Facets

1978 CE

#567.2

A history of microtechnique: The evolution of the microtome and the development of tissue preparation.

1931 CE

#2524

A new series of graded collodion membranes suitable for general bacteriological use, especially in filterable virus studies.

In his important studies on the filtration of virus preparations, Elford showed that different viruses possessed different and characteristic sizes.

1924 CE

#5082

A skin test for susceptibility to scarlet fever.

The “Dick test” for the determination of individual susceptibility to scarlet fever.

1778 CE

#2465

Abhandlung fiber die Saamen- und Infusionsthierchen, und über die Erzeugung: nebst mikroskopischen Beobachtungen des Saamens der Thiere, und verschiedener Infusionen.

Gleichen was probably the first to attempt to stain bacteria; he used carmine and indigo.

1838 CE–1857 CE

#11117

Anatomie microscopique. Tome premier: Histologie. Atlas de cinquante-deux planches. Tome second: Histogénèse. Atlas de quarante planches. 2 vols.

This work was issued in parts over nearly 20 years. Parts concerned specific subjects and were sold separately. Digital facsimile from Google Books at this link, and at this link.

1966 CE

#11105

Antibiotic susceptibility testing by a standardized single disk method.

The disk diffusion test, or agar diffusion test, or Kirby–Bauer test (disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test, KB test), for the antibiotic sensitivity of bacter…

1877 CE

#2487

Beitrag zur Kenntnis der Anilinfärbungen und ihrer Verwendung in der mikroskopischen Technik.

Ehrlich’s first paper on the staining of specific granulation in white blood corpuscles by means of aniline dyes. His work immensely affected subsequent technical methods of staining.

1872 CE

#2173

Beiträge zur pathologischen Anatomie der Schusswunden.

Klebs filtered the discharges from gunshot wounds, found the filtrate to be non-infectious, and from that reasoned that traumatic septicemia is of bacterial origin. He was the first to filter bacteria and to experimen…

1870 CE

#268

Beschreibung eines Mikrotoms.

His was, more than any other person, responsible for the introduction of the microtome, although Ranvier and other French people had earlier employed microtomes of simpler types.

1956 CE–1960 CE

#86.4

Collected papers of Paul Ehrlich. Compiled and edited by F. Himmelweit. 3 vols.

Vol. I: Histology, biochemistry, and pathology, Vol. 2: Immunology and cancer research; Vol. 3: Chemotherapy. Most texts are in German. English translations are also published when available. The set includes new Engl…

1844 CE–1845 CE

#267.1

Cours de microscopie. 1 vol. and atlas.

Donne's and Foucault's work was the first biomedical textbook to be illustrated with images made from photomicrographs, in this case daguerreotypes of blood cells. Among its noteworthy images are the first microphotog…

1885 CE

#2503

Die Methoden der Bakterienforschung.

Hueppe, a colleague of Koch, wrote an admirable manual on bacteriological methods, a subject to which he gave several original contributions. English translation, New York, 1886.

1908 CE

#12385

Die von Pirquet'sche Hautreaktion und die intravenöse Tuberkulinbehandlung.

First publication on the The Mantoux test or Mendel–Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a tool for s…

1887 CE

#2505.1

Eine kleine Modification des Koch’schen Plattenverfahrens.

Petri dish. A similar dish was described by Cornil and Babès (see No. 2501) and by Nicati and Rietsch, Arch. Physiol. norm. path., 1885, 6, 72. Petri was an assistant of Koch.

1943 CE

#14005

Electron microscope studies of bacterial viruses.

This work demonstrated the absorption of the phages on the host cell, and the lysis of the host cell and the liberation of a hundred or so daughter paritcles from each cell. It also showed that the particles multiply …

1881 CE

#2495

Essays on the floating-matter of the air in relation to putrefaction and infection.

Tyndall interested himself in atmospheric germs and dust. His experiments on sterilization by heat led him to the discovery in 1877 of fractional sterilization (Tyndallization). His work on the subject is included in …

2014 CE

#12155

Global Health Events web archive.

Global Health Events web archive "Collected by: National Library of Medicine "Archived since: Oct, 2014 "Description: "A selective collection of over 12,000 web resources archived by the National Library of Medicine b…

1653 CE

#260

Historiarum et observationum medico-physicarum centuria prima (-secunda).

The first work to apply microscopy to medicine. Borel described 200 observations and applications; he probably saw the blood corpuscles and Sarcoptes scabiei.

2020 CE

#12117

Infectious mononucleosis diagnosed by Downey cells: Sometimes the old ways are better.

The Downey cell method for the diagnosis of infectious mononucleosis remains effective and cost-effective nearly 100 years after it was discovered: "An 18-year-old woman visited her physician because she had a fever, …

1978 CE

#13969

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).

Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell …

1935 CE

#2524.5

Isolation of a crystalline protein possessing the properties of tobacco-mosaic virus.

Stanley first crystallized a virus— tobacco mosaic virus. The following year Bawden, Pirie, Bernal and Fankuchen (No. 12005) showed that tobacco mosaic virus molecules are asnisometric and consist of ribonucleop…

1936 CE

#12005

Liquid crystalline substances from virus infected plants.

Order of authorship in the original publication: Bawden, Pirie, Bernal, Fankuchen. The authors isolated and crystallized tobacco mosaic virus, finding for the first time that a virus contained nucleic acids, when othe…

1859 CE

#2473

Nouveaux faits pour server à l’histoire de la levure lactique.

This and the preceding entry mark Pasteur’s commencement of the study of fermentation. This paper described Pasteur’s method of cultivating micro-organisms in a medium free of organic nitrogen to produce f…

1686 CE–1718 CE

#265

Ontledingen en ontdekkingen.... 6 vols.

