Facets

1876 CE

#8911

The effects of cross and self fertilisation in the vegetable kingdom.

Darwin's report on over 12 years of experimentation with cross and self-fertilization on 57 species. In these experiments Darwin discovered and demonstrated the concept of hybrid vigor or heterosis.

1923 CE

#7407

The elephant man and other reminiscences.

The story of Treves's patient, Joseph Carey Merrick (1862-1890), incorrected identified by Treves in these reminiscences as "John Merrick." The story was retold in The elephant man, Bernard Pomerance's 1977 play about…

1990 CE

#7966

The emergence of bacterial genetics.

2007 CE

#7954

The emergence of genetic rationality: Space, time & information in American biological science, 1870-1920.

1942 CE

#13316

The epigenotype.

Waddington coined the term epigenetics: "For the purpose of a study of inheritance, the relation between phenotypes and genotypes [...] is, from a wider biological point of view, of crucial importance, since it is the…

2005 CE

#11594

The eugenics movement: An encyclopedia.

1966 CE

#258.5

The gene: A critical history.

2016 CE

#9617

The gene: An intimate history.

1937 CE

#2576.5

The genetic and antigenic basis of tumour transplantation.

Gorer made the initial discoveries which formed the basis of transplantation genetics. He studied mouse blood groups and described an antigen in erythrocytes (antigen II). His studies established the laws of transplan…

1964 CE

#257.1

The genetical evolution of social behaviour I, II.

Hamilton’s mathematical theory of kin selection as an explanation for the evolution of social behavior (including supposedly altruistic behavior), is the foundation of sociobiology.

1930 CE

#253

The genetical theory of natural selection.

The first coherent general algebraic analysis of Mendelian population behavior. The work contains Fisher’s rigorous development of his “fundamental theorem of natural selection”–”the rate…

1974 CE

#9941

The genetics of CAENORHABDITIS ELEGANS.

In 2002 Brenner shared the Nobel Prize in Physiology or Medicine in Physiology or Medicine with H. Robert Horvitz and John Sulston "for their discoveries concerning genetic regulation of organ development and programm…

1924 CE

#2573.1

The genetics of tissue transplantation in mammals.

Little established that the homograft reaction was due to genetic differences between donor and recipient.

2006 CE

#9722

The genetics revolution: History, fears and future of a life-altering science.

2005 CE

#11339

The genome of the African trypanosome Trypanosoma brucei.

Genome of the parasite that causes Sleeping Sickness. (Thanks to Juan Weiss for this reference and its interpretation.)

2018 CE

#14099

The genome of the offspring of a Neanderthal mother and a Denisovan father.

Paleogenomic study of a single bone fragment from a female hominin found in the Denisova Cave in the Altai mountains of Russia provided "direct evidence for genetic mixture between Neanderthals and Denisovans on at le…

2002 CE

#11337

The genome sequence of the malaria mosquito Anopheles gambiae.

Order of authorship in the original publication: Holt, Subramanian, Halpern.... Sequence of the genome of Anopheles gambiae, the mosquito that carries the malaria parasite, Plasmodium falciparum. (Thanks to Juan Weiss…

2003 CE

#10863

The genome sequence of the SARS-associated coronavirus.

Dated May 30, 2003 and published immediately after No. 10862 in the same issue of Science, this reported the work of Marco Marra and his team in Canada. Order of authorship in the published paper was Marra, Jones, Ast…

1934 CE

#3093

The haemostatic possibilities of snake-venom.

Snake venom used in the treatment of hemophilia.

2013 CE

#14101

The haplotype-resolved genome and epigenome of the aneuploidy HeLa cancer cell line.

Adey and colleagues sequenced the haplotype-resolved whole genome of the HeLa cancer cell line. This showed a highly rearranged region at chromosome 8q24.21, where an integration locus of the HPV (human papillomavirus…

1994 CE

#8538

The history and geography of human genes.

The first full-scale attempt to reconstruct where human populations originated and the paths by which they spread throughout the world, using genetic data integrated with data from geography, ecology, archaeology, phy…

2020 CE

#13776

The human gene editing debate.

"Provides a history of the debate about gene editing, a summary of the ethics, and a proposal for moving forward. Re-conceptualizes the historical discussion about gene editing in the context of today's widespread use…

1931 CE

#253.2

The inborn factors in disease.

Garrod argued that chemical individuality could result in individuals having a predisposition to certain diseases. This view has become particularly significant in light of the establishment of recombinant DNA methods…

1949 CE

#3154.2

The inheritance of sickle cell anemia.

Genetic evidence that sickle-cell disease is inherited in a simple Mendelian manner.

1912 CE

#11535

The Kallikak family: A study in the heredity of feeble-mindedness.

When this book was published Goddard was Director of the Research Laboratory of the Training School at Vineland, New Jersey, for Feeble-minded Girls and Boys. Though this work drew wide attention to the problems of pe…

1913 CE

#245.4

The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association.

