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8 entries match Physiology & Embryology [G07 / G02.149] · Professions & Education [M01 / N02] · Physics, Math & Biomechanics [K01.900.400]
1966 CE
#14064
"Fertile" intestine nuclei.
Gurdon and Uehlinger replaced the cell nucleus of frog ova with frog intestinal nuclei to generate tadpoles, some of which became fertile adult male and female frogs. In 2012 the Nobel Prize in Physiology or Medicine …
1973 CE
#2700.4
Computerized transverse axial scanning (tomography).
Hounsfield invented computer-assisted tomography (CAT), or computed tomography (CT). In 1979 Hounsfield shared the Nobel Prize in Physiology or Medicine with Allen M. Cormack "for the development of computer assisted …
1680 CE–1681 CE
#3669.3
De motu animalium. 2 pts.
Borelli originated the neurogenic theory of the heart’s action and first suggested that the circulation resembled a simple hydraulic system. He was the first to insist that the heart beat was a simple muscular c…
1981 CE
#13285
Establishment in culture of pluripotential cells from mouse embryos.
Evans and Kauffman were the first to identify, isolate and successfully culture embryonic stem cells using mouse blastocysts. This discovery opened the doors to the creation of “murine genetic models” -- m…
2006 CE
#13287
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…
1963 CE
#8149
Representation of a Function by its Line Integrals, with Some Radiological Applications.
Cormack showed that changes in tissue density could be computed from x-ray data. Because of limitations in computing power no machine was constructed during the 1960s. Cormack's papers generated little interest until …
1987 CE
#13931
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
In 2007 Capecchi shared the 2007 Nobel Prize in Physiology or Medicine with Martin J. Evans and Oliver Smithies "for their discoveries of principles for introducing specific gene modifications in mice by the use of em…
1987 CE
#13940
Targeted correction of a mutant HPRT gene in mouse embryonic stem cells.
Smithies discovered, simultaneously with Mario Capecchi and Martin Evans, the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previ…