Facets

1982 CE

#14018

Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells.

Chilton was the first (1977) to demonstrate the presence of a fragment of Agrobacterium Ti plasmid DNA in the nuclear DNA of crown gall tissue. Her research on Agrobacterium also showed that the genes responsible for …

2011 CE

#13571

Correction of the 508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

Negulescu and colleagues published a "proof of concept" experiment showing that the novel molecule called VX-809 could correct in vitro the very common and critical 508del-CFTR mutation identified by Collins. (See GM …

1938 CE

#13827

Cystic fibrosis of the pancreas and its relation to celiac disease: A clinical and pathological study.

Andersen was the first to describe the characteristic cystic fibrosis of the pancreas, and to correlate it with the lung and intestinal disease prominent in CF. She also was the first to hypotheize that cystic fibrosi…

1900 CE

#239.01

Das Spaltungsgesetz der Bastarde.

De Vries and Correns independently rediscovered and confirmed Mendel’s laws. This is De Vries’s most important paper on the subject. De Vries’s first published paper on the topic is “Sur la loi…

1901 CE–1903 CE

#240

Die Mutationstheorie. 2 vols.

The theory of mutation was first advanced by de Vries. English translation, 2 vols., Chicago, 1909-10.

1957 CE

#9726

Drug reactions, enzymes and biochemical genetics.

Motulsky clearly stated that inheritance might explain many individual differences in the efficacy of drugs and in the occurence of adverse drug reactions.

1925 CE

#3087.1

Familial icterus gravis of the new-born and its treatment.

Successful exchange transfusion.

1906 CE

#242.3

Further experiments on inheritance in sweet peas and stocks; preliminary account.

W. Bateson, E. R. Saunders and R. C. Punnett noted the phenomena of linkage of genes.

1958 CE

#12971

Influence of light on the hyperbilirubinaemia of infants.

In 1956 Sister Jean Ward of the Premature Unit of the Rochford General Hospital in Essex, England noted the benefit of phototherapy when she took infants outside because she assumed that fresh air had healing benefits…

1902 CE

#241

Mendel’s principles of heredity: A defence.

The first book on Mendelism in English, and the first English textbook of genetics. It contains a reprint of the first English translation of Mendel’s “Versuch über Pflanzen-Hybriden” from the J…

1959 CE

#9727

Moderne problem der humangenetik.

In this paper Vogel coined the term pharmacogenetics, as the study of the role of genetics in drug response.

1878 CE

#4075.1

On the treatment of psoriasis by an ointment of chrysophanic acid.

Introduction of chrysarobin in dermatology.

1948 CE

#3107.1

Replacement transfusion as a treatment for erythroblastosis fetalis.

Exchange transfusion.

1876 CE

#8911

The effects of cross and self fertilisation in the vegetable kingdom.

Darwin's report on over 12 years of experimentation with cross and self-fertilization on 57 species. In these experiments Darwin discovered and demonstrated the concept of hybrid vigor or heterosis.

1934 CE

#3093

The haemostatic possibilities of snake-venom.

Snake venom used in the treatment of hemophilia.

1868 CE

#224.1

The variation of animals and plants under domestication. 2 vols.

Darwin carried out numerous investigations with pigeons and various plants. He recognized continuous and discontinuous variation; he concluded that crossing tends to keep populations uniform.

1903 CE

#242

Ueber Erblichkeit in Populationen und in reinen Linien.

More support for the Mendelian law of inheritance was provided by Johannsen, a Danish botanist, who showed that in certain self-fertilizing plants a pure line of descendants can be maintained indefinitely, in which ca…

1866 CE

#222

Versuche über Pflanzen-Hybriden.

Discovery of the Mendelian ratios, the most significant single achievement in the history of genetics. The story of how Mendel published his paper in this relatively obscure journal only to have his discovery ignored …