Facets

1978 CE

#7456

A gene complex controlling segmentation in Drosophila.

Discovery of the Drosophila Bithorax complex and elucidation of its function. Lewis founded the field of developmental genetics and laid the groundwork for current understanding of the universal, evolutionarily conser…

1977 CE

#6926

A new method for sequencing DNA.

The Gilbert-Maxam method for sequencing DNA. This paper is available from PNAS at this link. In 1980 Gilbert shared the 1980 Nobel Prize in Chemistry with Frederick Sanger and Paul Berg. Berg received half of the priz…

1970 CE

#6889

A restriction endonuclease from Hemophilus influenzae. II. Base sequence of the recognition site.

Discovery of the first type II restriction enzyme (HindII). Smith shared the 1978 Nobel Prize in Physiology or Medicine with Werner Arber and Daniel Nathans "for the discovery of restriction enzymes and their applicat…

1927 CE

#251.1

Artificial transmutation of the gene.

Muller showed that radiation causes mutations that are passed on from one generation to the next. This was the first suggestion that inherited traits might be altered or controlled, and it created a sensation: “…

1976 CE

#2660.28

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Discovery of the first “oncogene. In 1989 Varmus and Bishop shared the Nobel Prize for in Physiology or Medicine "for their discovery of the cellular origin of retroviral oncogenes."

1977 CE

#6883

DNA sequencing with chain-terminating inhibitors.

Sanger and colleagues developed methods for rapid sequencing of long sections of DNA molecules. Sanger’s method, and that developed by Gilbert and Maxam, made it possible to read the nucleotide sequence for enti…

1985 CE

#10785

Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis.... In 1993 the Nobel Prize in Chemist…

1946 CE

#255.4

Gene recombination in Escherichia coli.

Discovery of sexual processes in the reproduction of bacteria. In 1958 Lederberg shared the Nobel Prize in Physiology or Medicine with Tatum and Beadle (No. 254.3) "for his discoveries concerning genetic recombination…

1941 CE

#254.3

Genetic control of biochemical reactions in Neurospora.

Beadle and Tatum proposed the "one gene, one enzyme" hypothesis in 1941. This was a restatement of ideas originally proposed by Archibald Garrod (No. 244.1) in 1908. 1958 Beadle and Tatum shared the Nobel Prize in Phy…

1974 CE

#13934

Genetic control of the cell division cycle in yeast.

In 2001 Hartwell shared the Nobel Prize in Physiology or Medicine with Tim Hunt and Sir Paul M. Nurse "for their discoveries of key regulators of the cell cycle." See also No. 13933. In this paper the authors demonstr…

1949 CE

#2526.1

Genetic recombinations leading to production of active bacteriophage from ultraviolet inactivated bacteriophage particles.

In 1969 Luria shared the Nobel Prize in Physiology or Medicine in with Delbrück (No. 2578.5) and A. D. Hershey (No. 256) "for their discoveries concerning the replication mechanism and the genetic structure of vi…

1958 CE

#2578.30

Histocompatibility genes of the mouse.

Snell made fundamental contributions to transplantation genetics. At his suggestion genes governing transplantation were called histocompatibility genes and Gorer’s Antigen II became Histocompatibility-2 (H-2). …

2016 CE

#8539

History within: The science, culture, and politics of bones, organisms, and molecules.

1819 CE

#11240

Lectures on physiology, zoology and the natural history of man.

This work set forth Lawrence's then radical and remarkably advanced ideas concerning evolution and heredity. Arguing that theology and metaphysics had no place in science, Lawrence relied instead on empirical evidence…

1980 CE

#7455

Mutations affecting segment number and polarity in Drosophilia.

In 1995 Nüsslein-Volhard and Wieschaus shared the Nobel Prize in Physiology or Medicine with Edward B. Lewis "for their discoveries concerning the genetic control of early embryonic development."

