Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis....

In 1993 the Nobel Prize in Chemistry 1993 was awarded "for contributions to the developments of methods within DNA-based chemistry." Mullis received half "for his invention of the polymerase chain reaction (PCR) method," and the other half was awarded to Michael Smith "for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies."

See also No. 7213.

(Thanks to Juan Weiss for this reference.)