Leeuwenhoek, one of the first and also one of the greatest of the microbiologists, communicated many of his discoveries to the Royal Society in London. This set is a collection in Dutch of many contributions that van …

1887 CE

#10596

Photography of bacteria. Illustrated with eight-six photographs reproduced in autotype.

The first book entirely devoted to the photography of bacteria. Digital facsimile from Google Books at this link.

1892 CE

#2545.1

Practical results of bacteriological researches.

Sternberg demonstrated that the serum of an animal recovered from vaccinia possesses the property of neutralizing the activity of the causative virus. His test was readily adaptable for use in various host-systems.

1932 CE

#5351.1

Precipitin and skin tests as aids in diagnosing trichinosis.

Intradermal test for trichinosis.

1896 CE

#2550

Recherches de la réaction agglutinante dans le sang et le sérum desséchés des typhiques et dans la sérosité des vesicatoires.

Developing the work of Gruber and Durham, Widal noted that a patient’s serum could be tested with bacteria of known type and his disease identified by this means. They demonstrated specific agglutinins in the bl…

1967 CE

#5509.4

Rubella-virus hemagglutination-inhibition test.

With five co-authors.

1884 CE

#2498.1

Sur un filtre donnant de l’eau physiologiquement pure.

Chamberland filter, an unglazed porcelain bar with pores smaller than bacteria, enabled the earliest distinction between viruses and bacteria and led in 1898 to the re-introduction of the Latin word "virus" with the i…

1904 CE

#4004

Surla radiothérapie des teignes.

Sabouraud’s method of radiological treatment of ringworm.

1941 CE

#2577

The agglutination of red cells by allantoic fluid of chick embryos infected with influenza virus.

Discovery of virus hemagglutination. Between 1941 and 1942 Hirst developed the hemagglutination assay for quantifying the relative concentration of viruses, bacteria or antibodies.

1939 CE–2015 CE

#12964

The collected letters of Antoni Van Leeuwenhoek / Alle de Brieven van Antoni Van Leeuwenhoek. Edited, illustrated & annotated by a committee of Dutch scientists. 17 vols. through 2015.

1905 CE–1906 CE

#5440

The histology of the skin lesions in varicella.

Tyzzer was first to recognize inclusion bodies in varicella.

1942 CE

#14004

The identification and characterization of bacteriophages with the electron microscope.

First identification, observation under the electron microscope, and reproduction of photomicrographs of bacteriophages taken through the electron microscope. Digital facsimile, but with poor reproductions of the two …

1934 CE

#12387

The isolation and properties of the purified protein derivative of tuberculin

Purification of tuberculin (PPD). By the 1940s Seibert's PPD was the international standard for tuberculin tests.

1846 CE–1849 CE

#544

The microscopic anatomy of the human body, in health and disease.

First English textbook on microscopical anatomy. His description of the concentric corpuscles of the thymus (p. 9) led to the term “Hassall’s corpuscles”.

1965 CE

#14035

The nature of the Negri Body.

The first visual proof, by publication of electron micrographs at 25,000 magnification, that Negri bodies contain enormous numbers of rabies virus particles. Digital facsimile from rupress.org at this link. (Thanks to…

1919 CE

#12006

The use of blood agar for the study of streptococci.

In this monograph with numerous charts and 34 full-page plates Brown classified streptococci into α, β, A prime and γ based on the type and degree of hemolysis produced by the bacteria on a blood agar…

1871 CE

#2482

Ueber Bakterien in der Pockenhaut.

Weigert was the first to stain bacteria. He introduced many of the best staining methods in use today. Weigert discovered bacteria in hemorrhagic smallpox. In the same paper is described how carmine will color cocci.

1881 CE

#2493

Ueber das Methylenblau und seine klinisch-bakterioskopische Verwerthung.

Introduction of methylene blue in bacteriological staining.

1884 CE

#2499

Ueber die isolirte Färbung der Schizomyceten in Schnitt- und Trocken-präparaten.

Gram’s method of staining bacteria (Gram stain). While not all bacteria may be definitively classified in this way, it is almost always the first step in the preliminary identification of a bacterial organism.

1876 CE

#2486

Ueber eine Mykose bei einem neugeborenen Kinde (Bakterienfärbung mit Anilinfarben).

In this paper Weigert showed that methyl violet will reveal cocci in tissues.

1863 CE

#548.1

Ueber Eiter- und Bindegewebskörperchen.

Recklinghausen described granular cells in the frog mesentery, later named “mast cells” by Ehrlich (No. 553.1).

1891 CE

#2506.1

Ueber Wasserfiltration durch Filter aus gebrannter Infusorienerde.

Berkefeld kieselguhr filter.

1877 CE

#2488

Verfahrungen zur Untersuchung, zum Conserviren und Photographiren der Bacterien.

Koch greatly improved staining methods; he laid the foundations of the technical procedures employed in bacteriology today. In the above paper he described his method of slide preparation, making films of bacteria on …

2016 CE

#7804

Virus: An illustrated guide to 101 incredible microbes.

Includes historical data, spectacular color photomicrographs, drawings, and geographical range maps for 101 viruses

1890 CE

#2332

Weitere Mittheilungen über ein Heilmittel gegen Tuberkulose.

In 1890, Koch announced the discovery of tuberculin, a substance derived from tubercle bacilli, which he thought was capable of arresting bacterial development in-vitro and in animals. This news gave rise to tremendou…

1881 CE

#2495.1

Zur Untersuchungen von pathogenen Organismen.

Koch’s description of his methods of growing bacterial cultures in gelatine solutions, making films of bacteria on cover slips and fixing them by gentle heat, and staining slides differentially by aniline. These…