DOISY, Edward Adelbert (1883 – 1986)

1920 CE

#744

Rapid colorimetric methods for the determination of phosphorus in urine and blood.

1923 CE

#1183

An ovarian hormone.

Isolation of the active principle of the ovarian hormone (oestrin). More detailed account in J. biol. Chem., 1924, 61, 711-23.

1924 CE

#1184

The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone.

Test for recognition of the estrus hormone.

1927 CE

#1185

The menstrual cycle of the monkey, Macacus rhesus. Observations on normal animals, the effects of removal of the ovaries and the effects of injection of ovarian and placental extracts into the spayed animals.

This paper marks the beginning of modern knowledge of the menstrual cycle. Allen showed that uterine bleeding occurs as a withdrawal effect when estrogen ceases to act on the endometrium.

1930 CE

#1193

The preparation of the crystalline ovarian hormone from the urine of pregnant women.

First isolation of a pure crystalline hormone (estrone). Preliminary communication in Amer. J. Physiol., 1929, 90, 329-30.

1939 CE

#1081

The isolation of vitamin K1.

Order of authorship in the original publication: Binkley, MacCorquodale, Thayer, Doisy. In 1943 Doisy received half of the Nobel Prize in Physiology or Medicine "for his discovery of the chemical nature of vitamin K."…

1940 CE

#1082

The constitution of vitamin K2.

Structural formula of vitamin K2.