Facets

2012 CE

#11844

A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.

Order of authorship in the original publication: Jinek, Chylinski, Fonfar, Hauer, Doudna, Charpentier. Doudna, Charpentier and colleagues showed for the first time that the CRISPR evolutionary immune tool of bacteria …

1977 CE

#11043

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

Discovery of introns. In 1993 Roberts shared the Nobel Prize in Physiology or Medicine with Phillip A. Sharp "for their discoveries of split genes." It was frequently suggested that Chow deserved a share of that prize…

1985 CE

#8388

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.

Blackburn and Grieder discovered telomerase in the ciliate Tetrahymena. In 2009 Blackburn and Grieder shared the Nobel Prize in Physiology or Medicine with Jack W. Szostak "for the discovery of how chromosomes are pro…

1952 CE

#256

Independent functions of viral protein and nucleic acid in growth of bacteriophage.

DNA shown to be the carrier of genetic information in virus reproduction. In 1969 Hershey shared the Nobel Prize in Physiology or Medicine with S. E. Luria and M. Delbrück for "for their discoveries concerning th…

1961 CE

#12015

No time for prejudice: A story of the integration of negroes in nursing in the United States.

Primarily a history of the National Association of Colored Graduate Nurses [NACGN], which existed for the express purpose of "promoting unity within the nursing profession and furthering the cause of democracy." Integ…

2018 CE

#11382

Rhetoric, medicine, and the woman writer, 1600–1700.

"How did physicians come to dominate the medical profession? Lyn Bennett challenges the seemingly self-evident belief that scientific competence accounts for physicians' dominance. Instead, she argues that the whole e…

1977 CE

#11044

Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significa…

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1955 CE

#6928

The crystal structure of the hexacarboxylic acid derived from B12 and the molecular structure of the vitamin.

The final structure of vitamin B12. With J. Pickworth, J.H. Robertson, K.N. Trueblood, R.J. Prosen, J. G. White. In 1964 Hodgkin was awarded the Nobel Prize in Chemistry "for her determinations by X-ray techniques of …

1981 CE

#14224

The crystallization of ribsomal proteins from the 50 S subunit of the Escherichia coli and Bacillus stearothermophilus ribosome.

The authors crystallized fragments of the 50S subunit of a thermophile bacterium’s ribosome to 3 angstroms resolution. Order of authorship in the original publication: Appelt, Dyck, et al., Yonath. Digital facsi…

1986 CE

#8088

The path we tread: Blacks in nursing, 1854-1984.