Facets

1930 CE

#5539

Die Ätiologie der Psittakosis.

Discovery of the causal agent of psittacosis, Chlamydia psittaci. Simultaneously A. C. Coles (Lancet, 1930, 1, 1011-12) and R. D. Lillie (Publ. Hlth. Rep., Wash., 1930, 45, 773-78) made the same discovery, and the ele…

1907 CE

#7395

Die Bakteriologie in der Augenheilkunde.

Translated into English by Angus McNab as The bacteriology of the eye (London: Ballière, Tyndall & Cox, 1908, and New York: William Wood & Co, 1908).

1911 CE

#5172

Die bakteriologische Blutuntersuchung beim Milzbrand des Menschen.

Salvarsan first used in the treatment of anthrax.

1886 CE

#1017

Die Darmbakterien des Säuglings und ihre Beziehungen zur Physiologie der Verdauung.

Includes the first account of Bact. coli infection. The organism was later renamed Escherichia coli (E.coli).

1906 CE

#2562

Die experimentelle Bakteriologie und die Infektionskrankheiten.

English translation, 2 vols., London, Allen & Unwin, 1934.

1910 CE

#2403

Die experimentelle Chemotherapie der Spirillosen (Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie).

After many experiments on the action of synthetic drugs upon spirochetal diseases, Ehrlich and Hata in 1909 discovered Arsphenamine (Salvarsan, "the arsenic that saves", also known as “606”), an effective …

1923 CE

#12594

Die Extrapyramidalen Erkrankungen: Mit Besonderer Berücksichtigung der pathologischen Anatomie und Histologie und der Pathophysiologie der Bewegungsstörungen.

Pages 218-245 represent Jakob's full clinical-pathologic description of the fifth patient that he first described in this work.The symptoms of this patient and the histopathopathologic illustrations correspond fully w…

1826 CE

#5481.1

Die Geschichte der Hundswuth und der Wasserscheu und deren Behandlung.

A full account of rabies, summarizing current knowledge, with a bibliography of about 300 items.

1861 CE–1862 CE

#4640

Die Gürtelkrankheit.

Herpes zoster first ascribed to a lesion of the spinal ganglia.

1848 CE

#7314

Die Hautkrankheiten durch anatomische Untersuchungen erläutert.

The first textbook of dermatopathology. "Simon dated the preface of his book April 1st, 1848 and wrote (p. vi and vii) that much has been achieved by meticulous clinical description of diseases of the skin but now att…

1894 CE

#4000

Die Histopathologie der Hautkrankheiten.

This monumental work is a landmark in dermatological history. Sir Norman Walker translated it into English in 1896. Unna, short in stature but a giant among dermatologists, initiated the study of the skin by means of …

1861 CE

#5028

Die Hydrotherapie des Typhus.

Brand’s cold bath treatment of typhoid fever consisted of total immersion in water at 65°F. and the pouring of cold water over the neck and shoulders. The cold bath treatment of fevers was instituted by Curr…

1855 CE

#5341

Die in und an dem Körper des lebenden Menschen vorkommenden Parasiten. Ein Lehr- und Handbuch der Diagnose und Behandlung der thierischen und pflanzlichen Parasiten des Menschen. Zum Gebrauche für Studirende der Medicin und der Naturwissenschaften, für Lehrer der Zoologie, Botanik, Physiologie, pathologischen Anatomie und für praktische Ärzte. 2 vols.

English translation of 2nd ed. by Edwin Ray Lankester as On animal and vegetable parasites of the human body: A manual of their natural history, diagnosis, and treatment. 2 vols. London: Sydenham Society, 1857. Digita…

1838 CE

#111

Die Infusionsthierchen als vollkommene Organismen. 1 vol. and atlas of 64 hand-colored engraved plates.

In this monumental work in folio format Ehrenberg extended Otto Friedrich Müller’s bacteriological classification. Like Müller, he made no distinction between protozoa and bacteria, classing them both …

1851 CE–1856 CE

#5865

Die Krankheiten des Auges. 3 vols.

Arlt described granular conjunctivitis (“Arlt’s trachoma”) and an operation for transplantation of the ciliary bulbs in the treatment of distichiasis.

1862 CE–1876 CE

#2453

Die menschlichen Parasiten und die von ihnen herrührenden Krankheiten. 2 vols.

