AXELROD, Julius (1912 – 2004)
1912 – 2004
3 entries in the GMN corpus.
Image source intramural.nimh.nih.gov · Public domain
1948 CE
#7802
The estimation of acetanilide and its metabolic products, aniline, N-acetyl p-aminophenol and p-aminophenol (free and total conjugated) in biological fluids and tissues.
Brodie and Axelrod confirmed that paracetamol, also known as acetaminophen, was the major metabolite of acetanilide in human blood, and established that it was efficacious an analgesic. Unlike its precursors, paraceta…
1958 CE
#1931.6
Enzymatic O-methylation of epinephrine and other catechols.
The authors discovered the enzyme "COMT" or cathecol-O-methyltransferase, and determined that it was crucial in the methylation and inactivation of adrenergic and other catecholamine type neurotransmitters. (Thanks to…
1961 CE
#14281
Fate of tritiated noradrenaline at the sympathetic nerve endings.
Using electron microscopy and tritiated norepinephrine, the authors discovered the area in the nerve endings in which the catecholamines were concentrated, and also observed enhanced radioactive catecholamine release …