Facets

1971 CE

#13958

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

In 1982 Vane shared the Nobel Prize in Physiology or Medicine with Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances."

1937 CE

#1925

Action protectrice des éthers phénoliques au cours de l’intoxication histaminique.

First description of structure and action of an antihistamine. In 1957 Bovet was awarded the Nobel Prize in Physiology or Medicine “for his discoveries relating to synthetic compounds that inhibit the action of …

1953 CE

#2660.4

Aryl-2-halogenoalkylamines. Part XII. Some carboxylic derivatives of NN-Di 2-chloroethylaniline.

Chlorambucil (a nitrogen mustard) used in the chemotherapy of cancer. With J. R. Roberts and W. J. C. Ross.

1955 CE

#2660.8

Carcinolytic action of antibiotics: puromycin and actinomycin.

1761 CE

#2607.1

Cautions against the immoderate use of snuff. Founded on the known qualities of the tobacco Plant; and the effects it must produce when this way taken Into the body: And by instances of persons who have perished miserably of diseases, occasioned, or rendered incurable by its use,

First clinical report (pp. 30-31) of an association between tobacco and cancer, in this case “polypusses” of the nose caused by taking snuff. Hill was a distinguished botanist and apothecary, although rega…

1956 CE–1960 CE

#86.4

Collected papers of Paul Ehrlich. Compiled and edited by F. Himmelweit. 3 vols.

Vol. I: Histology, biochemistry, and pathology, Vol. 2: Immunology and cancer research; Vol. 3: Chemotherapy. Most texts are in German. English translations are also published when available. The set includes new Engl…

1970 CE

#2660.24

Combination chemotherapy in the treatment of advanced Hodgkin’s disease.

Combination chemotherapy with nitrogen mustard (mustine hydrochloride), vincristine sulphate, procarbazine hydrochloride and prednisone, introduced in 1964 for the treatment of advanced Hodgkin’s disease. With A…

1975 CE

#2578.43

Continuous cultures of fused cells secreting antibody of predefined specificity.

Hybridomas. In 1984 Köhler and Milstein shared the Nobel Prize in Physiology or Medicine with Niels K. Jerne, "for theories concerning the specificity in development and control of the immune system and the disco…

1930 CE

#3973

Contribución al estudio sobre la composición quimica de la insulina. Estudio de algunos cuerpos sintéticos solfurados con acción hypoglucemiante.

Discovery of the hypoglycemic effect of certain sulphonamide derivatives. With L. L. Silva and L. Libenson.

1894 CE

#2107

Contribution à l’étude du vénin des serpents.

Calmette carried out extensive investigations on the immunization of animals to venoms. He obtained antivenom sera with therapeutic properties.

1954 CE

#2660.7

Cytoactive amino-acid and peptide derivatives. I. Substituted phenylalanines.

Melphalan (a nitrogen mustard) later used in the chemotherapy of cancer.

1902 CE

#2590

De l’action anaphylactique de certains venins.

First full description of the phenomenon of “anaphylaxis,” the name of which was coined by Richet. Abbreviated English translation in Bibel, Milestones of immunology (1988). In 1913, Richet was awarded the…

1795 CE

#2609.1

De morbis vasorum absorbentium corporis humani.

Soemmerring noted an association between pipe smoking and cancer of the lip (p. 109).

1897 CE

#2002

Demonstration eines mit Röntgenstrahlen behandelten Falles von Naevus pigmentosus pilosus.

First use of x rays for deep irradiation therapy.

1929 CE–1934 CE

#1125

Die Hormone; ihre Physiologie und Pharmakologie. 2 vols.

1684 CE

#1311

Dr. Willis's practice of physick.

The only complete edition of Willis's works in English, translated by the poet Samuel Pordage. It contains the translations of all his works except his Affectionum quae dicuntur hystericae (1671). The collection inclu…

1926 CE

#5289

Essai de prophylaxie des trypanosomiases par des dérivés phénylarsiniques administré

First attempt to induce prophylaxis by chemical means in trypanosomiasis. With S. Nicolau and I. Galloway.

1963 CE

#2660.14

Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects.

1958 CE

#4011.1

Experimental ringworm in guinea pigs: oral treatment with griseofulvin.

Use of griseofulvin in the treatment of ringworm.

1932 CE–1934 CE

#1921

Handbuch der Chemotherapie. 2 vols.

1929 CE

#2576.02

Hypersensitiveness to arsphenamine in guinea pigs. I. Experiments in prevention and desensitization.

First demonstration of specific, acquired, lasting refractoriness to sensitization. This is the same or a closely related phenomenon to that demonstrated later by Burnet and Medawar under the name immune tolerance. Se…

1886 CE

#1883

Ichthyol und Resorcin als Repräsentanten der Gruppe reduzierender Heilmittel.

Unna introduced ichthyol and resorcinol into medicine. Supplement to Mh. prakt. Derm., No. 1.

1949 CE

#3855.1

Imidazoles. IV. The synthesis and antithyroid activity of some 1-substituted-2-mercaptoimidazoles.

Synthesis of methimazole (mercazole, thiamazole), an antithyroid drug more potent than methylthiouracil. With E. C. Kornfeld, K. C. McLaughlin, and R. C. Anderson.

1952 CE

#7764

Incidence of leukemia in survivors of the atom bomb in Hiroshima and Nagasaki, Japan.

Leukemia was the first cancer to be linked with radiation exposure in atomic bomb survivors.

1944 CE

#2659.3

Influence of synthetic oestrogens upon advanced malignant disease.

Administration of synthetic estrogens in advanced mammary cancer caused regression of tumors. With J. M. Watkinson, E. Paterson, and P. C. Koller.