Proof that the genes are arranged in a linear sequence along the chromosome. Sturtevant determined the relative positions of six genetic factors on a fly’s chromosome by creating a process called gene mapping. T…

2020 CE

#14098

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.

Expanding on previous findings by a genome wide association study of severe COVID-19, specifically with respiratory failure which had found that a gene cluster residing on chromosome 3 had a significant association wi…

1986 CE

#8606

The man behind the syndrome.

Portraits and biographies, emphasizing genetic syndromes. Followed by the authors' The person behind the syndrome (1997).

1915 CE

#246

The mechanism of Mendelian heredity.

Summarizes the major early findings of Morgan’s Drosophila research group, which based its research on the rapidly reproducing small vinegar fly, Drosophila melanogaster, often called the fruit fly. This epoch-m…

1793 CE

#2281

The morbid anatomy of some of the most important parts of the human body.

Baillie was a nephew and pupil of William Hunter. The above is the first systematic textbook of morbid anatomy, treating the subject for the first time as an independent science. See also Nos. 2736, 3167.1. Baillie wa…

1977 CE

#6884

The nucleotide sequence of bacteriophage phi-X174.

Sanger and colleagues sequenced the first whole DNA genome—that of bacteriophage phi-X174 (5375 bases)

1895 CE

#4365

The operative treatment of congenital dislocation of the hip-joint.

Lorenz suggested a bloodless method for closed reduction of congenital dislocation of the hip-joint – the “Hoffa–Lorenz” method.

1950 CE

#12063

The origin and behavior of mutable loci in maize.

"In the summer of 1944 at Cold Spring Harbor Laboratory, McClintock systematic studies on the mechanisms of the mosaic color patterns of maize seed and the unstable inheritance of this mosaicism.[44] She identified tw…

1967 CE

#258.6

The origins of genetics: A Mendel source book.

1971 CE

#258.7

The origins of theoretical population genetics.

2010 CE

#7844

The Oxford handbook of the history of eugenics. Edited by Alison Bashford and Philippa Levine.

1972 CE

#7433

The palmar fascia.

"There have been many descriptions of the palmar fascia by anatomists and in papers dealing with the surgical treatment of Dupuytren's contracture, but what seems to be lacking is an overall view of the problem, based…

1886 CE

#4750

The peroneal type of progressive muscular atrophy. Thesis for the degree of M.D. in the University of Cambridge.

Tooth described peroneal muscular atrophym a hereditary motor and sensory neuropathy of the peripheral nervous system, independently of, and in the same year as, Charcot and Marie. Known as Charcot-Marie-Tooth (CMT) d…

1919 CE

#13915

The physical basis of heredity.

In this book Morgan first used the word gene. Previously he had used the term "Mendelian unit" or "factor." On the basis of genetic analysis Morgan presented a number of characteristics of genes: 1. A gene could have …

2013 CE

#13532

The PKU paradox: A short history of a genetic disease.

1935 CE

#3095

The prothrombin in hemophilia and in obstructive jaundice.

Quick’s method for determination of prothrombin clotting time. See also Amer. J. med. Sci.,1935, 190,501-11.

1948 CE

#3107.2

The reduction of methaemoglobin in red blood cells and studies on the cause of idiopathic methaemoglobinaemia.

Cause of hereditary methemoglobinemia elucidated.

1941 CE

#3100

The rôle of iso-immunization in the pathogenesis of erythroblastosis fetalis.

Erythroblastosis fetalis due to rhesus incompatibility (Rh disease) between mother and child. With L. Burnham, E. M. Katzin, and P. Vogel.

2001 CE

#6892

The sequence of the human genome.

Initial draft sequence of the human genome by Venter and the staff at Celera Genomics. The full text is available from Science at this link.

1980 CE

#14108

The striking resemblance of high-resolution G-banded chromosomes of man and chimpanzee.

Chimpanzees are the closest primates genetically to humans. In this paper the authors demonstrated the genetic changes that differentiated humans from chimpanzees. By comparing human and chimpanzee chromosomes the aut…

1958 CE

#13560

The suppressor-mutator system of control of gene action in maize.

In this paper McClintock described a novel mobile genetic element that she called Suppressor-Mutator (Spm), and its complex regulation. She discovered that Spm could switch back and forth between an “inactive&rd…

1945 CE

#3043

The surgical treatment of malformations of the heart in which there is pulmonary stenosis or pulmonary atresia.

The “Blalock-Taussig operation” for the relief of congenital defects of the pulmonary artery, Tetralogy of Fallot ("blue baby syndrome"). "The first surgical repair was carried out in 1944 at Johns Hopkins…

1926 CE

#251

The theory of the gene.

1868 CE

#224.1

The variation of animals and plants under domestication. 2 vols.

Darwin carried out numerous investigations with pigeons and various plants. He recognized continuous and discontinuous variation; he concluded that crossing tends to keep populations uniform.

1784 CE

#2734.3

Three cases of mal-conformation of the heart.

Three cases of congenital heart disease recorded. Two plates are opposite pp. 417-18 of the journal.