Facets

1952 CE

#12032

A nonhereditary, host-induced variation of bacterial viruses.

Order of authorship in the original publication: Luria, Human. Luria and Human discovered the restriction modification system found in bacteria and other prokaryotic organisms. This system provides a defense against f…

1929 CE

#3202.1

A note on the inhalation treatment of asthma.

First use of adrenaline by the respiratory route for the treatment of bronchial asthma.

1983 CE

#12663

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions,

Zur Hausen and colleageus identified HPV 16 DNA in cervical cancer tumors by Southern blot hybridization. Digital facsimile from PubMedCentral at this link.

1896 CE

#4123

A peculiar affection of the mucous membrane of the lips and the oral cavity.

Fordyce, remembered for the description of “Fox–Fordyce disease”, also described a pseudocolloid of the buccal mucosa, which is known as “Fordyce’s disease”.

1861 CE

#4052

A peculiar atrophy of the skin (Lineae atrophicae).

First description of lineae atrophicae.

1901 CE

#4134

A peculiar progressive pigmentary disease of the skin.

Schamberg’s progressive pigmentary dermatosis; first description.

1936 CE

#1151

A physiologic and chemical investigation of the suprarenal cortex.

Isolation of nine closely related steroid hormones from adrenal cortical extracts; one of these was Compound E (C21H28O5) which in 1939 was renamed cortisone. With H. L. Mason, C. S. Myers, and W. D. Allers. See also …

1797 CE

#11491

A practical inquiry into disordered respiration, distinguishing the species of convulsive asthma, their causes, and indications of cure,

Bree "embodied the numerous experiments in his own case, gave a more full and complete view of asthma and dyspnœa than had hitherto appeared, and laid down some important therapeutic rules, the practical value o…

1813 CE

#4021

A practical synopsis of cutaneous diseases according to the arrangement of Dr. Willan.

This was the most influential textbook of dermatology of the 19th century, and the work which conveyed Willan’s system to most of the medical world. Included in the book was material by Willan which remained unp…

1891 CE

#10598

A practical treatise on diseases of the skin

The first systematic treatise on dermatology published in America. Piffard was a pioneer of "indoor" magnesium flashlight photography, and took most of the 50 photographs reproduced in this book by this technique. Dig…

1845 CE

#6036

A practical treatise on inflammation, ulceration, and induration of the neck of the uterus.

Bennet was the first to differentiate between benign and malignant uterine tumors.

1860 CE

#3459.1

A practical treatise on the aetiology, pathology, and treatment of the congenital malformations of the rectum and anus.

The first systematic treatise on the subject, and a landmark in pediatric surgery. Includes an early account of colostomy and one of the earliest histories of that procedure. Digital facsimile from the Hathi Trust at …

1824 CE

#11156

A practical treatise on the diseases of the skin, comprehending an account of such facts as have been recorded on these subjects, with original observations. The whole arranged with a view to illustrate the constitutional causes of these diseases, as well as their local characters.

Plumbe was one of the most outspoken critics of Willan and Bateman’s morphological system of skin disease classification. In his Practical Treatise he was the first dermatologist to attempt to produce a classifi…

1901 CE

#1147

A preliminary report on the active principle of the suprarenal gland.

Independently of Takamine, Aldrich succeeded in isolating adrenaline in a crystalline form. He gave it the formula C9H13NO3. Adrenaline was the first hormone to be isolated.

1920 CE

#2645.1

A preliminary report on the experimental production of sarcoma of the liver of rats.

Proof that cancer can be caused by a parasite, Cysticercus fasciolaris, the larval stage of Taenia crassicolis. With M. R. Curtis and G. L. Rohdenberg. See also Proc. N.Y. path. Soc., 1920, 20, 149-75.

1940 CE

#9483

A preliminary report on the use of fast neutrons in the treatment of malignant disease.

First report on the introduction of neutron therapy for cancer. See Hans Svensson & Torsten Landberg, "Neutron therapy--the historical background," Acta Oncologica, 33:3 (1984) 227-231. In 1938 Stone began clinical tr…

1800 CE–1802 CE

#5424

A prospect of exterminating the small-pox, being the history of the variolae vaccinae, or kine-pox, commonly called the cow-pox; as it has appeared in England: With an account of a series of inoculations performed for the kine-pox in Massachusetts. [Part II:] A prospect of exterminating the small pox part II, being a continuation of a narrative of facts concerning the progress of the new inoculation in America; together with practical observations on the local appearance, symptoms, and mode of treating the variola vaccina, or kine pock; including some letters to the author, from distinguished characters, on the subject of this benign remedy, now passing with a rapid step through all ranks of society in Europe and America.

Waterhouse introduced Jennerian vaccination into the U.S.A. He vaccinated his own child as his first case. See J. B. Blake, Benjamin Waterhouse and the introduction of vaccination. A reappraisal. Philadelphia, 1957. D…

1935 CE

#2576.3

A protective action of neurotropic against viscerotropic yellow fever virus in Macacus rhesus.

One of the first examples of an animal virus interference phenomenon was demonstrated by Hoskins.

1929 CE

#2576.01

A quantitative study of the precipitin reaction between Type III pneumococcus polysaccharide and purified homologous antibody.

Heidelberger and Kendall adapted the precipitin reaction to permit the quantitative measurement of antibody and antigen. This established the principle of quantitative immunochemistry.

1889 CE–1890 CE

#4098

A rare form of lupus (marginatus).

“Hilliard’s lupus”. Hutchinson made an innovation in terminology when he named the disease after the patient instead of the physician describing it. The Archives, which ran to 11 volumes, were writte…

1884 CE

#3834

A recent specimen of artificial myxoedema in a monkey.