Includes the first complete and accurate account of the life history and morphology of Taenia echinococcus. Leuckart proved the relationship between hydatid cysts and minute tape-worms in dogs. English translation, Ed…

1885 CE

#2503

Die Methoden der Bakterienforschung.

Hueppe, a colleague of Koch, wrote an admirable manual on bacteriological methods, a subject to which he gave several original contributions. English translation, New York, 1886.

1886 CE

#3175

Die Mikrococcen der Pneumonie.

Fraenkel showed definitely that the organism found by Pasteur (No. 3172) and Sternberg (No. 3173) was a cause of pneumonia.

1885 CE

#3294

Die Natur und die Behandlung der Ozaena.

Loewenberg described a bacillus found in the secretions of ozena (see No. 3307). He made the first attempt at the treatment of this condition.

1880 CE

#5030

Die Organismen in den Organen bei Typhus abdominalis.

Salmonella typhi, causal organism of typhoid, was discovered by Eberth. Some European writers refer to the disease as “Eberth’s disease”.

1883 CE

#2454

Die thierischen Parasiten des Menschen.

1871 CE

#2535

Die Ursache der infectiösen Wundkrankheiten.

Klebs, Professor of Pathology at Berne, Würzburg, Prague, Zurich, and Chicago, preceded Koch in investigations of the pathology of traumatic infection. He found bacteria in gunshot wounds, granulation tissue, etc…

1908 CE

#12385

Die von Pirquet'sche Hautreaktion und die intravenöse Tuberkulinbehandlung.

First publication on the The Mantoux test or Mendel–Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a tool for s…

2016 CE

#10925

Discovery and description of Ebola Zaire virus in 1976 and relevance to the West African epidemic during 2013-2016.

A first hand account of events as they occurred in Yambuku in 1976, including the causes and reasons for the spread of Ebola within the Yambuku Mission hospital, the probable index event/patient (not identified), and …

2026 CE

#14354

Discovery of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis

"Abstract: Background: The Bacille Calmette–Guérin (BCG) vaccine against tuberculosis is the most widespread vaccine in the world. Discovered by French investigators Albert Calmette and Camille Gué…

1949 CE

#5546

Disease resembling nonparalytic poliomyelitis associated with a virus pathogenic for infant mice.

Isolation of the Coxsackie virus from patients with poliomyelitis. With E. W. Shaw.

1669 CE

#293

Dissertatio epistolica de bombyce.

Malpighi’s work on the silkworm represents the first monograph on an invertebrate and records one of the most striking pieces of research work on his part. He dissected the silkworm under the microscope with gre…

2020 CE

#13479

Distinct viral reservoirs in individuals with spontaneous control of HIV-1.

The authors describe a mechanism for the observed natural viral "immunity" of individuals with spontaneous control of HIV-1. A very few exceptional people have the molecular ability to steer the incoming/infecting cel…

1880 CE

#5346.2

Distoma ringeri.

Manson made a fundamental contribution to knowledge on paragonimiasis with his description of its etiology and of the parasite. He named it Distoma ringeri after Dr. Ringer, who recovered it from the lung at necropsy;…

1967 CE

#12834

Does the agent of scrapie replicate without nucleic acids?

This paper, which predated Griffith's' paper (No. 12833), demonstrated that the scrapie agent replicates without nucleic acids. Alper and colleagues irradiated scrapie infected mouse brain extracts with lethal ultravi…

1889 CE

#5486

Drüsenfieber.

“Pfeiffer’s disease”. He is sometimes credited with the original description of infectious mononucleosis, ascribed to Filatov. Pfeiffer’s paper is a most comprehensive discussion of the clinica…

1898 CE

#2514

Du séro-diagnostic dans les affections gastro-intestinales d’origine alimentaire.

Discovery of Salmonella aertrycke, independently of Durham.

2013 CE

#11459

Duodenal infusion of donor feces for recurrent Clostridium difficile.

Order of authorship in the original publication: Nood, Vrieze, Nieuwdorp....This research provided convincing evidence that fecal donation (faecal microbiota transplantation) is more effective therapy for virulent C. …

1918 CE

#3542

Dysentery bacilli: the differentiation of the true dysentery bacilli from allied species.

Shigella alkalescens described.

1978 CE

#10924

Ebola virus haemorrhagic fever. Edited by Stefan R. Pattyn.

