intoxication histaminique.

First description of structure and action of an antihistamine. In 1957 Bovet was awarded the Nobel Prize in Physiology or Medicine “for his discoveries relating to synthetic compounds that inhibit the action of …

1960 CE

#12996

Acute pulmonary edema of high altitude.

Houston described four individuals who developed "edema of the lungs" as a result of high elevation activities. "He described chest X-rays with edema and non-specific changes on EKG. Even though these cases had been t…

1841 CE

#543

Allgemeine Anatomie. Lehre von den Mischungs- und Formbestandtheilen des menschlichen Körpers.

Many of the histological discoveries of Henle are described in the above. He classified tissues histologically. In the section on Gefässnerven (pp. 510, 690) Henle demonstrated the presence of smooth muscle in th…

1900 CE

#5945

Allgemeine Theorie der monochromatischen Aberrationen und ihre nächsten Ergebnisse für die Ophthalmologie.

The above work is the exposition of Gullstrand's general theory of monochromatic aberrations. This is an offprint from Nova Acta Reg. Soc. Sci. Ups., 1900-01, ser. 3, 20. In 1911 Gullstrand was awarded the Nobel Prize…

1667 CE

#916

An account of an experiment of preserving animals alive by blowing through their lungs with bellows.

By blowing air from a bellows over the exposed lungs of a dog, Hooke proved that respiratory motion is not necessary to maintain life, but that the essential feature of respiration lies in certain blood changes in the…

1708 CE

#11673

An account of animal secretion, the quantity of blood in the humane body, and muscular motion.

Keill applied measurement and mathematics in his researches, claiming the "first calculations of the absolute velocity at which blood travels through the aorta and smaller vessels; he also recognized that the blood's …

1738 CE

#584

An account of the bones of animals being changed to a red colour by aliment only.

Belchier fed animals with madder, noting that new bone formed subsequent to its ingestion was stained red. This was the earliest attempt at vital staining, and is also important as making possible the study of osteoge…

1803 CE

#1989.1

An account of the late improvements in galvanism…

Nephew of Galvani (see No. 593), Aldini developed and promoted animal electricity. His sensational experiments on the body of a criminal executed at Newgate, conducted with Carpue (No. 1989) were significant for the p…

1977 CE

#11043

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

Discovery of introns. In 1993 Roberts shared the Nobel Prize in Physiology or Medicine with Phillip A. Sharp "for their discoveries of split genes." It was frequently suggested that Chow deserved a share of that prize…

1935 CE

#858.1

An apparatus for the culture of whole organs.

In 1931, the year before his son’s sensational kidnapping, the celebrity aviator began working with Alexis Carrel at the Rockefeller Institute on a perfusion pump which would allow the cultivation of whole organ…

1895 CE

#8653

An atlas of the fertilization and karyokinesis of the ovum.

The first atlas of photomicrographs showing fertilization and cellular development during mitosis. The photomicrographs were taken by Leaming. Digital facsimile from the Internet Archive at this link.

1901 CE

#11180

An atlas of the medulla and midbrain: A laboratory manual.

1816 CE

#2742

An experimental inquiry into the nature, cause and varieties of the arterial pulse: And into certain other properties of the larger arteries, in animals with warm blood.

This work "included a summary of more than two dozen experiments he [Parry] conducted on a variety of mammals. In this book he discussed the pulsatile expansion of the arteries and importance of collaterals. Parry ref…

1724 CE

#12698

An impartial history of Michael Servetus, burnt alive at Geneva for heresie.

Authorship of this early English account of Servetus and his martyrdom for heresy has never been determined, according to Geoffrey Sill, "The authorship of An impartial history of Michael Servetus," Papers of the Bibl…

1815 CE

#765.2

An inquiry into the causes of the motion of the blood; with an appendix, in which the process of respiration and its connexion with the circulation of the blood are attempted to be elucidated.

Carson recognized the vital effect on venous return played by the negative pressure in the pleural cavity.

1834 CE

#12395

An inquiry into the claims of Doctor William Harvey to the discovery of the circulation of the blood; with a more equitable retrospect of that event. To which is added an introductory lecture delivered on the third of November, 18929, in vindication of Hippocrates from sundry charges of ignorance preferred against him by the late professor Rush.

Perhaps the earliest American monograph on the history of circulation. Keynes characterized this volume as "an elaborate and very learned attempt to belittle Harvey's achievement" Keynes, Life of William Harvey, p. 42…

1856 CE

#2079

Analyse physiologique des propriétés des systèmes musculaires et nerveux au moyen de curare.

Bernard paralysed motor nerve-endings with curare and demonstrated the independent excitability of muscle. He showed that curare acted by stopping the transmission of impulses from motor nerves to voluntary muscles.

1675 CE–1679 CE

#536

Anatome plantarum.

