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Garrison-Morton-Norman History of Medicine
DALE, Sir Henry Hallett (1875 – 1968)

DALE, Sir Henry Hallett (1875 – 1968)

1875 – 1968

12 entries in the GMN corpus.

Image source Michieli · [1] · CC BY 4.0

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1906 CE

#1895

An active alkaloid from ergot.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)
BARGER, George (1878 – 1939)
BARGER, George (1878 – 1939) & et al.

Isolation of ergotoxine. With F. H. Carr.

1909 CE

#1159

The action of extracts of the pituitary body.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)

Oxytocic action of posterior pituitary injection.

1910 CE

#1898

Chemical structure and sympathomimetic action of amines.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)
BARGER, George (1878 – 1939)
BARGER, George (1878 – 1939)

Discovery of histamine in an ergot extract.

1910 CE

#1899

The physiological action of β-iminoazolylethylamine.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)
LAIDLAW, Sir Patrick Playfair (1881 – 1940)
LAIDLAW, Sir Patrick Playfair (1881 – 1940)

Study of the effect of histamine.

1911 CE

#1901.1

β-iminazolylethylamine a depressor constituent of intestinal mucosa.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)
BARGER, George (1878 – 1939)
BARGER, George (1878 – 1939)

Isolation of histamine from animal tissues.

1913 CE

#2600.5

The anaphylactic reaction of plain muscle in the guinea-pig.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)

See No. 2600.2. Dale concluded that histamine induced hypersensitivity reactions.

1918 CE–1919 CE

#792

The vasodilator action of histamine and of some other substances.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)
RICHARDS, Alfred Newton (1876 – 1966)
RICHARDS, Alfred Newton (1876 – 1966)

Dale and Richards studied the effect of histamine on the control of the circulation and showed its peripheral action to be located in the capillaries and smaller arterioles.

1919 CE

#5630

Histamine shock.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)
LAIDLAW, Sir Patrick Playfair (1881 – 1940)
LAIDLAW, Sir Patrick Playfair (1881 – 1940)

Experimental shock produced by histamine and shown to be similar to traumatic and surgical shock.

1928 CE

#856.1

A double perfusion-pump.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968) SCHUSTER, Edgar Hermann Joseph (1899 – 1969)

Mechanical heart.

1929 CE

#1345

The presence of histamine and acetylcholine in the spleen of the ox and the horse.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968) DUDLEY, Harold Ward (1887 – 1935)

Isolation of acetylcholine from ox and horse spleen.

1936 CE

#1353

Reactions of the normal mammalian muscle to acetylcholine and to eserine.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)
FELDBERG, Wilhelm Siegmund (1900 – 1993)
FELDBERG, Wilhelm Siegmund (1900 – 1993)
BROWN, Sir George Lindor (1903 – 1971)
BROWN, Sir George Lindor (1903 – 1971)

c. 1914 CE

#1340

The action of certain esters and ethers of choline, and their relation to muscarine.

DALE, Sir Henry Hallett (1875 – 1968)
DALE, Sir Henry Hallett (1875 – 1968)

Demonstration of the inhibitory action of acetylcholine on the heart. In 1936 Dale shared the Nobel Prize in Physiology or Medicine with Otto Loewi (No. 1343) "for their studies in the chemical mediation of nervous im…