Among the essays in this book two are of special note: 1. Piot, P., Sureau, P., Breman, J.G., Clinical aspects of Ebola virus infection in Yambuku area, Zaire, 1976 (pp. 157-166). This is the first clinical descriptio…

1989 CE

#10926

Ebola virus infection in imported primates - Virginia, 1989.

Also published with same title in Morbidity and Mortality Weekly Report, 38 (1989) 831, 832-837. Discovery of the "Ebola Reston" strain of the Ebola virus. The strain is lethal in monkeys; it turned out to be non-path…

2021 CE

#13507

Efficacy and safety of the mRNA-1273 SARSCov-2 vaccine.

mRNA-1273 is synonymous with the Moderna mRNA Covid-19 vaccine. The Moderna mRNA vaccine was produced from theoretical design to finished product and distribution in less than one year. This was the first published pa…

1998 CE

#10900

Ehrlichia chaffeensis in Missouri ticks.

Order of authorship in the original paper: Roland, Everett, Cyr. Using PCR, the authors demonstrated that the tick Amblyoma americanum (the Lone Star Tick) was the insect vector of Ehrlichia chaffeensis. Digital facsi…

1999 CE

#10903

Ehrlichia ewingii, a newly recognized agent of human Ehrlichiosis.

Order of authorship in the original publication: Buller, Arens, Hmiel. The authors confirmed that the agent of human granulocytic ehrlichiosis (HGE), is Ehrlichia ewingii, a pathogen carried by dogs and known in that …

1852 CE

#5339

Ein Beitrag zur Helminthographia humana aus brieflichen Mittheilungen des Dr. Bilharz in Cairo, nebst Bemerkungen von C. T. v. Siebold.

Discovery, in 1851, of Schistosoma haematobium, the parasite of bilharziasis. Bilharz was Professor of Zoology at Cairo. English translation in Rev. infect. Dis., 1984, 4, 727-32, and in Kean (No. 2268.1).

1862 CE

#5344.1

Ein Beitrag zur Pathologie der Trichinenkrankheit beim Menschen.

First confirmed diagnosis of trichinosis in a living person.

1887 CE

#2505.1

Eine kleine Modification des Koch’schen Plattenverfahrens.

Petri dish. A similar dish was described by Cornil and Babès (see No. 2501) and by Nicati and Rietsch, Arch. Physiol. norm. path., 1885, 6, 72. Petri was an assistant of Koch.

1896 CE

#2549

Eine neue Methode zur raschen Erkennung des Choleravibrio und des Typhusbacillus.

The discovery of bacterial agglutination. Gruber and Durham discovered the agglutinating action of the serum of typhoid patients upon the typhoid bacillus. First briefly reported by Durham: On a special action of seru…

1917 CE

#5095

Eine neuer Typus aus der Gruppe der Ruhrbazillen als Erreger einer grösseren Epidemie.

Schmitz’s bacillus – Bact. ambiguum (Shigella schmitzii),a cause of dysentery.

1835 CE

#109.1

Einige Bemerkungen und Fragen über das Keimbläschen (vesicula germinativa).

Wagner saw and described the nucleolus.

1943 CE

#14005

Electron microscope studies of bacterial viruses.

This work demonstrated the absorption of the phages on the host cell, and the lysis of the host cell and the liberation of a hundred or so daughter paritcles from each cell. It also showed that the particles multiply …

2011 CE

#10904

Emergence of a new pathogenic Ehrlichia species, Wisconsin and Minnesota, 2009.

Order of authorship in the original publication: Pritt, Sloan, Johnson. Discovery of a new species of Ehrlichia, initially denoted as "Wisconsin and Minnesota, 2009," that was not related to E. chaffeensiis or E. ewin…

2005 CE

#12113

Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters.

Order of authorship in the original publication: Wolfe, Heniene, Carr ...Birx.... "As of 2016, 301 terrestrial mammals were threatened with extinction due to hunting for bushmeat including primates, even-toed ungulate…

2014 CE

#10928

Emergence of Zaire Ebola virus disease in Guinea.

Order of authorship in the original paper: Baize, Pannetier, Oestereich. The authors used PCR, viral sequencing, and phylogenetic analysis to track down the index case, a two-year-old child in Meliandou village, Gu&ea…

1930 CE

#5540

En Bornholmsk epidemi-myositis epidemica.

First full description of epidemic myositis, “Bornholm disease”. See also Sylvest’s monograph on the subject, London, 1934.