Facets

1962 CE

#256.12

Adult frogs derived from the nuclei of single somatic cells.

Demonstration that somatic and germinal nuclei are genetically equivalent. Using somatic cell nuclear transfer (SCNT), Gurdon (Nobel Prize 2012) transplanted cell nuclei from mature intestinal tadpole cells into enucl…

1982 CE

#14018

Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells.

Chilton was the first (1977) to demonstrate the presence of a fragment of Agrobacterium Ti plasmid DNA in the nuclear DNA of crown gall tissue. Her research on Agrobacterium also showed that the genes responsible for …

1928 CE

#2856.1

Beiträge zur Lehre von den angeborenen Herzfehlern.

Roesler described the most important roentgenologic sign of aortic coarctation.

1986 CE

#13990

Fluorescence detection in automated DNA sequence analysis.

Invention of the first semi-automated DNA sequencing machine by Leroy H. Hood, Lloyd M. Smith and colleagues. Abstract of the paper: "We have developed a method for the partial automation of DNA sequence analysis. Flu…

1974 CE

#10047

Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.

Creation of the first transgenic organism: expression of Staphylococcus aureus genes in Escherichia coli. Digital facsimile from pnas.org at this link.

1894 CE

#10595

Klinische Abbildungen: Sammlung von Darstellungen der Veränderung der äusseren Körperform bei inneren Krankheiten.

Includes 57 fine heliogravure reproductions of artistic photographs of disease, including numerous congenital deformities. Digital facsimile from Google Books at this link.

1983 CE

#13975

Metallothionein - human GH fusion genes stimulate growth of mice.

Brinster and Palmiter created the first "transgenic" animals, transferring non-native genes into mice through genetic engineering techniques. The cover of the issue of Science magazine in which this paper was publishe…

1994 CE

#9718

Molecular politics: Developing American and British regulatory policy for genetic engineering, 1972-1982.

2020 CE

#13485

Novel 2019 coronavirus genome.

https://virological.org/t/novel-2019-coronavirus-genome/319 "Novel 2019 coronavirus genome "10th January 2020 "This posting is communicated by Edward C. Holmes, University of Sydney on behalf of the consortium led by …

1968 CE

#13935

Reconstruction of three-dimensional structures from electron micrographs.

Klug and deRosier invented methods for two-dimensional and three-dimensional digital image processing of electron microscope images. The latter method provided the theory behind the development of computed tomography …

1987 CE

#13931

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

In 2007 Capecchi shared the 2007 Nobel Prize in Physiology or Medicine with Martin J. Evans and Oliver Smithies "for their discoveries of principles for introducing specific gene modifications in mice by the use of em…

1877 CE

#4344.1

Spinal disease and spinal curvature, their treatment by suspension and the use of the plaster of Paris bandage.

Sayre’s monograph on his methods of treating tuberculosis of the spine and scoliosis is the first American surgical textbook to contain actual mounted photographs, some of which are remarkable for their artistic…

1999 CE

#10053

The black stork: Eugenics and the death of "defective" babies in American medicine and motion pictures since 1915.

2006 CE

#9722

The genetics revolution: History, fears and future of a life-altering science.

2020 CE

#13776

The human gene editing debate.

"Provides a history of the debate about gene editing, a summary of the ethics, and a proposal for moving forward. Re-conceptualizes the historical discussion about gene editing in the context of today's widespread use…