Facets

1944 CE

#2659.2

“Folic acid” a tumor growth inhibitor.

Inhibition of tumor growth by a folic acid concentrate. With R. Lewisohn, D. Laszlo. These workers later (Proc. Soc. exp. Biol. N. Y., 1944, 56, 144-45) obtained similar results with xanthopterin.

1953 CE

#1138.1

3:5:3'-Triiodothyronine. I. Isolation from thyroid gland and synthesis.

Discovery of the second thyroid hormone, triiodothyronine. Digital facsimile from PubMedCentral at this link.

1926 CE

#5782.1

A further report on cancer of the breast, with special reference to its associated antecedent conditions.

First modern case-control study.

1988 CE

#10452

A history of the Imperial Cancer Research Fund 1902-1986.

"The author takes a broad perspective and provides a comparative framework by discussing the changing relationship between the ICRF and the medical profession, government, and other charities, notably the Cancer Resea…

1934 CE

#5045

A new antigen of B. typhosus. Its relation to virulence and to active and passive immunisation.

Vi antigens first described.

1932 CE

#3923.1

A new error of tyrosine metabolism: tyrosinosis, intermediary metabolism of tyrosine and phenylalanine.

1935 CE

#2576.3

A protective action of neurotropic against viscerotropic yellow fever virus in Macacus rhesus.

One of the first examples of an animal virus interference phenomenon was demonstrated by Hoskins.

1924 CE

#5083

A scarlet fever antitoxin.

Following their successful attempts to establish individual susceptibility to scarlet fever, these workers prepared an antitoxin for immunization.

1963 CE

#3924.4

A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants.

Bacterial inhibition test for phenylketonuria.

1939 CE

#5087.2

A study in active immunization against pertussis.

Pertussis vaccine.

1945 CE

#3869

A tentative test for pheochromocytoma.

The Roth–Kvale histamine test for the diagnosis of pheochromocytoma.

2011 CE

#11052

A woman's disease: A history of cervical cancer.

1937 CE

#1925

Action protectrice des éthers phénoliques au cours de l’intoxication histaminique.

First description of structure and action of an antihistamine. In 1957 Bovet was awarded the Nobel Prize in Physiology or Medicine “for his discoveries relating to synthetic compounds that inhibit the action of …

1943 CE

#1174

Adrenocorticotropic hormone.

Choh Hao Li and colleagues Isolated pure adrenocorticotropic hormone (ACTH) from sheep pituitary glands.

1905 CE–1906 CE

#1180

An experimental enquiry into the factors which determine the growth and activity of the mammary glands.

In their classic paper on the mammary gland, these workers attributed its changes during pregnancy to the fetus.

1968 CE

#3108.9

Arabinosyl cytosine: A useful agent in the treatment of acute leukemia in adults.

Cytosine arabinoside. With J. P. Holland, M. Weil, et al.

1928 CE

#2652

Cancer and heredity.

By selective breeding over a period of 15 years, Slye produced generations of mice absolutely resistant to, or particularly susceptible to, cancer. She demonstrated that resistance is a Mendelian dominant and suscepti…

2014 CE

#11346

Cancer virus: The story of Epstein-Barr virus.

2017 CE

#10555

Cancer, radiation therapy, and the market.

2003 CE

#10709

Conjoined twins: An historical, biological and ethical issues encyclopedia.

2007 CE

#11843

CRISPR provides acquired resistance against viruses in prokaryotes.

Horvath and his team provided key details of the extremely complex mechanisms involved in CRISPR's function as an immune system for bacteria against bacteriophages. Analogous to Pasteur's heroic role in saving the Fre…

1964 CE

#2660.17

Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma.

Order of authorship in the original publication: Epstein, Barr. Discovery of the Epstein-Barr virus, a human herpes virus causing infectious mononucleosis, and implicated in Burkitt’s lymphoma and other forms of…

1907 CE

#2596

De l’anaphylaxie et de l’anti-anaphylaxie vis-à-vis du sérum de cheval.

“Anti-anaphylaxis” was the term given by Besredka and Steinhardt to the specific desensitization of sensitized animals.

1956 CE

#2353.1

Freeze-dried B.C.G. vaccination of newborn infants with a British vaccine.

Freeze-dried B.C.G. vaccine.

1916 CE

#2642

Further investigations on the origin of tumours in mice. III. On the part played by internal secretion in the spontaneous development of tumours.

Demonstration of the influence of an internal secretion on the development of spontaneous cancer. Castration of female mice of a strain in which mammary cancer was frequent reduced its incidence and delayed its growth.

2015 CE

#11848

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.

Order of authorship in the original publication: Whitworth, Rowland, Ewen, ... Prather. Using the CRISPR Cas molecular gene-editing tool, Prather and colleagues edited the gene that codes for the CD163 protein in adul…

1931 CE

#4670.5

Immunological differences between strains of poliomyelitis virus.