1906 CE

#2005

Interprétation de quelques résultats de la radiothérapie et essai de fixation d’une technique rationelle.

Bergonié-Tribondeau law, “the sensitivity of cells to radiation varies directly with the reproductive capacity of the cells and inversely with their degree of differentiation” (Dorland).

1490 CE

#47

Liber Teisir, sive rectificatio medicationis et regiminis. Antidotarium. Translated from Arabic into Hebrew by Jacobus Hebraeus; into Latin by Paravicius. Add: Averroes: Colliget.

This is a Latin translation from a Hebrew version dating from 1280. Avenzoar, the greatest Muslim physician of the Western Caliphate, described the itch-mite, Sarcoptes scabiei, serous pericarditis, mediastinal absces…

1970 CE

#7761

Low dose radiation and cancer.

This paper, delivered at the 1969 Nuclear Science Symposium and Nuclear Power Systems Engineering Symposium, October, 1969, provided powerful scientific evidence that the then currently allowable radiation dose (Feder…

2019 CE

#11482

Mapping human microbiome drug metabolism by gut bacteria and their genes.

Order of authorship in the original publication: Zimmermann, Simmerman-Kogadeeva, Wegmann....The authors looked at 271 drugs and 68 different species from the main taxonomic microbiome groups. Of the 271 drugs, 176 un…

1991 CE

#8650

Milestones in leukemia research and therapy.

Freireich was part of the team that first introduced combined-drug cancer chemotherapy in 1965.

1956 CE

#1947.3

Mitomycin, a new antibiotic from streptomyces.

Isolation of mitomycin C, effective in Hodgkin’s disease and lymphoma. With six co-authors.

1965 CE

#7790

Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis.

1958 CE

#2660.11

Neuartige Krebs-Chemotherapeutica aus der Gruppe der zyklischen N-Lost-Phosphamidester.

Cyclophosphamide. With F. Bourseaux and N. Brock.

1946 CE

#10133

Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.

Widely considered the first uses of chemotherapy for the treatment of malignant diseases.

1818 CE

#10069

Oeuvres complètes de Bordeu, précédés d'une notice sur sa vie et sur ses ouvrages, par M. le Chevalier Richerand. 2 vols.

1867 CE

#1996.3

On the electrolytic treatment of tumors, and other surgical diseases.

Althaus introduced Duchenne’s methods into England. He was the first to employ electrolysis for medical purposes. Greatly expanded third edition, 1873.

1895 CE

#2108

On the rendering of animals immune against the venom of the cobra and other serpents; and on the antidotal properties of the blood serum of the immunised animals.

Fraser investigated the possibilities of immunization against cobra venom and obtained “antivenene”, an antivenom serum.

1878 CE

#4075.1

On the treatment of psoriasis by an ointment of chrysophanic acid.

Introduction of chrysarobin in dermatology.

1820 CE

#2073

Pharmacologia; or the history of medicinal substances, with a view to establish the art of prescribing. 3rd ed.

First description of cancer caused by arsenic (p. 133).

1957 CE

#3978.3

Pharmacological studies of a new oral hypoglycemic drug.

Phenformin, a biguanide formerly used in diabetes. With L. Freedman and S. L. Shapiro. Clinical report on pp. 193-4.

1956 CE

#7782

Preliminary communication: Malignant disease in childhood and diagnostic irradiation in-utero.

Stewart was one of the earliest to study the effect of prenatal X-rays, later replaced by ultrasound. She found that the children of mothers who received these X-rays were almost twice as likely to develop leukemia or…

1936 CE

#3974

Protamine insulinate.

Hagedorn created NPH insulin and founded Nordisk Insulinlaboratorium, known today as Novo Nordisk. NPH insulin is one of the earliest examples of engineering drug delivery. Hagedorn became interested in modifying the …

1981 CE

#7760

Radiation and human health.

The first comprehensive book summarizing the evidence relating low-level ionizing radiation to cancer and other diseases.

1970 CE

#7783

Radiation dose effects in relation to obstetric X-rays and childhood cancers.

In this study of ten million children Stewart and Kneale showed that obstetric X-rays significantly increased the rate of childhood leukemia and cancer.

1950 CE

#3215.2

Smoking and carcinoma of the lung. Preliminary report.

A study of 1,465 cases of lung cancer and 1,465 matched controls, which confirmed and extended the studies of Wynder and Graham, and others. See also later papers by the same authors in Brit. med. J., 1952, 2,1271-86;…

1964 CE

#7385

Smoking and health: report of the Advisory Committee to the Surgeon General of the Public Health Service.

Definitive 386-page throughly documented study of the carcinogenic and pulmonologic effects of smoking, and the addictive aspects of nicotine. It was published under the supervision of Surgeon-General Luther Terry. Di…

1898 CE

#2003

Sur une substance nouvelle radio-active, contenue dans la pechblende.

The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…

1939 CE

#3213

Tabakmissbrauch und Lungencarcinom.

In the first case-control epidemiological study of the effects of tobacco Müller recorded a statistically significant correlation between cigarette smoking and lung cancer. See Alfredo Morabia, "Quality, original…

1948 CE

#2660.1

Temporary remissions in acute leukemia in children produced by folic acid antagonist 4-amethopteroylglutamic acid (aminopterin).

With L. K. Diamond, R. D. Mercer, R. F. Sylvester, and V. A. Wolff.

2003 CE

#7873

Teratology in the twentieth century: Congenital malformations in humans and how their environmental causes were established.

Book form publication with extensive bibliography and index, reprinted from Neurotoxicology and Teratology, 25 (2003) 132-282.