Facets

1926 CE

#1915

On the chemotherapy of neurosyphilis and trypanosomiasis.

Study of the effect of twelve different substances in neurosyphilis and trypanosomiasis.

1570 CE

#5372

Opera medicinalia.

Opera medicinalia was the first medical book printed in the Western Hemisphere, and its botanical images were the first illustrations of plants printed in the Western Hemisphere. Of the original edition only two copie…

1676 CE

#61

Opera. 6 vols.

Besides giving early accounts of scarlatina and rubella, Sennert added to the knowledge of scurvy, dysentery and alcoholism. He was an able clinician and also a believer in witchcraft. His Opera was first published in…

1968 CE

#14303

Oral maintenance therapy for cholera in adults.

Abstract: "An oral solution containing glucose, sodium chloride, sodium bicarbonate, and potassium chloride or citrate was used as maintenance therapy for acute cholera. In comparison with control patients who receive…

1971 CE

#14304

Oral or nasogastric maintenance therapy in pediatric cholera patients.

1944 CE

#4689.1

Penicillin in the treatment of meningitis.

1943 CE

#2418

Penicillin treatment of early syphilis. A preliminary report.

Mahoney and colleagues introduced penicillin in treatment of syphilis. This was the report of the first four cases of patients with early stages of the disease. Digital facsimile of the version published in the the Am…

1948 CE

#5261.2

Pentaquine (Sn-13,276), a therapeutic agent effective in reducing the relapse rate in vivax malaria.

Clinical trials of pentaquine. With B. Craige, R. Jones, C. M. Whorton, T. N. Pullman, and L. Eichelberger.

1944 CE

#2442

Preliminary report on diasone in the treatment of leprosy.

Muir found diasone (a sulphone) valuable in the treatment of leprosy.

1950 CE

#5262.3

Primaquine, S.N. 13,272, a new curative agent in vivax malaria: a preliminary report.

Introduction of primaquine.

1820 CE

#5233

Recherches chimique sur les quinquinas.

Isolation of quinine.

1835 CE

#1698

Recherches sur les effets de la saignée dans quelques maladies inflammatoires, et sur l’action de l’émétique et des vésicatoires dans la pneumonie.

Louis refuted Broussais’s system of medicine, his “médicine physiologique.” Louis was instrumental in establishing medicine as an exact science by the introduction of the numerical or statisti…

2021 CE

#13524

REGN-COV-2, a neutralizing antibody cocktail, in outpatients with Covid-19.

The authors showed that the Regeneron antibody cocktail has a low incidence of side effects and a profound and rapid effect on viral load, with most reduction occurring within 48 hours, even in patents with the highes…

2020 CE

#13523

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.

The authors, working at Regeneron, showed that a cocktail of two potent neutralizing monoclonal antibodes reduced virus load in the airways and diminshed viral induced pathological sequelae when given both as a prophy…

1905 CE

#5279

Report on trypanosomes, trypanosomiasis, and sleeping sickness, being an experimental investigation into their pathology and treatment.

Thomas and Breinl discovered that arsanilic acid, was more potent in the treatment of laboratory trypanosomiasis than arsenic in inorganic form. As a crystalline powder it was introduced medically as Atoxyl. Thomas an…

1567 CE

#9053

Secretos de chirurgia, en especial de la enfermedades de morbo-galico y lamparones, y asimismo la manera como se curan los indos las llgas y heridas, y otras pasiones en las Indias, muy útil y provechoso par España, y otros muchos secretos de chirugia hasta ahora no escritos.

Arias de Benevides travelled to the New World where he observed native remedies and reported them in this book. In the book he also described his performance in Mexico City (1561) of the first neurosurgical interventi…

1945 CE

#2350

Streptomycin in treatment of clinical tuberculosis: a preliminary report.

1928 CE

#5256.1

Studies in malaria, with special references to treatment. Part IX. Plasmoquine in the treatment of malaria.

Clinical trials of pamaquin.

1945 CE

#5260

Studies on synthetic antimalarial drugs.

F. H. S. Curd, D. G. Davey, and F. L. Rose synthesized proguanil (“paludrine”) and first tested it in avian malaria.

1945 CE

#5261

Studies on synthetic antimalarial drugs. XIII. Results of a preliminary investigation of the therapeutic action of 4888 (paludrine) on acute attacks of benign tertian malaria.

First use of proguanil in human malaria. With B. G. Maegraith, J. D. King, R. H. Townsend, T. H. Davey, and R. E. Havard.

1921 CE

#5287

Studies on the treatment of human trypanosomiasis with tryparsamide (the sodium salt of N-phenylglycineamide-p-arsonic acid).

Introduction of tryparsamide in the treatment of trypanosomiasis.

1947 CE

#5351.4

Sur la chimiothérapie de l’onchocercose. (Note préliminaire).

First effective chemotherapy (suramin) for onchocerciasis. With C. Heurard, E. Peel, and M. Wanson.

1938 CE

#1926

The action of substances allied to 4:4'-diaminodiphenylsulphone in streptococcal and other infections in mice.

