Palpitation of the heart with enlargement of the thyroid gland.

This is considered the first accurate account of exophthalmic goitre, later known as “Parry’s disease”, “Graves’s disease”, and “Basedow’s disease”. An interesting fact about the London Medical & Surgical Journal is that after the first five volumes had been published by Renshaw and edited by M. Ryan, these two separated, each continuing to publish a separate edition of the same journal. Graves’s paper appeared in the series published by Renshaw. Reprinted in Med. Classics, 1940, 5, 33-36.