1868 CE

#224

Natürliche Schöpfungsgeschichte. Gemeinverständlich wissenschaftliche Vorträge über die Entwickelungslehre im Allgemeinen und diejenige von Darwin, Goethe und Lamarck im Besonderen, über die Anwendung derselben auf den Ursprung des Menschen . . .

Haeckel constructed the first of the now commonplace ancestral trees, depicting the evolution of life from the simplest organisms through 21 stages of development to modern man – the 22nd and final stage. Within…

1876 CE–1877 CE

#2391

On irregular and defective tooth development.

“Moon’s molars”, the first molars in congenital syphilitics.

1988 CE

#10228

Racial hygiene: Medicine under the Nazis.

1968 CE

#13935

Reconstruction of three-dimensional structures from electron micrographs.

Klug and deRosier invented methods for two-dimensional and three-dimensional digital image processing of electron microscope images. The latter method provided the theory behind the development of computed tomography …

1858 CE

#2386

Report on the effects of infantile syphilis in marring the development of the teeth.

Hutchinson of St. Bartholomew’s Hospital, is memorable for his original description of the notched incisors (“Hutchinson’s teeth”) in congenital syphilis. His name is also associated with &ldqu…

1910 CE

#245.2

Sex-limited inheritance in Drosophila.

Morgan demonstrated sex-limited inheritance. In 1933 Morgan was awarded the Nobel Prize in Physology or Medicine "for discoveries elucidating the role that the chromosome plays in heredity." See also Nos. 245.3, 246, …

1987 CE

#13931

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

In 2007 Capecchi shared the 2007 Nobel Prize in Physiology or Medicine with Martin J. Evans and Oliver Smithies "for their discoveries of principles for introducing specific gene modifications in mice by the use of em…

1971 CE

#6890

Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae.

Nathans showed that the restriction enzyme discovered by Hamilton Smith cleaved SV40 DNA into 11 specific pieces. Nathans and his student Kathleen Danna wrote: "The availability of pieces of SV40 DNA from specific sit…

1999 CE

#10053

The black stork: Eugenics and the death of "defective" babies in American medicine and motion pictures since 1915.

2014 CE

#7289

The complete genome sequence of a Neanderthal from the Altai Mountains.

First complete sequence of a Neanderthal genome. With more than 20 co-authors. In 2022 Pääbo was awarded the Nobel Prize in Physiology or Medicine "for his discoveries concerning the genomes of extinct homin…

1974 CE

#9941

The genetics of CAENORHABDITIS ELEGANS.

In 2002 Brenner shared the Nobel Prize in Physiology or Medicine in Physiology or Medicine with H. Robert Horvitz and John Sulston "for their discoveries concerning genetic regulation of organ development and programm…

2018 CE

#14099

The genome of the offspring of a Neanderthal mother and a Denisovan father.

Paleogenomic study of a single bone fragment from a female hominin found in the Denisova Cave in the Altai mountains of Russia provided "direct evidence for genetic mixture between Neanderthals and Denisovans on at le…

1994 CE

#8538

The history and geography of human genes.

The first full-scale attempt to reconstruct where human populations originated and the paths by which they spread throughout the world, using genetic data integrated with data from geography, ecology, archaeology, phy…

2020 CE

#14098

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.

Expanding on previous findings by a genome wide association study of severe COVID-19, specifically with respiratory failure which had found that a gene cluster residing on chromosome 3 had a significant association wi…

1950 CE

#12063

The origin and behavior of mutable loci in maize.

"In the summer of 1944 at Cold Spring Harbor Laboratory, McClintock systematic studies on the mechanisms of the mosaic color patterns of maize seed and the unstable inheritance of this mosaicism.[44] She identified tw…

2010 CE

#7844

The Oxford handbook of the history of eugenics. Edited by Alison Bashford and Philippa Levine.

1792 CE

#6358

Von Menschen ohne Haare und Zähne.

Hereditary ectodermal dysplasia first described. Digital facsimile from Google Books at this link.