Facets

2020 CE

#11876

A bacteriophage nucleus like compartment shields DNA from CRISPR nucleases.

Order of authorship in the original publication: Mendoza, Nieweglowska, Govindarajan. The authors showed that the large phage that specifically infects a Pseudomonas bacterium segregates its DNA, which the phage CRISP…

1977 CE

#11043

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

Discovery of introns. In 1993 Roberts shared the Nobel Prize in Physiology or Medicine with Phillip A. Sharp "for their discoveries of split genes." It was frequently suggested that Chow deserved a share of that prize…

2020 CE

#11877

Clades of huge phages from across Earth's ecosystems.

Order of authorship in the original publication: Al-Shayeb, Sachdeva, Chen.... Doudna. Open access, available from nature.com at this link. This paper was a collaboration of about 50 scientists of diverse regions and …

1976 CE

#11104

Deoxyribonucleic acid polymerase from the extreme thermophile Thermus aquaticus.

The authors showed that the heat resistant bacteria Thermus aquaticus discovered by Thomas Brock contained a vital polymerase enzyme that had evolved in this bacteria to allow it to metabolize and survive in exception…

1967 CE

#12834

Does the agent of scrapie replicate without nucleic acids?

This paper, which predated Griffith's' paper (No. 12833), demonstrated that the scrapie agent replicates without nucleic acids. Alper and colleagues irradiated scrapie infected mouse brain extracts with lethal ultravi…

2015 CE

#11848

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.

Order of authorship in the original publication: Whitworth, Rowland, Ewen, ... Prather. Using the CRISPR Cas molecular gene-editing tool, Prather and colleagues edited the gene that codes for the CD163 protein in adul…

2007 CE

#11338

Genome sequence of Aedes aegypti, a major arbovirus vector.

Order of authorship in the original publication: Nene, Wortman, Lawson.... Sequence of the genome of the mosquito that transmits Zika, Yellow fever, Dengue, Chikungunya, etc. (Thanks to Juan Weiss for this reference a…

1952 CE

#256

Independent functions of viral protein and nucleic acid in growth of bacteriophage.

DNA shown to be the carrier of genetic information in virus reproduction. In 1969 Hershey shared the Nobel Prize in Physiology or Medicine with S. E. Luria and M. Delbrück for "for their discoveries concerning th…

1977 CE

#11044

Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significa…

2020 CE

#11868

The arms race between bacteria and their phage foes.

Order of authorship in the original publication: Hampton, Watson, Fineran. Summarizes, and documents with 173 references, the extensive research on the multitude of methods that bacteriophages use to disable the CRISP…