G. A. H. Buttle, T. Dewing, G. E. Foster, W. H. Gray, S. Smith, and D. Stephenson discovered the potency of dapsone (DDS).

1985 CE

#11377

The association between idiopathic hemolytic uremic syndrome and infection by Verotoxin-producing Escherichia coli.

Order of authorship in the original publication: Karmali, Petric, Lim. The authors discovered that a hemolytic uremic syndrome, associated with E. coli 0157-H7 (first described in No. 11376), and which could not be cu…

1904 CE

#2437

The constituents of chaulmoogra seeds.

Hydnocarpus wightiana or Chaulmoogra is a tree in the Achariaceae family. The oil from seeds of Hydnocarpus wightiana or Chaulmoogra, a tree in the Achariaceae family, was widely used in Indian medicine and Chinese tr…

1943 CE

#2441

The promin treatment of leprosy. A progress report.

Promin (sodium glucosulphone) introduced in the treatment of leprosy. With R. C. Pogge, F. A. Johansen, J. F. Dinan, B. M. Prejean, and C. G. Eccles.

1844 CE

#10446

The theory and treatment of fevers. Revised and corrected by Ferdinando Stith.

The first medical treatise published in Missouri and the first medical treatise published west of the Mississippi River. "John Sappington provided medical services, was a financial lender, and imported and exported go…

1937 CE

#5214.1

The use of sulfanilamide in gonococcic infections. Preliminary report.

1712 CE

#5231

Therapeutice specialis ad febres quasdam pemiciosas, inopinato, ac repente lethales, una vera china china, peculiare methodo ministrata, sanabiles

Torti’s work finally established the specific nature of cinchona bark. His demonstration of its effectiveness in periodic over continuous fevers finally overthrew the doctrine of the common origin of all fevers.…

1929 CE–1931 CE

#12146

Ticks, mites and venomous animals of medical and veterinary importance. Part 1: Medical. Part 2: Public health.

Part 1 by Patton and the female entomologist Alwen Evans; part 2 by Patton alone.

1906 CE

#5280

Traitement des trypanosomiases par les “couleurs de benzidine”.

Introduction of trypan-blue in the treatment of trypanosomiasis. Second paper by Mesnil and Nicolle.

1694 CE

#8930

Trattado unico da constituiçam pestilencial de Pernambuco, offerecido a ElRey N.S. por ser servido ordenar por seu Governador aos Medicos da America, que assistem aonde ha este contagio, que o compusessem para se conferirem pelos Coripheos da Medicina aos dictames com que he trattada esta pestilencial febre.

The first scientific description of yellow fever in Brazil by the first European physician to treat the disease in Brazil, and perhaps in all of Latin America. It includes the description of the first autopsy of a yel…

1938 CE

#1952

Treatment of pneumonia with 2-(p-aminobenzenesulphonamido) pyridine.

Clinical proof of the value of sulphapyridine. M & B 693 (sulphapyridine) treatment of pneumonia. This followed the experimental work of L. E. H. Whitby (see No. 1951).

1920 CE

#5286

Ueber chemotherapeutische Versuche mit “205 Bayer”, einen neuen trypanoziden Mittel von besonderer Wirkung.

Introduction of “Bayer 205” (germanin, suramin, naphuride).

1918 CE–1919 CE

#4806

Ueber die Einwirkung der Malaria auf die progressive Paralyse.

In 1917 Wagner von Jauregg returned to the idea of the inoculation of paretics with malaria to induce pyrexia, first proposed by him in 1887 (Ueber die Einwirkung fieberhafter Erkrankungen auf Psychosen, Jb. Psychiat.…

1888 CE

#2506

Ueber die Fleischvergiftung in Frankenhausen. a.K. und den Erreger derselben.

Discovery of Salmonella enteritidis, a cause of food poisoning.

1891 CE

#5241.1

Ueber die Wirkung des Methylenblau bei Malaria.

Guttmann and Ehrlich demonstrated methylene blue to be lethal in vitro for the malaria parasite – the beginning of Ehrlich’s work on chemotherapy.

1946 CE

#2351

Ueber eine neue, gegen Tuberkelbazillen in vitro wirksame Verbindungsklasse.

Introduction of thiosemicarbazone in treatment of tuberculosis. With R. Behnisch, F. Mietzsch, and H. Schmidt.

1912 CE

#2405

Ueber Laboratoriumsversuche und klinische Erprobung von Heilstoffen.

Introduction of neoarsphenamine (neosalvarsan).

1943 CE

#5214.1

Use of penicillin in sulfonamide resistant gonorrheal infections.

With E. N. Cook and L. Thompson.

2015 CE

#13024

Vesalius: The China Root epistle. A new translation and critical edition, edited and translated by Daniel H. Garrison, with added illustrations from the 1543 and 1555 De humani corporis fabrica.

1932 CE

#5257

Zur Weiterentwicklung synthetisch dargestellter Malariamittel. I. Ueber die chemotherapeutische Wirkung des Atebrin.

Introduction of atebrin (mepacrine, quinacrine).