Facets

2020 CE

#11876

A bacteriophage nucleus like compartment shields DNA from CRISPR nucleases.

Order of authorship in the original publication: Mendoza, Nieweglowska, Govindarajan. The authors showed that the large phage that specifically infects a Pseudomonas bacterium segregates its DNA, which the phage CRISP…

1952 CE

#12032

A nonhereditary, host-induced variation of bacterial viruses.

Order of authorship in the original publication: Luria, Human. Luria and Human discovered the restriction modification system found in bacteria and other prokaryotic organisms. This system provides a defense against f…

1816 CE

#11799

A treatise on the medicinal leech; including its medical and natural history, with a description of its anatomical structure; also, remarks upon the diseases, preservation, and management of leeches.

Digital facsimile from the Hathi Trust at this link.

1977 CE

#11043

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

Discovery of introns. In 1993 Roberts shared the Nobel Prize in Physiology or Medicine with Phillip A. Sharp "for their discoveries of split genes." It was frequently suggested that Chow deserved a share of that prize…

1798 CE

#11796

An entire new treatise on leeches, wherein the nature, properties, and use of that most singular and valuable reptile, is most clearly set forth.

Digital facsimiel from WellcomeLibrary.org at this link.

1915 CE

#2571

An investigation on the nature of ultra-microscopic viruses.

Twort discovered discovered bacteriophages, a type of virus that attacks bacteria (the term bacteriophage was coined by Félix d’Herelle, who in 1917 independently confirmed Twort’s discovery). The d…

1786 CE

#2466

Animalcula infusoria fluviatilia et marina, quae detexit, systematice descripsit et ad vivum delineari.

Müller was the first to attempt a systematic classification of infusoria. He published several papers on the subject, the best being the above posthumous work. Muller described 8 species of the genus Vibrio (incl…

1861 CE

#2475.1

Animalcules infusoires vivant sans gaz oxygène libre et déterminant des fermentations.

The discovery of strict anaerobiosis, important for general biology since it shows that oxygen gas is not a requisite for life.

1889 CE

#10786

Antibiose et symbiose.

Villemin coined the term antibiosis and advanced the term from an evolutionary viewpoint. Though he presented the concept Villemin did not apply this concept to fight disease. (Thanks to Juan Weiss for this reference.)

1925 CE

#10197

Arrowsmith.

"This novel has been inspirational for several generations of pre-medical and medical students. There is much agonizing along the way concerning career and life decisions. While detailing Arrowsmith's pursuit of the n…

1737 CE–1738 CE

#7472

Bybel der Natuure door Jan Swammerdam, Amsteldammer...Biblia naturae; sive historia insectorum, in classes certas redacta, nec non exemplis, et anatomico variorum animalculorum examine, aeneisque tabulis illustrata. Insertis numerosis rariorum naturae observationibus. Omnia lingua Batava, auctori vernacula, conscripta. Accedit praefatio, in qu vitam auctoris descripsit Hermannus Boerhaave... Latinam versionem adscriptsit Hieronimus David Gaubius. 2 vols.

Swammerdam's extensive collection of microscopical observations on insects was written in Dutch, and edited for publication 57 years after Swammerdam's death, with an extensive life of the author, by Herman Boerhaave.…

2020 CE

#11877

Clades of huge phages from across Earth's ecosystems.

Order of authorship in the original publication: Al-Shayeb, Sachdeva, Chen.... Doudna. Open access, available from nature.com at this link. This paper was a collaboration of about 50 scientists of diverse regions and …

1863 CE

#118

Das Protoplasma der Rhizopoden und der Pflanzenzellen.

Schultze showed that protoplasm is practically identical in all living cells.

1700 CE

#2448.2

De la géneration des vers dans le corps de l’homme.

The first medical parasitology text– an exhaustive study of the parasites of man, the diseases associated with them and their treatment. Andry’s views were often ahead of his time. Unlike most of his conte…

1976 CE

#11104

Deoxyribonucleic acid polymerase from the extreme thermophile Thermus aquaticus.

The authors showed that the heat resistant bacteria Thermus aquaticus discovered by Thomas Brock contained a vital polymerase enzyme that had evolved in this bacteria to allow it to metabolize and survive in exception…

1838 CE

#111

Die Infusionsthierchen als vollkommene Organismen. 1 vol. and atlas of 64 hand-colored engraved plates.

