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- Anatomy & Pathology 6
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88 entries match Diagnostics & Imaging [E01] · Zoology & Animal Sciences [K01.900.500.750]
1966 CE
#14064
"Fertile" intestine nuclei.
Gurdon and Uehlinger replaced the cell nucleus of frog ova with frog intestinal nuclei to generate tadpoles, some of which became fertile adult male and female frogs. In 2012 the Nobel Prize in Physiology or Medicine …
1896 CE
#10608
14 Photographien mit Röntgen-strahlen aufgenommen im physikaloschen Verein zu Frankfurt A. M.
This collection of x-ray photographs published within a few months of Röntgen's discovery includes applications in archaeology and anthropology (x-rays of mummies) and forensic medicine (for the investigation of …
2014 CE
#14024
A brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruits.
Free access from FEBS Press at this link.
1962 CE
#256.12
Adult frogs derived from the nuclei of single somatic cells.
Demonstration that somatic and germinal nuclei are genetically equivalent. Using somatic cell nuclear transfer (SCNT), Gurdon (Nobel Prize 2012) transplanted cell nuclei from mature intestinal tadpole cells into enucl…
2022 CE
#14027
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.
Abstract: "The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of …
1895 CE
#8653
An atlas of the fertilization and karyokinesis of the ovum.
The first atlas of photomicrographs showing fertilization and cellular development during mitosis. The photomicrographs were taken by Leaming. Digital facsimile from the Internet Archive at this link.
2003 CE
#10244
ArtandMedicine.com.
http://www.artandmedicine.com/Index.html A highly personal but in all aspects extraordinary website/blog on the history of medical photography in the form of what Rowley calls his Cabinet Journal.
2005 CE
#8858
Biodiversity Heritage Library
BIODIVERSITY HERITAGE LIBRARY
http://www.biodiversitylibrary.org/ "The Biodiversity Heritage Library (BHL) is a consortium of natural history and botanical libraries that cooperate to digitize the legacy literature of biodiversity held in their co…
1914 CE
#13877
Book of monsters.
The first book of macro photographs (extreme close-up photography) of insects.
2011 CE
#10549
Books & babies: Communicating reproduction.
http://www.lib.cam.ac.uk/exhibitions/Babies/index.html "The London underground displays posters for fertility clinics, directed at both women and men. Picture books teach children the facts of life. We are always read…
1977 CE
#11208
Charles Darwin: An annotated bibliographical handlist
This bibliography has been extensively supplemented by the Freeman Bibliographical Database at Darwin Online edited by John van Wyhe. "The database has been supplemented by the entries from unpublished manuscript corr…
1981 CE
#14183
Computer averaging of electron micrographs of the 405 ribosomal subunit.
Frank and colleagues developed a method that allows sorting of particle images into classes based on their orientation, as well as their structural features. Specifically Frank developed mathematical tools used for im…
1973 CE
#257.5
Construction of biologically functional bacterial plasmids in vitro.
Cohen, Boyer and associates developed the first practical method for cloning genes, by the formation of recombinant plasmids which can be used to infect plasmid-free bacteria. The authors demonstrated that if DNA is f…
1984 CE
#14184
Cryo-electron microscopy of viruses.
Dubochet and colleagues introduced "Dubochet's vitrification method" to vitrify water by cooling it so rapidly that it solidified to form a glass instead of crystals. Using this method, the authors published the first…
2007 CE
#7881
Culturing life: How cells became technologies.
A history of tissue culture.
1963 CE
#12427
Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells.
