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Historical Bibliography Updated: March 6, 2020

A bacteriophage nucleus like compartment shields DNA from CRISPR nucleases.

Publication Details

Nature, 577, 244-248. 2020 CE.

Order of authorship in the original publication: Mendoza, Nieweglowska, Govindarajan. The authors showed that the large phage that specifically infects a Pseudomonas bacterium segregates its DNA, which the phage CRISPR would attack and destroy, by building a proteinaceous compartment or wall around its DNA. This protein barrier makes its DNA inaccessible to the CRISPR nuclease attack and destruction. This could be called the operation of natural selection at the molecular level.

(Thanks to Juan Weiss for this reference and its interpretation.)

Catalog MetadataReference Information
Entry Number#11876
Permanent Linkhttps://staging.historyofmedicine.com/entry/14080
External URLa-bacteriophage-nucleus-like-compartment-shields-dna-from-crispr-nucleases