In this monumental work in folio format Ehrenberg extended Otto Friedrich Müller’s bacteriological classification. Like Müller, he made no distinction between protozoa and bacteria, classing them both …

1669 CE

#293

Dissertatio epistolica de bombyce.

Malpighi’s work on the silkworm represents the first monograph on an invertebrate and records one of the most striking pieces of research work on his part. He dissected the silkworm under the microscope with gre…

1967 CE

#12834

Does the agent of scrapie replicate without nucleic acids?

This paper, which predated Griffith's' paper (No. 12833), demonstrated that the scrapie agent replicates without nucleic acids. Alper and colleagues irradiated scrapie infected mouse brain extracts with lethal ultravi…

1989 CE

#10926

Ebola virus infection in imported primates - Virginia, 1989.

Also published with same title in Morbidity and Mortality Weekly Report, 38 (1989) 831, 832-837. Discovery of the "Ebola Reston" strain of the Ebola virus. The strain is lethal in monkeys; it turned out to be non-path…

1835 CE

#109.1

Einige Bemerkungen und Fragen über das Keimbläschen (vesicula germinativa).

Wagner saw and described the nucleolus.

1864 CE

#5344.4

Entozoa.

Cobbold suggested (p. 36) that a mollusc was the intermediate host in bilharziasis.

1675 CE

#13272

Ephemeri Vita. Of afbeeldingh van 's menschen leven, Vertoont in de Wonderbaarlijcke en nooyt gehoorde Historie van het vliegent ende een-dagh-levent Haft of Oever-aas. Een dierken, ten aansien van sijn naam, over al in Neerlandt bekent.

In his final publication Swammerdam studied the anatomy, development and behavior of the mayfly. Translated into English as Emphemeri vita: Or the natural history and anatomy of the ephemeron, a fly that lives but fiv…

1996 CE

#12835

Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity.

The authors showed that the " 'normal prion protein' in the brains of living mice can be converted into different forms depending on the type of abnormal human prion that initiated the conversion. The result is differ…

1975 CE

#2660.27

From the molecular biology of oncogenic DNA viruses to cancer. Les Prix Nobel en 1975, pp. 172-80.

In 1975 Dulbecco shared the Nobel Prize in Physiology or Medicine with David Baltimore and Howard Martin Temin "for their discoveries concerning the interaction between tumour viruses and the genetic material of the c…

2015 CE

#11848

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.

Order of authorship in the original publication: Whitworth, Rowland, Ewen, ... Prather. Using the CRISPR Cas molecular gene-editing tool, Prather and colleagues edited the gene that codes for the CD163 protein in adul…

1952 CE

#256.1

Genetic exchange in Salmonella.

Description of a new mechanism (“transduction”) for the transfer of genetic characters from one bacterial strain to another.

1949 CE

#2526.1

Genetic recombinations leading to production of active bacteriophage from ultraviolet inactivated bacteriophage particles.

In 1969 Luria shared the Nobel Prize in Physiology or Medicine in with Delbrück (No. 2578.5) and A. D. Hershey (No. 256) "for their discoveries concerning the replication mechanism and the genetic structure of vi…

2007 CE

#11338

Genome sequence of Aedes aegypti, a major arbovirus vector.

Order of authorship in the original publication: Nene, Wortman, Lawson.... Sequence of the genome of the mosquito that transmits Zika, Yellow fever, Dengue, Chikungunya, etc. (Thanks to Juan Weiss for this reference a…

1825 CE

#11800

Histoire naturelle et médicale des sangsues, contenant la description anatomique des organes de la sangsue officinale, avec des considérations physiologiques sur ces organes; des notions très-étendues sur la conservation domestique de ce ver, sa reproduction, ses maladies, son application, etc.

Digital facsimile from Biodiversity Heritage Library at this link.

1648 CE

#2263.1

Historia naturalis Brasiliae.

Piso's study of the natural history of Brazil was also a pioneer work on tropical medicine, and also the largest work from the standpoint of format published by the Elzeviers. The folio includes De medicina brasiliens…

1962 CE

#12033

Host specificity of DNA produced by escherichia coli. II. Control over acceptance of DNA from infecting phage lambda.

Order of authorship in the original publication: Dussoix, Arber. The authors discovered that restriction of DNA from infecting bacteriophage was due to the attack and breakdown of the modified bacteriophage's DNA by s…

1979 CE

#10888

Human babesiosis on Nantucket Island, USA: Description of the vector, Ixodes dammini, N. Sp. (Acarina: Ixodidae)

Order of authorship in the original paper was Spielman, Clifford, Piesman. The authors identified and described the insect vector of Babesiosis. This was a new species; the same species causes Lyme disease. (Thanks to…

1952 CE

#256

Independent functions of viral protein and nucleic acid in growth of bacteriophage.