1960 CE

#2578.28

Immunosassay of endogenous plasma insulin in man.

First radioimmunoassay of a hormone, a test capable of estimating nonogram or even picogram quantities. In 1977 Yalow received half of the Nobel Prize in Physiology or Medicine "for the development of radioimmunoassay…

1940 CE

#1173.1

Interstitial cell stimulating hormone. II. Method of preparation and some physico-chemical studies.

Choh Hao Li and colleagues isolated of the interstitial cell stimulating (luteinizing) hormone.

1945 CE

#1175.1

Isolation and properties of the anterior hypophyseal growth hormone.

Choh Hao Li and colleagues isolated the anterior pituitary growth hormone.

1949 CE

#1175.2

Isolation of pituitary follicle-stimulating hormone (FSH).

By Choh Hao Li and colleagues.

2019 CE

#10913

Kaposi sarcoma in mantled guereza.

Order of authorship in original publication: Grewer, Bleyer, Matz-Rensing. Further work on the CBGHV1 (Colobine gammherpesvirus 1) which causes a pathology in the Colobus monkey very similar to that seen humans. (Than…

1995 CE

#10914

Kaposi's Sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.

Chang, Moore and colleagues showed that the virus causing Kaposi's Sarcoma also causes body cavity lymphomas and lymphomatous effusions in humans. (Thanks to Juan Weiss for this reference and its interpretation.)

1946 CE

#3106

Leukaemia treated with urethane compared with deep x-ray therapy.

Urethane in treatment of leukemia. With A. Haddow, I. Ap Thomas, and J. M. Watkinson.

1957 CE

#2578.23

Leukocyte agglutinins in human sera. Correlations between blood transfusions and their development.

Leucocyte typing.

1948 CE

#4154.1

Melanomas of childhood.

Spitz first defined the histologic criteria for the diagnosis of juvenile melanoma.

1942 CE

#2700.01

Metabolic studies on neoplasm of bone with the aid of radioactive strontium.

Radioisotopic bone scanning. With B. Low-Beer, H. Friedell, and J. Lawrence.

1906 CE

#3959

Morphology and physiology of areas of Langerhans in some vertebrates

Lydia De Witt ligated the pancreatic ducts and obtained extracts from the islets of Langerhans in cats, noting their glycolytic qualities.

2019 CE

#10912

Novel virus related to Kaposi's Sarcoma associated herpesvirus from Colobus monkey.

Discovery of a new Karposi's Sarcoma virus in monkeys, named CbGHV1. Autopsy showed that the monkey died from a "primary effusion lymphoma" similar to the deaths of humans from human Karposi Sarcoma virus. (Thanks to …

1902 CE

#3780

On the pathological changes in Hodgkin’s disease, with especial reference to its relation to tuberculosis.

Dorothy Reed’s classic work on Hodgkin’s disease included a study of the histological picture. She described the proliferation of the endothelial and reticular cells, and the formation of lymphadenoma cell…

1942 CE

#2578.2

Pneumococcus polysaccharide as a paralyzing agent on the mechanism of immunity in white mice.

1994 CE

#7066

Positional cloning of the mouse obese gene and its human homologue.

Discovery of the hormone leptin and its role in regulating body weight. Friedman and associates subsequently found that injections of the encoded protein, leptin, decrease body weight of mice by reducing food intake a…

1939 CE

#6231

Prediction and prevention of late pregnancy accidents in diabetes.

First report of hormone treatment. Written with R.S. Titus, E.P. Joslin, and H. Hunt.

1956 CE

#7782

Preliminary communication: Malignant disease in childhood and diagnostic irradiation in-utero.

Stewart was one of the earliest to study the effect of prenatal X-rays, later replaced by ultrasound. She found that the children of mothers who received these X-rays were almost twice as likely to develop leukemia or…

1936 CE

#5484.2

Propagation of rabies virus in tissue culture and the successful use of culture virus as antirabic vaccine.

Webster and Clow succeeded in growing rabies virus in tissue culture.

1938 CE

#2576.7

Recherches sur le phénomène de Twort-d’Hérelle (bactériophage ou autolyse hérédo-contagieuse).

The Wollmans made important contributions to the knowledge on bacteriophage and lysogeny.

1942 CE

#2578.1

Sensitization to horse serum by means of adjuvants.

Freund’s adjuvant. Freund’s procedure allowed adjuvants to be used for any antigen.

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1898 CE

#2003

Sur une substance nouvelle radio-active, contenue dans la pechblende.

The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…

1941 CE

#2578

The absorption of influenza virus by red cells and a new in vitro method of measuring antibodies for influenza virus.

Independently of Hirst, McClelland and Hare discovered virus hemagglutination.