McCulloch and Till discovered the blood-forming stem cell, the hematopoietic stem cell (HSC), through their pioneering work in mice. McCulloch and Till began a series of experiments in which bone marrow cells were inj…
2002 CE
#8706
Darwin Online. The complete works of Charles Darwin, edited by John van Wyhe.
http://darwin-online.org.uk/AboutUs.html Darwin's Complete Publications Books Origin of Species, Voyage of the Beagle, Descent of Man... Articles Volcanic, Darwin-Wallace paper... Published Letters Life and letters, D…
2016 CE
#9594
Data Refuge.
https://www.datarefuge.org/ "Data Refuge is a public and collaborative project designed to address concerns about federal climate and environmental data that is in danger of being lost[1]. In particular, the initiativ…
1909 CE
#12426
Der Lymphozyt als gemeinsame Stammzelle der verschiedenen Blutelemente in der embryonalen Entwicklung und im postfetalen Leben der Säugetiere.
Maximow developed and introduced a unitarian theory of hematopoiesis, a theory upon which the modern concept of blood cells' origin and differentiation is based. He introduced the term "stem cell." Translated into Eng…
1998 CE
#13977
Derivation of pluripotent stem cells from cultured human primordial germ cells.
Order of authorship in the original publication: Shamblott, Axelman,... Gearheart. Gearheart led the team that successfully developed human embryonic germ cells, pluripotent stem cells derived from primordial germ cel…
2003 CE
#14300
Design of a novel globular protein fold with atomic-level accuracy.
Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with convention…
1998 CE
#13286
Embryonic stem cell lines derived from human blastocysts.
Thomson and collaborators first isolated embryonic stem cells from human blastocysts. Order of authorship in original publication: Thomson, Itskovitz-Eldor, Shapiro et al. Available online from science.sciencemag.org …
2006 CE
#10910
Emily Dickinson's herbarium: A facsimile edition. Foreward by Leslie A. Morris. Essays, botanical catalogue and index by Richard B. Sewall, Judith Farr, and Ray Angelo.
A facsimile edition of MS Am 1118.11 in Houghton Library, Harvard University. Digital facsimile of the actual herbarium from Harvard at this link.
2009 CE
#12058
Environment & Society Portal.
http://www.environmentandsociety.org/ "The Environment & Society Portal is a gateway to open access resources about human participation in, and understandings of, the environment. It addresses the community of teacher…
1981 CE
#13285
Establishment in culture of pluripotential cells from mouse embryos.
Evans and Kauffman were the first to identify, isolate and successfully culture embryonic stem cells using mouse blastocysts. This discovery opened the doors to the creation of “murine genetic models” -- m…
1953 CE
#13946
Evidence for 2-chain helix in crystalline structure of sodium deoxyribonucleate.
Franklin and Gosling's completed Patterson synthesis of the A-form of DNA, based on work begun in 1952, represents the first independent confirmation that the Watson-Crick double-helix model was correct. "We suggest t…
1977 CE
#10964
Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin.
Order of authorship in the original paper: Itakura, Hirose, Crea..., Bolivar, Boyer. Synthesis of the gene for somatostatin (growth hormone-inhibiting hormone (GHIH). This was the first demonstration of a foreign gene…
1979 CE
#13980
Expression in Escherichia coli of chemically synthesized genes for human insulin (plasmid construction / lac operon / fused proteins / radioimmunoassay / peptide purification).
Working at Genentech, Kleid and Goeddel and colleagues were the first scientists to apply genetic engineering techniques, incorporating chemically synthesized DNA encoding human insulin into E. coli, that expressed, a…
1974 CE
#10047
Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.
Creation of the first transgenic organism: expression of Staphylococcus aureus genes in Escherichia coli. Digital facsimile from pnas.org at this link.
1974 CE
#10963
Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.
Confirmation of the success of methods outlined in No. 257.5. Abstract: "Genes carried by EcoRI endonuclease-generated fragments of Staphylococcus plasmid DNA have been covalently joined to the E. coli antibiotic-resi…
1778 CE–1793 CE
#8222
Geographische Geschichte des Menschen und der allgemein verbreiteten vierfüßigen Thiere: nebst einer hieher gehörigen Zoologischen Weltcharte. 3 vols.
Digital facsimile from the Bayerische StaatsBibliothek at this link.