DNA shown to be the carrier of genetic information in virus reproduction. In 1969 Hershey shared the Nobel Prize in Physiology or Medicine with S. E. Luria and M. Delbrück for "for their discoveries concerning th…

1892 CE–1982 CE

#355

Index-catalogue of medical and veterinary zoology.

An index to the world's literature on parasites and parasitisms of man, of domestic animals, and of wild animals whose parasites may be transmitted to man and domestic animals. It also contains references to fur-beari…

1946 CE

#2578.5

Induced mutations in bacterial viruses.

Genetic recombination in bacteriophages. In 1969 Delbrück shared the Nobel Prize with A. D. Hershey and S. E. Luria "for their discoveries concerning the replication mechanism and the genetic structure of viruses."

1956 CE

#2578.17

Infectivity of ribonucleic acid from tobacco mosaic virus.

Proof that nucleic acid produces infectivity. See also Z. Naturf., 1956, 11b, 138-42.

1978 CE

#13969

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).

Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell …

2015 CE

#13186

Insects, hygiene and history.

1935 CE

#2524.5

Isolation of a crystalline protein possessing the properties of tobacco-mosaic virus.

Stanley first crystallized a virus— tobacco mosaic virus. The following year Bawden, Pirie, Bernal and Fankuchen (No. 12005) showed that tobacco mosaic virus molecules are asnisometric and consist of ribonucleop…

2020 CE

#12302

Isolation of an archeon at the prokaryote eukaryote interface.

(Order of authorship in the original publication: Imachi, Nobu, Nakahara...Takai.) The authors report that after 12 years of research they have cultured a microorganism that may be the transitional species between pro…

1644 CE

#259.1

l’Occhio della mosca In his: Opusculi…

The first microscopical section in biology is discussed and illustrated in Odierna’s study of the fly’s eye, which is also the first description of the faceted eye of an arthropod.

2013 CE

#8683

Leech.

Published in the "Animal" series. Seemingly a definitive work on the natural history and medical application of leeches.

1936 CE

#12005

Liquid crystalline substances from virus infected plants.

Order of authorship in the original publication: Bawden, Pirie, Bernal, Fankuchen. The authors isolated and crystallized tobacco mosaic virus, finding for the first time that a virus contained nucleic acids, when othe…

1834 CE

#13415

Mémoire comparatif sur l'histoire naturelle de l'insecte de la gale.

Raspail first described and illustrated the Sarcoptes scabei, diffrentiating it from the horse's sarcopt and the cheese moth that Galès and Patrix, followed by Alibert, had confused with the scabies parasite. R…

1858 CE

#10278

Mémoire sur les vers intestinaux.

Beneden's treatise on the development, transformation, and life-histories of parasitic worms won the Grand prix des sciences physiques of the Institut de France. It was published in the "International Scientific Serie…

1839 CE

#113

Mikroskopische Untersuchungen über die Uebereinstimmung in der Struktur und dem Wachsthum der Thiere und Pflanzen.

Mainly devoted to the investigation of the elementary structure of animal tissues, Schwann’s Untersuchungen had an important bearing on the development of the doctrine of the cell structure of animal tissue. In …

1981 CE

#9175

Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.

The poliovirus genome. Digital facsimile from PNAS through PubMedCentral at this link.

1829 CE–1832 CE

#109

Observations on the organs and mode of fecundation in Orchideae and Asclepiadeae.

Discovery, in 1831, of the cell nucleus. First issued as a separate pamphlet: Observations on the Organs and Mode of Fecundation in orchideae and asclepiadeae ... [with:] Additional remarks ... London, [privately prin…

1922 CE–1939 CE

#83

Œuvres de Pasteur, réunies par Pasteur Vallery-Radot. 7 vols.

One of the founders of bacteriology, Pasteur's work on fermentation, the doctrine of spontaneous generation (which he exploded), virus diseases and preventive vaccinations, was fundamental. Digital facsimile of the co…

1964 CE

#13944

On the colinearity of gene structure and protein structure.

Yanofsky and colleagues established that gene sequences and protein sequences are colinear in bacteria. Order of authorship in the original publication: Yanofsky, Carlton, ... Henning. In genetics, coliniarity is a pr…