Malpighi was the founder of microscopic anatomy and a pioneer in the study of plant development. He approached the subject through the study of plant tissues. His Appendix adds to the work on chick embryology Malpighi…

1837 CE–1841 CE

#11697

Anatomia chirurgica truncorum arteriarum nec non fasciarum fibrosarum.

An atlas of arterial stems and fasciae. Translated into German as Chirurgische anatomie der Arterienstamme und Fascien neu Bearbeitet von Julius Szymanowski. Leipzig und Heidelberg: C. F. Winter, 1850. Digital facsimi…

1789 CE

#1453

Anatomicae disquisitiones de auditu et olfactu.

Scarpa made important researches concerning the auditory and olfactory apparatus of fishes, birds, reptiles, and man. See L. Sellers and B. Anson, [Scarpa’s] Anatomical observations on the round window, Arch. Ot…

1801 CE

#403

Anatomie générale, appliquée à la physiologie et à la médecine. 4 vols.

Bichat revolutionized descriptive anatomy. Where Morgagni and others had conceived of whole organs being diseased, Bichat showed how individual tissues could be separately affected. He covered tissue pathology, system…

1880 CE–1885 CE

#501

Anatomie menschlicher Embryonen. 3 pts. and atlas.

A systematic account of early human embryology that stimulated further investigation in a field in which His stood highest among his contemporaries. He was the first to study the human embryo as a whole.

1816 CE

#11178

Anatomie und Bildungsgeschichte des Gehirns im Foetus des Menschen: nebst einer vergleichenden Darstellung des Hirnbaues in den Thieren.

Digital facsimile from Universitätsbibliothek Heidelberg at this link.

1857 CE

#1462

Anatomie und Physiologie des menschlichen Stimm- und Sprach-Organs (Anthropophonik).

1874 CE

#493

Anthropogenie oder Entwicklungsgeschichte des Menschen.

1926 CE

#4633

Aphasia and kindred disorders of speech. 2 vols.

Head’s theory of aphasia conceived the condition as being “a disorder of symbolic formulation and expression”.

1866 CE

#4621.1

Aphasie, aphémie, alalie.

Includes a history of aphasia.

1863 CE

#816

Appareils et expériences cardiographiques.

First direct records of the heart impulse by means of a “cardiac sound” and the sphygmograph – recording tambours, which wrote on a moving drum covered with smoked paper.

2020 CE

#12627

Appetite and its discontents: Science, medicine, and the urge to eat, 1750-1850.

1614 CE

#573

Ars…de statica medicina aphorismorum sectionibus septem comprehensa.

This collection of aphorisms is the work by which Santorio’s ideas became widely known. Santorio used a beam balance to measure metabolism. See also nos. 572.1 & 572.2. For description of his experiments, see No…

1927 CE

#251.1

Artificial transmutation of the gene.

Muller showed that radiation causes mutations that are passed on from one generation to the next. This was the first suggestion that inherited traits might be altered or controlled, and it created a sensation: “…

1853 CE

#684

Atlas der physiologischen Chemie.

1970 CE

#12321

Australia antigen (a hepatitis-associated antigen). Purification and physical properties.

Purification of the Australia antigen and investigation of its physical properties. (Order of authorship in the original publication: Millman, Loeb, Bayer, Blumberg.) Blumberg shared the 1976 Nobel Prize in Physiology…

2005 CE

#14257

Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.

Südhof is credited with discovering much of the machinery mediating neurotransmitter release and presynaptic plasticity, beginning with the discovery of symaptotagmins and their role in neurostrasmitter release f…

1979 CE

#12631

Avermectins, new family of potent anthelminthic agents, efficacy of the B1a component.

Campbell and colleagues reported unprecedented antiparasitic effects of the agent in vivo, and that the "B1a" component of the molecule was most effective as a single oral dose. (Order of authorship in the original pu…

1979 CE

#12630

Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation.

The authors, lead by Omura, announced the discovery of Streptomyces avermilitis. They described the structure of avermectin, and reported preliminary observations that this drug is antiparasitic. (Order of authorship …

1943 CE

#12192

Barometric pressure: Researches in experimental physiology. Translated from the French by Mary Alice Hitchcock and Fred A. Hitchcock. [Foreward by John F. Fulton].

Digital facsimile from the Internet Archive at this link.

1888 CE

#505

Beiträge zur Entwickelungsmechanik des Embryo. Ueber die künstliche Hervorbringung halber Embryonen durch Zerstörung einer der beiden ersten Furchungskugeln, sowie über die Nachentwickelung (Postgeneration) der fehlenden Körperhalfte.

Roux is regarded as the founder of developmental mechanics (“Entwicklungsmechanik” as he named it). His work on the production of half-embryos initiated a turning point by shifting emphasis from descriptiv…