By experimental removal of the thyroid Horsley produced artificial myxedema, confirming previous work by Reverdin and others. At the time his results were regarded as proof that total thyroidectomy produces operative …

1958 CE–1959 CE

#2660.12

A sarcoma involving the jaws in African children.

Burkitt’s lymphoma (African lymphoma), first described in detail by Sir Albert Cook, a medical missionary, but not published by him.

1924 CE

#5083

A scarlet fever antitoxin.

Following their successful attempts to establish individual susceptibility to scarlet fever, these workers prepared an antitoxin for immunization.

1950 CE

#2660.2

A sensitive directional gamma-ray detector.

Directional scintillation detector probe. Cassen assembled the first automated scanning system, comprised of a motor driven scintillation detector coupled to a relay printer. The scanner was initially used to image th…

1983 CE

#7871

A short history of breast cancer.

1830 CE

#2611

A short tract on the formation of tumours, and the peculiarities that are met with in the structure of those that have become cancerous; with their mode of treatment.

Contains the first illustrations of microscopic sections of cancer; however, Home drew no worthwhile conclusion from his microscopic studies. Digital facsimile from the Internet Archive at this link.

1963 CE

#3924.4

A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants.

Bacterial inhibition test for phenylketonuria.

1788 CE

#3929

A singular case of diabetes, consisting entirely in the quality of the urine; with an inquiry into the different theories of that disease.

Cawley was the first to suggest a relationship between the pancreas and diabetes, observing that the disease may follow injury to that organ.

1994 CE

#14015

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Discovery of the BRCA1 gene using the technique of restriction fragment length polymorphism (RFLP). (Thanks to Juan Weiss for this reference and its interpretation.)

1939 CE

#5087.2

A study in active immunization against pertussis.

Pertussis vaccine.

1901 CE

#3866

A study of congenital sarcoma of the liver and suprarenal. With report of a case.

Pepper’s type of adrenal medullary tumor.

1907 CE–1908 CE

#2633

A study of heredity in relation to the development of tumours in mice.

First experimental study of the heredity of mouse cancer.

1915 CE

#11015

A study of prolonged fasting.

Study of a subject who was allowed to drink water but ingested no food for 31 days. Digital facsimile from the Internet Archive at this link.

1906 CE

#5531.1

A study of some tropical ulcerations of skin with particular reference to their etiology.

Strong described organisms consistent with Histoplasma capsulatum before Darling, although his work was overshadowed by the latter.

1906 CE

#2595

A study of the cause of sudden death following the injection of horse serum.

Forms Bulletin No. 29 of the Hygienic Laboratory, U. S. Marine Hospital Service. Rosenau and Anderson drew attention to the fact that animals receiving an injection of a foreign protein became sensitive to a second do…

1888 CE–1889 CE

#3917

A subcutaneous connective tissue dystrophy of the arms and back, associated with symptoms resembling myxoedema.

First description of adiposis dolorosa (“Dercum’s disease”).

1938 CE

#3801.1

A syndrome of infantilism, congenital webbed neck, and cubitus valgus.

“Turner’s syndrome”.

1845 CE

#3991.1

A synopsis of the symptoms, diagnosis, and treatment of the more common and important diseases of the skin.

First comprehensive American work on dermatology.

1954 CE

#1175.4

A synthetic preparation possessing biological properties associated with arginine-vasopressin.

Synthesis of vasopressin. With D. T. Gish and P. G. Katsoyannis.

1919 CE

#3922

A system of blood analysis.

Folin–Wu test for blood sugar.

1945 CE

#3869

A tentative test for pheochromocytoma.

The Roth–Kvale histamine test for the diagnosis of pheochromocytoma.

1910 CE

#2637

A transmissible avian neoplasm (sarcoma of the common fowl).

Original description of the chicken sarcoma (Rous sarcoma). Rous demonstrated that sarcomatous tumors in hens could be transmitted to normal hens by the injection of cell-free filtrates (virus) of the original tumor. …

1932 CE

#2656

A transmissible tumor-like condition in rabbits.

Shope papilloma virus (SPV), a benign infectious tumor due to a virus. This was the first mammalian tumor virus discovered. Full text from PubMedCentral at this link. See also Shope, "Infectious Papillomatosis of Rabb…

1698 CE

#3166

A treatise of the asthma.

Floyer provided the first clear descriptions of cases of bronchial asthma. Floyer himself suffered from asthma for over 30 years. He recognized the influence of heredity in asthma. The above includes (p. 239) an impor…

1784 CE

#2734.4

A treatise on the diseases of children.

Underwood laid the foundation of modern pediatrics. His work was superior to anything that had previously appeared and remained the most important book on the subject for sixty years, passing through many editions. Th…

1849 CE

#4529

A treatise on the pathology, diagnosis, and treatment of neuroma.

Smith’s large and beautifully illustrated atlas contains the first clear description and illustration of neurofibromatosis, published 33 years before von Recklinghausen’s account of the disorder (see No. 4…

1883 CE

#3831

A typical case of myxoedema.

Semon argued that cachexia strumipriva, myxedema, and cretinism were all due to loss of function of the thyroid. His contention, at first criticized, was later fully endorsed by the report of a committee set up by the…

1958 CE

#4154.6

A unique case of trichorrhexis nodosa – “bamboo hairs”.

“Netherton’s syndrome”.

2011 CE

#11052

A woman's disease: A history of cervical cancer.

1928 CE

#5461

A yellow fever vaccine.

First vaccine for immunization against yellow fever. Hindle devised a method for the transportation of frozen infected material from West Africa to London, making it possible to carry on experimental work in Britain.