2012 CE
#8065
Health and illness: Images of difference.
1953 CE
#256.4
Helical structure of crystalline deoxypentose nucleic acid.
In 1962 Wilkins shared the Nobel Prize in Physiology or Medicine with Crick and Watson "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living…
2021 CE
#14026
Highly accurate protein structure prediction with AlphaFold.
Abstract: "Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1,2,3,4, the structures of around 100,0…
1990 CE
#14237
Historical atlas of crystallography.
2020 CE
#13106
Improved protein structure prediction using potentials from deep learning.
Order of authorship in the original paper: Senior, Evans, Jumper. ABSTRACT: "Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence. This problem is…
2007 CE
#14063
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
Yamanaka (Nobel Prize 2012) and colleagues demonstrated the generation of Induced Pluripotent Stems Cells (iPS) from adult human dermal fibroblasts with the same 4 mice factors they used in GM 13287. By overexpressing…
2006 CE
#13287
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…
1978 CE
#13969
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).
Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell …
1912 CE
#6917
Interferenz-Erscheinungen bei Röntgenstrahlen. . . . Eine quantitative Prüfung der Theorie für die Interferenz-Erscheinungen bei Röntgenstrahlen
Discovery of the diffraction of X-rays in crystals. Laue’s discovery was of dual importance: it allowed the subsequent investigation of X-radiation by means of wavelength determination, and it provided the means…
2004 CE
#8068
Invention of hysteria: Charcot and the Photographic Iconography of the Salpêtrière.
See No. 4558.1
1935 CE
#2524.5
Isolation of a crystalline protein possessing the properties of tobacco-mosaic virus.
Stanley first crystallized a virus— tobacco mosaic virus. The following year Bawden, Pirie, Bernal and Fankuchen (No. 12005) showed that tobacco mosaic virus molecules are asnisometric and consist of ribonucleop…
1981 CE
#13961
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells (embryonic stem cells/inner cell masses/differentiation in vitro/embryonal carcinoma cells/growth factors) .
Martin used a different approach that avoided in vivo alteration. She reasoned that an ES cell line might be obtained by culturing cells isolated from blastocysts in a medium that had previously been conditioned by an…
1894 CE
#10595
Klinische Abbildungen: Sammlung von Darstellungen der Veränderung der äusseren Körperform bei inneren Krankheiten.
Includes 57 fine heliogravure reproductions of artistic photographs of disease, including numerous congenital deformities. Digital facsimile from Google Books at this link.
1936 CE
#12005
Liquid crystalline substances from virus infected plants.
Order of authorship in the original publication: Bawden, Pirie, Bernal, Fankuchen. The authors isolated and crystallized tobacco mosaic virus, finding for the first time that a virus contained nucleic acids, when othe…
1996 CE
#11110
Making PCR: A story of biotechnology.
2004 CE
#10508
Mapping the Victorian social body.
"The cholera epidemics that plagued London in the nineteenth century were a turning point in the science of epidemiology and public health, and the use of maps to pinpoint the source of the disease initiated an explos…
1993 CE
#8518
Medical Humanities at New York University. LITMED: Literature Arts Medicine Database.
http://medhum.med.nyu.edu/ "The Literature, Arts and Medicine Database (LitMed) is a collection of literature, fine art, visual art and performing art annotations created as a dynamic, comprehensive resource for schol…
2013 CE
#9853
Medical visions: Producing the patient through film, television, and imaging technologies.
"Kirsten Ostherr focuses on moving images produced in the United States from the early twentieth century to the present day. The types of images she considers are diverse and range from sober education films to televi…
1665 CE
#262
Micrographia, or some physiological descriptions of minute bodies made by magnifying glasses; with observations and inquiries thereupon.
Hooke, at one time research assistant to Robert Boyle, was one of the greatest inventive geniuses of all time. This was the first book devoted entirely to microscopical observations, and also the first book to pair it…